FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort
Background: The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies. Objective: The aim is to study the relationship between blood eosinophils and neutrophils and FE...
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Language: | English |
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Umeå universitet, Avdelningen för hållbar hälsa
2020
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169223 https://doi.org/10.1016/j.waojou.2020.100110 |
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ftumeauniv:oai:DiVA.org:umu-169223 2023-10-09T21:54:39+02:00 FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort Backman, Helena Lindberg, Anne Hedman, Linnea Stridsman, Caroline Jansson, Sven-Arne Sandström, Thomas Lundbäck, Bo Rönmark, Eva 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169223 https://doi.org/10.1016/j.waojou.2020.100110 eng eng Umeå universitet, Avdelningen för hållbar hälsa Umeå universitet, Avdelningen för medicin Dept of Health Sciences, Luleå University of Technology, Luleå, Sweden. , 2020, 13:3, The World Allergy Organization journal, 1939-4551, 2020, 13:3, orcid:0000-0002-0553-8067 orcid:0000-0002-3292-7471 orcid:0000-0002-1630-3167 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169223 doi:10.1016/j.waojou.2020.100110 PMID 32206161 ISI:000528838100007 Scopus 2-s2.0-85081702790 info:eu-repo/semantics/openAccess ANOVA Analysis of variance ATS American Thoracic Society Asthma BMI Body mass index Cohort ECRHS European Community Respiratory Health Survey EOS Eosinophils ERS European Respiratory Society FEV1 Forced Expiratory Volume in 1 s FEV1pp FEV1 percent of predicted FVC Forced Expiratory Volume GLI Global Lung function Initiative ICS Inhaled corticosteroids IgE Immunoglobulin E L Liters Ml Milliliters N Number NEU Neutrophils OCS Oral corticosteroids OLIN Obstructive Lung Disease in Northern Sweden OLS Ordinary Least Squares VGDF Vapors gas dust or fumes Respiratory Medicine and Allergy Lungmedicin och allergi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1016/j.waojou.2020.100110 2023-09-22T13:59:36Z Background: The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies. Objective: The aim is to study the relationship between blood eosinophils and neutrophils and FEV1 decline in a long-term follow-up of a population-based adult asthma cohort. Methods: In 2012-2014, an adult asthma cohort was invited to a follow-up including spirometry, blood sampling, and structured interviews, and n = 892 participated (55% women, mean age 59 y, 32-92 y). Blood eosinophils, neutrophils and FEV 1 decline were analyzed both as continuous variables and divided into categories with different cut-offs. Regression models adjusted for smoking, exposure to vapors, gas, dust, or fumes (VGDF), use of inhaled and oral corticosteroids, and other possible confounders were utilized to analyze the relationship between eosinophils and neutrophils at follow-up and FEV1 decline. Results: The mean follow-up time was 18 years, and the mean FEV 1 decline was 27 ml/year. The annual FEV1 decline was related to higher levels of both blood eosinophils and neutrophils at follow-up, but only the association with eosinophils remained when adjusted for confounders. Further, the association between FEV1 decline and eosinophils was stronger among those using ICS. With EOS <0.3 × 109/L as reference, a more rapid decline in FEV1 was independently related to EOS ≥0.4 × 109/L in adjusted analyses. Conclusions and clinical relevance: Besides emphasizing the importance of smoking cessation and reduction of other harmful exposures, our real-world results indicate that there is an independent relationship between blood eosinophils and FEV1 decline among adults with asthma. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) World Allergy Organization Journal 13 3 100110 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
ANOVA Analysis of variance ATS American Thoracic Society Asthma BMI Body mass index Cohort ECRHS European Community Respiratory Health Survey EOS Eosinophils ERS European Respiratory Society FEV1 Forced Expiratory Volume in 1 s FEV1pp FEV1 percent of predicted FVC Forced Expiratory Volume GLI Global Lung function Initiative ICS Inhaled corticosteroids IgE Immunoglobulin E L Liters Ml Milliliters N Number NEU Neutrophils OCS Oral corticosteroids OLIN Obstructive Lung Disease in Northern Sweden OLS Ordinary Least Squares VGDF Vapors gas dust or fumes Respiratory Medicine and Allergy Lungmedicin och allergi |
spellingShingle |
