A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer
Body fatness increases the risk of colorectal cancer (CRC). Insulin resistance and altered adipokines are potential mechanisms, but previous biomarker studies have been inconsistent. Intertumoral heterogeneity might provide an explanation. We investigated insulin, C-peptide, adiponectin, and leptin...
Published in: | Scientific Reports |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Umeå universitet, Onkologi
2020
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175075 https://doi.org/10.1038/s41598-020-62129-1 |
id |
ftumeauniv:oai:DiVA.org:umu-175075 |
---|---|
record_format |
openpolar |
spelling |
ftumeauniv:oai:DiVA.org:umu-175075 2023-10-09T21:54:33+02:00 A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer Myte, Robin Harlid, Sophia Sundkvist, Anneli Gylling, Björn Häggström, Jenny Zingmark, Carl Löfgren Burström, Anna Palmqvist, Richard van Guelpen, Bethany 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175075 https://doi.org/10.1038/s41598-020-62129-1 eng eng Umeå universitet, Onkologi Umeå universitet, Patologi Umeå universitet, Statistik Umeå universitet, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM) Scientific Reports, 2020, 10:1, orcid:0000-0002-2974-2003 orcid:0000-0001-8540-6891 orcid:0000-0002-4688-8952 orcid:0000-0002-9086-7403 orcid:0000-0002-9933-2843 orcid:0000-0002-9692-101X http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175075 doi:10.1038/s41598-020-62129-1 PMID 32210264 ISI:000563370200027 Scopus 2-s2.0-85082314181 info:eu-repo/semantics/openAccess Cancer and Oncology Cancer och onkologi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1038/s41598-020-62129-1 2023-09-22T13:58:25Z Body fatness increases the risk of colorectal cancer (CRC). Insulin resistance and altered adipokines are potential mechanisms, but previous biomarker studies have been inconsistent. Intertumoral heterogeneity might provide an explanation. We investigated insulin, C-peptide, adiponectin, and leptin in relation to CRC molecular subtypes using a nested case-control design (1010 cases, 1010 matched controls, median 12.3 years from baseline to CRC diagnosis) from the population-based Northern Sweden Health and Disease Study. Repeated samples were available from 518 participants. Risks of CRC and subtypes, defined by tumor BRAF and KRAS mutations and microsatellite instability (MSI) status, were estimated using conditional logistic regression and linear mixed models. Higher C-peptide and lower adiponectin were associated with increased CRC risk (odds ratios per standard deviation increase (95% CI): 1.11 (1.01, 1.23) and 0.91 (0.83, 1.00), respectively), though weakened when adjusted for body mass index. Insulin and leptin were not associated with CRC risk. Within-individual time trajectories were similar in cases and controls, and no subtype-specific relationships were identified (all Pheterogeneity > 0.1). Adiponectin was weakly inversely associated with the risk of KRAS-mutated (P = 0.08) but not BRAF-mutated or KRAS/BRAF-wildtype CRC, consistent with the one previous study. These findings contribute to an increased understanding of the complex role of body size in CRC. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Scientific Reports 10 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cancer and Oncology Cancer och onkologi |
spellingShingle |
Cancer and Oncology Cancer och onkologi Myte, Robin Harlid, Sophia Sundkvist, Anneli Gylling, Björn Häggström, Jenny Zingmark, Carl Löfgren Burström, Anna Palmqvist, Richard van Guelpen, Bethany A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
topic_facet |
Cancer and Oncology Cancer och onkologi |
description |
Body fatness increases the risk of colorectal cancer (CRC). Insulin resistance and altered adipokines are potential mechanisms, but previous biomarker studies have been inconsistent. Intertumoral heterogeneity might provide an explanation. We investigated insulin, C-peptide, adiponectin, and leptin in relation to CRC molecular subtypes using a nested case-control design (1010 cases, 1010 matched controls, median 12.3 years from baseline to CRC diagnosis) from the population-based Northern Sweden Health and Disease Study. Repeated samples were available from 518 participants. Risks of CRC and subtypes, defined by tumor BRAF and KRAS mutations and microsatellite instability (MSI) status, were estimated using conditional logistic regression and linear mixed models. Higher C-peptide and lower adiponectin were associated with increased CRC risk (odds ratios per standard deviation increase (95% CI): 1.11 (1.01, 1.23) and 0.91 (0.83, 1.00), respectively), though weakened when adjusted for body mass index. Insulin and leptin were not associated with CRC risk. Within-individual time trajectories were similar in cases and controls, and no subtype-specific relationships were identified (all Pheterogeneity > 0.1). Adiponectin was weakly inversely associated with the risk of KRAS-mutated (P = 0.08) but not BRAF-mutated or KRAS/BRAF-wildtype CRC, consistent with the one previous study. These findings contribute to an increased understanding of the complex role of body size in CRC. |
format |
Article in Journal/Newspaper |
author |
Myte, Robin Harlid, Sophia Sundkvist, Anneli Gylling, Björn Häggström, Jenny Zingmark, Carl Löfgren Burström, Anna Palmqvist, Richard van Guelpen, Bethany |
author_facet |
Myte, Robin Harlid, Sophia Sundkvist, Anneli Gylling, Björn Häggström, Jenny Zingmark, Carl Löfgren Burström, Anna Palmqvist, Richard van Guelpen, Bethany |
author_sort |
Myte, Robin |
title |
A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
title_short |
A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
title_full |
A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
title_fullStr |
A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
title_full_unstemmed |
A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
title_sort |
longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer |
publisher |
Umeå universitet, Onkologi |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175075 https://doi.org/10.1038/s41598-020-62129-1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Scientific Reports, 2020, 10:1, orcid:0000-0002-2974-2003 orcid:0000-0001-8540-6891 orcid:0000-0002-4688-8952 orcid:0000-0002-9086-7403 orcid:0000-0002-9933-2843 orcid:0000-0002-9692-101X http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175075 doi:10.1038/s41598-020-62129-1 PMID 32210264 ISI:000563370200027 Scopus 2-s2.0-85082314181 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-020-62129-1 |
container_title |
Scientific Reports |
container_volume |
10 |
container_issue |
1 |
_version_ |
1779318160992763904 |