Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden

Purpose: The aim of this study was to describe changes in the pattern of cardiovascular agents used in elderly people living in nursing homes between 2007 and 2013. Further, the aim was to analyse the use of cardiovascular drugs in relation to cognitive impairment and associated factors within the s...

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Published in:European Journal of Clinical Pharmacology
Main Authors: Svahn, Sofia, Lövheim, Hugo, Isaksson, Ulf, Sandman, Per-Olof, Gustafsson, Maria
Format: Article in Journal/Newspaper
Language:English
Published: Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap 2020
Subjects:
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169526
https://doi.org/10.1007/s00228-019-02778-y
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spelling ftumeauniv:oai:DiVA.org:umu-169526 2023-10-09T21:54:31+02:00 Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden Svahn, Sofia Lövheim, Hugo Isaksson, Ulf Sandman, Per-Olof Gustafsson, Maria 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169526 https://doi.org/10.1007/s00228-019-02778-y eng eng Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap Umeå universitet, Geriatrik Umeå universitet, Institutionen för omvårdnad Umeå universitet, Arktiskt centrum vid Umeå universitet (Arcum) Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Stockholm, Sweden European Journal of Clinical Pharmacology, 0031-6970, 2020, 76:4, s. 525-537 orcid:0000-0002-5271-4780 orcid:0000-0001-5191-4599 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169526 doi:10.1007/s00228-019-02778-y PMID 31915846 ISI:000521297200007 Scopus 2-s2.0-85077552235 info:eu-repo/semantics/openAccess Cardiovascular drugs Drug use Heart failure Major neurocognitive disorders Nursing home Geriatrics Geriatrik Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1007/s00228-019-02778-y 2023-09-22T13:53:14Z Purpose: The aim of this study was to describe changes in the pattern of cardiovascular agents used in elderly people living in nursing homes between 2007 and 2013. Further, the aim was to analyse the use of cardiovascular drugs in relation to cognitive impairment and associated factors within the same population, where prescription of loop diuretics was used as a proxy for heart failure. Methods: Two questionnaire surveys were performed including 2494 people in 2007 and 1654 people in 2013 living in nursing homes in northern Sweden. Data were collected concerning drug use, functioning in activities of daily living (ADL) and cognition, using the Multi-Dimensional Dementia Assessment Scale (MDDAS). The use of different drugs and drug classes among people at four different levels of cognitive function in 2007 and 2013 were compared. Results: The proportion of people prescribed ASA and diuretics was significantly lower at all four levels of cognitive function in 2013 compared to 2007. Among people prescribed loop diuretics, the use of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARBs) increased from 37.8 to 45.6%, β-blockers from 36.0 to 41.8% and warfarin from 4.4 to 11.4%. The use of warfarin, ACEI/ARBs, β-blockers and mineralocorticoid receptor antagonists (MRAs) were less common among individuals with more severe cognitive impairment. Conclusion: The results indicate that cardiovascular drug treatment has improved between 2007 and 2013, but there is room for further improvement, especially regarding adherence to guidelines for heart failure. Increasing cognitive impairment had an effect on treatment patterns for heart failure and atrial fibrillation. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) European Journal of Clinical Pharmacology 76 4 525 537
institution Open Polar
collection Umeå University: Publications (DiVA)
op_collection_id ftumeauniv
language English
topic Cardiovascular drugs
Drug use
Heart failure
Major neurocognitive disorders
Nursing home
Geriatrics
Geriatrik
spellingShingle Cardiovascular drugs
Drug use
Heart failure
Major neurocognitive disorders
Nursing home
Geriatrics
Geriatrik
Svahn, Sofia
Lövheim, Hugo
Isaksson, Ulf
Sandman, Per-Olof
Gustafsson, Maria
Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden
topic_facet Cardiovascular drugs
Drug use
Heart failure
Major neurocognitive disorders
Nursing home
Geriatrics
Geriatrik
description Purpose: The aim of this study was to describe changes in the pattern of cardiovascular agents used in elderly people living in nursing homes between 2007 and 2013. Further, the aim was to analyse the use of cardiovascular drugs in relation to cognitive impairment and associated factors within the same population, where prescription of loop diuretics was used as a proxy for heart failure. Methods: Two questionnaire surveys were performed including 2494 people in 2007 and 1654 people in 2013 living in nursing homes in northern Sweden. Data were collected concerning drug use, functioning in activities of daily living (ADL) and cognition, using the Multi-Dimensional Dementia Assessment Scale (MDDAS). The use of different drugs and drug classes among people at four different levels of cognitive function in 2007 and 2013 were compared. Results: The proportion of people prescribed ASA and diuretics was significantly lower at all four levels of cognitive function in 2013 compared to 2007. Among people prescribed loop diuretics, the use of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARBs) increased from 37.8 to 45.6%, β-blockers from 36.0 to 41.8% and warfarin from 4.4 to 11.4%. The use of warfarin, ACEI/ARBs, β-blockers and mineralocorticoid receptor antagonists (MRAs) were less common among individuals with more severe cognitive impairment. Conclusion: The results indicate that cardiovascular drug treatment has improved between 2007 and 2013, but there is room for further improvement, especially regarding adherence to guidelines for heart failure. Increasing cognitive impairment had an effect on treatment patterns for heart failure and atrial fibrillation.
format Article in Journal/Newspaper
author Svahn, Sofia
Lövheim, Hugo
Isaksson, Ulf
Sandman, Per-Olof
Gustafsson, Maria
author_facet Svahn, Sofia
Lövheim, Hugo
Isaksson, Ulf
Sandman, Per-Olof
Gustafsson, Maria
author_sort Svahn, Sofia
title Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden
title_short Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden
title_full Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden
title_fullStr Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden
title_full_unstemmed Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden
title_sort cardiovascular drug use among people with cognitive impairment living in nursing homes in northern sweden
publisher Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap
publishDate 2020
url http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169526
https://doi.org/10.1007/s00228-019-02778-y
genre Northern Sweden
genre_facet Northern Sweden
op_relation European Journal of Clinical Pharmacology, 0031-6970, 2020, 76:4, s. 525-537
orcid:0000-0002-5271-4780
orcid:0000-0001-5191-4599
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169526
doi:10.1007/s00228-019-02778-y
PMID 31915846
ISI:000521297200007
Scopus 2-s2.0-85077552235
op_rights info:eu-repo/semantics/openAccess
op_doi https://doi.org/10.1007/s00228-019-02778-y
container_title European Journal of Clinical Pharmacology
container_volume 76
container_issue 4
container_start_page 525
op_container_end_page 537
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