ANOVA Analysis of variance ATS American Thoracic Society Asthma BMI Body mass index Cohort ECRHS European Community Respiratory Health Survey EOS Eosinophils ERS European Respiratory Society FEV1 Forced Expiratory Volume in 1 s FEV1pp FEV1 percent of predicted FVC Forced Expiratory Volume GLI Global Lung function Initiative ICS Inhaled corticosteroids IgE Immunoglobulin E L Liters Ml Milliliters N Number NEU Neutrophils OCS Oral corticosteroids OLIN Obstructive Lung Disease in Northern Sweden OLS Ordinary Least Squares VGDF Vapors gas dust or fumes Respiratory Medicine and Allergy Lungmedicin och allergi Backman, Helena Lindberg, Anne Hedman, Linnea Stridsman, Caroline Jansson, Sven-Arne Sandström, Thomas Lundbäck, Bo Rönmark, Eva FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
topic_facet |
ANOVA Analysis of variance ATS American Thoracic Society Asthma BMI Body mass index Cohort ECRHS European Community Respiratory Health Survey EOS Eosinophils ERS European Respiratory Society FEV1 Forced Expiratory Volume in 1 s FEV1pp FEV1 percent of predicted FVC Forced Expiratory Volume GLI Global Lung function Initiative ICS Inhaled corticosteroids IgE Immunoglobulin E L Liters Ml Milliliters N Number NEU Neutrophils OCS Oral corticosteroids OLIN Obstructive Lung Disease in Northern Sweden OLS Ordinary Least Squares VGDF Vapors gas dust or fumes Respiratory Medicine and Allergy Lungmedicin och allergi |
description |
Background: The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies. Objective: The aim is to study the relationship between blood eosinophils and neutrophils and FEV1 decline in a long-term follow-up of a population-based adult asthma cohort. Methods: In 2012-2014, an adult asthma cohort was invited to a follow-up including spirometry, blood sampling, and structured interviews, and n = 892 participated (55% women, mean age 59 y, 32-92 y). Blood eosinophils, neutrophils and FEV 1 decline were analyzed both as continuous variables and divided into categories with different cut-offs. Regression models adjusted for smoking, exposure to vapors, gas, dust, or fumes (VGDF), use of inhaled and oral corticosteroids, and other possible confounders were utilized to analyze the relationship between eosinophils and neutrophils at follow-up and FEV1 decline. Results: The mean follow-up time was 18 years, and the mean FEV 1 decline was 27 ml/year. The annual FEV1 decline was related to higher levels of both blood eosinophils and neutrophils at follow-up, but only the association with eosinophils remained when adjusted for confounders. Further, the association between FEV1 decline and eosinophils was stronger among those using ICS. With EOS <0.3 × 109/L as reference, a more rapid decline in FEV1 was independently related to EOS ≥0.4 × 109/L in adjusted analyses. Conclusions and clinical relevance: Besides emphasizing the importance of smoking cessation and reduction of other harmful exposures, our real-world results indicate that there is an independent relationship between blood eosinophils and FEV1 decline among adults with asthma. |
format |
Article in Journal/Newspaper |
author |
Backman, Helena Lindberg, Anne Hedman, Linnea Stridsman, Caroline Jansson, Sven-Arne Sandström, Thomas Lundbäck, Bo Rönmark, Eva |
author_facet |
Backman, Helena Lindberg, Anne Hedman, Linnea Stridsman, Caroline Jansson, Sven-Arne Sandström, Thomas Lundbäck, Bo Rönmark, Eva |
author_sort |
Backman, Helena |
title |
FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
title_short |
FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
title_full |
FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
title_fullStr |
FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
title_full_unstemmed |
FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
title_sort |
fev1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort |
publisher |
Umeå universitet, Avdelningen för hållbar hälsa |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169223 https://doi.org/10.1016/j.waojou.2020.100110 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
, 2020, 13:3, The World Allergy Organization journal, 1939-4551, 2020, 13:3, orcid:0000-0002-0553-8067 orcid:0000-0002-3292-7471 orcid:0000-0002-1630-3167 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169223 doi:10.1016/j.waojou.2020.100110 PMID 32206161 ISI:000528838100007 Scopus 2-s2.0-85081702790 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.waojou.2020.100110 |
container_title |
World Allergy Organization Journal |
container_volume |
13 |
container_issue |
3 |
container_start_page |
100110 |
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1779318327376609280 |