GDF-15 is associated with sudden cardiac death due to incident myocardial infarction
Aims: Preventing sudden cardiac death (SCD) due to acute myocardial infarction (MI) in previously healthy patients is challenging. Proteomic analysis may lead to an understanding of biological mechanisms and provide predictive biomarkers. Methods: In this prospective, nested case-control stu...
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Umeå universitet, Kardiologi
2020
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ftumeauniv:oai:DiVA.org:umu-173637 2024-04-28T08:32:39+00:00 GDF-15 is associated with sudden cardiac death due to incident myocardial infarction Andersson, Jonas Fall, Tove Delicano, Rachel Wennberg, Patrik Jansson, Jan-HÃ¥kan 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173637 https://doi.org/10.1016/j.resuscitation.2020.05.001 eng eng UmeÃ¥ universitet, Kardiologi UmeÃ¥ universitet, Allmänmedicin UmeÃ¥ universitet, Avdelningen för medicin Resuscitation, 0300-9572, 2020, 152, s. 165-169 orcid:0000-0002-7939-0149 orcid:0000-0002-1617-6102 orcid:0000-0003-1962-5484 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173637 doi:10.1016/j.resuscitation.2020.05.001 PMID 32422242 ISI:000542940800030 Scopus 2-s2.0-85085608649 info:eu-repo/semantics/openAccess Sudden cardiac death Myocardial infarction Proteomics GDF-15 Cardiac and Cardiovascular Systems Kardiologi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1016/j.resuscitation.2020.05.001 2024-04-09T23:38:33Z Aims: Preventing sudden cardiac death (SCD) due to acute myocardial infarction (MI) in previously healthy patients is challenging. Proteomic analysis may lead to an understanding of biological mechanisms and provide predictive biomarkers. Methods: In this prospective, nested case-control study from northern Sweden, 87 candidate cardiovascular protein biomarkers were studied in 244 individuals who later died within 24 h from an incident MI and 244 referents without MI and individually matched for age, sex and date of health examination and alive at the date of event in the index person. Association analysis was conducted using conditional logistic regression. Bonferroni correction was applied to avoid false positive findings. Results: Ten proteins were associated with future SCD due to acute MI in the non-adjusted analysis. The strongest association were found for growth differentiation factor 15 (GDF-15) with an odds ratio (OR) of 1.79 (95% confidence interval [CI] 1.41, 2.25) per standard deviation increase in protein, and urokinase-type plasminogen activator receptor with an OR of 1.66 (95% CI 1.34, 2.06). In models adjusted for lipid levels, body mass index, education, smoking, hypertension and C-reactive protein, only association with GDF-15 remained (OR 1.47 (95% 1.11, 1.95)). Conclusion: Elevated levels of GDF-15 are associated with increased risk of SCD within 24 h of incident MI. Further research may enable the use of GDF-15 together with other clinical and biological markers to guide primary preventive interventions for individuals at high risk for SCD. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Resuscitation 152 165 169 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Sudden cardiac death Myocardial infarction Proteomics GDF-15 Cardiac and Cardiovascular Systems Kardiologi |
spellingShingle |
Sudden cardiac death Myocardial infarction Proteomics GDF-15 Cardiac and Cardiovascular Systems Kardiologi Andersson, Jonas Fall, Tove Delicano, Rachel Wennberg, Patrik Jansson, Jan-HÃ¥kan GDF-15 is associated with sudden cardiac death due to incident myocardial infarction |
topic_facet |
Sudden cardiac death Myocardial infarction Proteomics GDF-15 Cardiac and Cardiovascular Systems Kardiologi |
description |
Aims: Preventing sudden cardiac death (SCD) due to acute myocardial infarction (MI) in previously healthy patients is challenging. Proteomic analysis may lead to an understanding of biological mechanisms and provide predictive biomarkers. Methods: In this prospective, nested case-control study from northern Sweden, 87 candidate cardiovascular protein biomarkers were studied in 244 individuals who later died within 24 h from an incident MI and 244 referents without MI and individually matched for age, sex and date of health examination and alive at the date of event in the index person. Association analysis was conducted using conditional logistic regression. Bonferroni correction was applied to avoid false positive findings. Results: Ten proteins were associated with future SCD due to acute MI in the non-adjusted analysis. The strongest association were found for growth differentiation factor 15 (GDF-15) with an odds ratio (OR) of 1.79 (95% confidence interval [CI] 1.41, 2.25) per standard deviation increase in protein, and urokinase-type plasminogen activator receptor with an OR of 1.66 (95% CI 1.34, 2.06). In models adjusted for lipid levels, body mass index, education, smoking, hypertension and C-reactive protein, only association with GDF-15 remained (OR 1.47 (95% 1.11, 1.95)). Conclusion: Elevated levels of GDF-15 are associated with increased risk of SCD within 24 h of incident MI. Further research may enable the use of GDF-15 together with other clinical and biological markers to guide primary preventive interventions for individuals at high risk for SCD. |
format |
Article in Journal/Newspaper |
author |
Andersson, Jonas Fall, Tove Delicano, Rachel Wennberg, Patrik Jansson, Jan-HÃ¥kan |
author_facet |
Andersson, Jonas Fall, Tove Delicano, Rachel Wennberg, Patrik Jansson, Jan-HÃ¥kan |
author_sort |
Andersson, Jonas |
title |
GDF-15 is associated with sudden cardiac death due to incident myocardial infarction |
title_short |
GDF-15 is associated with sudden cardiac death due to incident myocardial infarction |
title_full |
GDF-15 is associated with sudden cardiac death due to incident myocardial infarction |
title_fullStr |
GDF-15 is associated with sudden cardiac death due to incident myocardial infarction |
title_full_unstemmed |
GDF-15 is associated with sudden cardiac death due to incident myocardial infarction |
title_sort |
gdf-15 is associated with sudden cardiac death due to incident myocardial infarction |
publisher |
Umeå universitet, Kardiologi |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173637 https://doi.org/10.1016/j.resuscitation.2020.05.001 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Resuscitation, 0300-9572, 2020, 152, s. 165-169 orcid:0000-0002-7939-0149 orcid:0000-0002-1617-6102 orcid:0000-0003-1962-5484 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173637 doi:10.1016/j.resuscitation.2020.05.001 PMID 32422242 ISI:000542940800030 Scopus 2-s2.0-85085608649 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.resuscitation.2020.05.001 |
container_title |
Resuscitation |
container_volume |
152 |
container_start_page |
165 |
op_container_end_page |
169 |
_version_ |
1797589760914489344 |