Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study
Background: Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentr...
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Umeå universitet, Patologi
2020
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ftumeauniv:oai:DiVA.org:umu-174503 2023-10-09T21:54:31+02:00 Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study Röhnisch, Hanna E. Kyro, Cecilie Olsen, Anja Thysell, Elin Hallmans, Göran Moazzami, Ali A. 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174503 https://doi.org/10.1186/s12916-020-01655-1 eng eng Umeå universitet, Patologi Umeå universitet, Näringsforskning BMC Medicine, 2020, 18:1, orcid:0000-0001-9581-3845 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174503 doi:10.1186/s12916-020-01655-1 PMID 32698845 ISI:000555059200001 Scopus 2-s2.0-85088450932 info:eu-repo/semantics/openAccess Prostate cancer Metabolomics Nested case-control study Nuclear magnetic resonance spectroscopy Mass spectrometry Risk biomarkers Cancer and Oncology Cancer och onkologi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1186/s12916-020-01655-1 2023-09-22T13:58:23Z Background: Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age. Methods: In a case-control study nested in the Northern Sweden Health and Disease Study, pre-diagnostic concentrations of 148 plasma metabolites were determined using targeted mass spectrometry- and nuclear magnetic resonance-based metabolomics in 777 prostate cancer cases (follow-up >= 5 years) and 777 matched controls. Associations between prostate cancer risk and metabolite concentrations were investigated using conditional logistic regression conditioned on matching factors (body mass index, age and sample storage time). Corrections for multiple testing were performed using false discovery rate (20%) and Bonferroni. Metabolomics analyses generated new hypotheses, which were investigated by leveragingfood frequency questionnaires(FFQs) and oral glucose tolerance tests performed at baseline. Results: After correcting for multiple testing, two lysophosphatidylcholines (LPCs) were positively associated with risk of overall prostate cancer (all ages and in older subjects). The strongest association was for LPC C17:0 in older subjects (OR = 2.08; 95% CI 1.45-2.98;p < 0.0001, significant also after the Bonferroni correction). Observed associations with risk of overall prostate cancer in younger subjects were positive for glycine and inverse for pyruvate. For aggressive prostate cancer, there were positive associations with six glycerophospholipids (LPC C17:0, LPC C20:3, LPC C20:4, PC ae C38:3, PC ae C38:4 and PC ae C40:2), while there was an inverse association with acylcarnitine C18:2. Moreover, plasma LPC C17:0 concentrations positively correlated with estimated dietary intake of fatty acid C17:0 from the ... Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) BMC Medicine 18 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Prostate cancer Metabolomics Nested case-control study Nuclear magnetic resonance spectroscopy Mass spectrometry Risk biomarkers Cancer and Oncology Cancer och onkologi |
spellingShingle |
Prostate cancer Metabolomics Nested case-control study Nuclear magnetic resonance spectroscopy Mass spectrometry Risk biomarkers Cancer and Oncology Cancer och onkologi Röhnisch, Hanna E. Kyro, Cecilie Olsen, Anja Thysell, Elin Hallmans, Göran Moazzami, Ali A. Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study |
topic_facet |
Prostate cancer Metabolomics Nested case-control study Nuclear magnetic resonance spectroscopy Mass spectrometry Risk biomarkers Cancer and Oncology Cancer och onkologi |
description |
Background: Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age. Methods: In a case-control study nested in the Northern Sweden Health and Disease Study, pre-diagnostic concentrations of 148 plasma metabolites were determined using targeted mass spectrometry- and nuclear magnetic resonance-based metabolomics in 777 prostate cancer cases (follow-up >= 5 years) and 777 matched controls. Associations between prostate cancer risk and metabolite concentrations were investigated using conditional logistic regression conditioned on matching factors (body mass index, age and sample storage time). Corrections for multiple testing were performed using false discovery rate (20%) and Bonferroni. Metabolomics analyses generated new hypotheses, which were investigated by leveragingfood frequency questionnaires(FFQs) and oral glucose tolerance tests performed at baseline. Results: After correcting for multiple testing, two lysophosphatidylcholines (LPCs) were positively associated with risk of overall prostate cancer (all ages and in older subjects). The strongest association was for LPC C17:0 in older subjects (OR = 2.08; 95% CI 1.45-2.98;p < 0.0001, significant also after the Bonferroni correction). Observed associations with risk of overall prostate cancer in younger subjects were positive for glycine and inverse for pyruvate. For aggressive prostate cancer, there were positive associations with six glycerophospholipids (LPC C17:0, LPC C20:3, LPC C20:4, PC ae C38:3, PC ae C38:4 and PC ae C40:2), while there was an inverse association with acylcarnitine C18:2. Moreover, plasma LPC C17:0 concentrations positively correlated with estimated dietary intake of fatty acid C17:0 from the ... |
format |
Article in Journal/Newspaper |
author |
Röhnisch, Hanna E. Kyro, Cecilie Olsen, Anja Thysell, Elin Hallmans, Göran Moazzami, Ali A. |
author_facet |
Röhnisch, Hanna E. Kyro, Cecilie Olsen, Anja Thysell, Elin Hallmans, Göran Moazzami, Ali A. |
author_sort |
Röhnisch, Hanna E. |
title |
Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study |
title_short |
Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study |
title_full |
Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study |
title_fullStr |
Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study |
title_full_unstemmed |
Identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study |
title_sort |
identification of metabolites associated with prostate cancer risk : a nested case-control study with long follow-up in the northern sweden health and disease study |
publisher |
Umeå universitet, Patologi |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174503 https://doi.org/10.1186/s12916-020-01655-1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
BMC Medicine, 2020, 18:1, orcid:0000-0001-9581-3845 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174503 doi:10.1186/s12916-020-01655-1 PMID 32698845 ISI:000555059200001 Scopus 2-s2.0-85088450932 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s12916-020-01655-1 |
container_title |
BMC Medicine |
container_volume |
18 |
container_issue |
1 |
_version_ |
1779318113235369984 |