Remission of adult-onset asthma is rare : a 15-year follow-up study
Background: There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. Methods: A cohort of 309 adults aged 20-60 years w...
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Umeå universitet, Avdelningen för hållbar hälsa
2020
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ftumeauniv:oai:DiVA.org:umu-179059 2024-05-19T07:46:10+00:00 Remission of adult-onset asthma is rare : a 15-year follow-up study Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179059 https://doi.org/10.1183/23120541.00620-2020 eng eng UmeÃ¥ universitet, Avdelningen för hÃ¥llbar hälsa UmeÃ¥ universitet, Avdelningen för medicin Department of Health Sciences, LuleÃ¥ University of Technology, LuleÃ¥, Sweden European Respiratory Society ERJ Open Research, 2020, 6:4, orcid:0000-0002-2358-8754 orcid:0000-0001-6622-3838 orcid:0000-0002-0553-8067 orcid:0000-0002-3292-7471 orcid:0000-0002-1630-3167 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179059 doi:10.1183/23120541.00620-2020 PMID 33263024 ISI:000603682700123 Scopus 2-s2.0-85098849252 info:eu-repo/semantics/openAccess Respiratory Medicine and Allergy Lungmedicin och allergi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1183/23120541.00620-2020 2024-04-23T23:49:17Z Background: There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. Methods: A cohort of 309 adults aged 20-60 years with asthma onset during the last 12 months verified by bronchial variability, was recruited between 1995 and 1999 from the general population in northern Sweden. The cohort was followed-up in 2003 (n=250) and between 2012 and 2014 (n=205). Structured interviews and spirometry were performed at recruitment and the follow-ups. Bronchial hyperreactivity (BHR) and skin-prick tests were performed at recruitment and blood samples were collected at the last follow-up. Remission of asthma was defined as no asthma symptoms and no use of asthma medication during the last 12 months. Results: Of eight individuals in remission in 2003, five had relapsed between 2012 and 2014 and in total, 23 (11%) were in remission, while 182 had persistent asthma. Those in remission had higher mean forced expiratory volume in 1 s % predicted at recruitment than those with persistent asthma (94.6 versus 88.3, p=0.034), fewer had severe BHR (27.3% versus 50.9%, p=0.037) and they had less body mass index increase (+1.6 versus +3.0, p=0.054). Of those with persistent asthma, 13% had uncontrolled asthma and they had higher levels of blood neutrophils than those with partly controlled or controlled asthma. Conclusion: Higher forced expiratory volume in 1 s % predicted and less-severe BHR was associated with remission of adult-onset asthma, but still, the proportion in remission in this 15-year follow-up was low. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) ERJ Open Research 6 4 00620-2020 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Respiratory Medicine and Allergy Lungmedicin och allergi |
spellingShingle |
Respiratory Medicine and Allergy Lungmedicin och allergi Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa Remission of adult-onset asthma is rare : a 15-year follow-up study |
topic_facet |
Respiratory Medicine and Allergy Lungmedicin och allergi |
description |
Background: There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. Methods: A cohort of 309 adults aged 20-60 years with asthma onset during the last 12 months verified by bronchial variability, was recruited between 1995 and 1999 from the general population in northern Sweden. The cohort was followed-up in 2003 (n=250) and between 2012 and 2014 (n=205). Structured interviews and spirometry were performed at recruitment and the follow-ups. Bronchial hyperreactivity (BHR) and skin-prick tests were performed at recruitment and blood samples were collected at the last follow-up. Remission of asthma was defined as no asthma symptoms and no use of asthma medication during the last 12 months. Results: Of eight individuals in remission in 2003, five had relapsed between 2012 and 2014 and in total, 23 (11%) were in remission, while 182 had persistent asthma. Those in remission had higher mean forced expiratory volume in 1 s % predicted at recruitment than those with persistent asthma (94.6 versus 88.3, p=0.034), fewer had severe BHR (27.3% versus 50.9%, p=0.037) and they had less body mass index increase (+1.6 versus +3.0, p=0.054). Of those with persistent asthma, 13% had uncontrolled asthma and they had higher levels of blood neutrophils than those with partly controlled or controlled asthma. Conclusion: Higher forced expiratory volume in 1 s % predicted and less-severe BHR was associated with remission of adult-onset asthma, but still, the proportion in remission in this 15-year follow-up was low. |
format |
Article in Journal/Newspaper |
author |
Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa |
author_facet |
Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa |
author_sort |
Almqvist, Linnéa |
title |
Remission of adult-onset asthma is rare : a 15-year follow-up study |
title_short |
Remission of adult-onset asthma is rare : a 15-year follow-up study |
title_full |
Remission of adult-onset asthma is rare : a 15-year follow-up study |
title_fullStr |
Remission of adult-onset asthma is rare : a 15-year follow-up study |
title_full_unstemmed |
Remission of adult-onset asthma is rare : a 15-year follow-up study |
title_sort |
remission of adult-onset asthma is rare : a 15-year follow-up study |
publisher |
Umeå universitet, Avdelningen för hållbar hälsa |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179059 https://doi.org/10.1183/23120541.00620-2020 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
ERJ Open Research, 2020, 6:4, orcid:0000-0002-2358-8754 orcid:0000-0001-6622-3838 orcid:0000-0002-0553-8067 orcid:0000-0002-3292-7471 orcid:0000-0002-1630-3167 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179059 doi:10.1183/23120541.00620-2020 PMID 33263024 ISI:000603682700123 Scopus 2-s2.0-85098849252 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1183/23120541.00620-2020 |
container_title |
ERJ Open Research |
container_volume |
6 |
container_issue |
4 |
container_start_page |
00620-2020 |
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1799486296128749568 |