GWAS studies reveal a possible genetic link between cancer and suicide attempt
Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disor...
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Umeå universitet, Psykiatri
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ftumeauniv:oai:DiVA.org:umu-167059 2023-10-09T21:52:57+02:00 GWAS studies reveal a possible genetic link between cancer and suicide attempt Voskarides, Konstantinos Chatzittofis, Andreas 2019 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167059 https://doi.org/10.1038/s41598-019-54812-9 eng eng Umeå universitet, Psykiatri Medical School, University of Cyprus, Nicosia, Cyprus Scientific Reports, 2019, 9, orcid:0000-0002-3705-3451 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167059 doi:10.1038/s41598-019-54812-9 PMID 31797972 ISI:000501456900001 Scopus 2-s2.0-85076011598 info:eu-repo/semantics/openAccess Medical Genetics Medicinsk genetik Cancer and Oncology Cancer och onkologi Article in journal info:eu-repo/semantics/article text 2019 ftumeauniv https://doi.org/10.1038/s41598-019-54812-9 2023-09-22T13:59:23Z Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10−5; oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10−22), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographical regions (adjusted R2 = 0.135, p = 3.00 × 10−4); this is not the case for other mental disorders. Our results show a possible genetic link between suicide attempt and cancer and a possible evolutionary connection of both diseases with extreme cold environments. These data are useful for future molecular studies or even for investigation of possible therapeutic protocols. Article in Journal/Newspaper inuit Umeå University: Publications (DiVA) Scientific Reports 9 1 |
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collection |
Umeå University: Publications (DiVA) |
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ftumeauniv |
language |
English |
topic |
Medical Genetics Medicinsk genetik Cancer and Oncology Cancer och onkologi |
spellingShingle |
Medical Genetics Medicinsk genetik Cancer and Oncology Cancer och onkologi Voskarides, Konstantinos Chatzittofis, Andreas GWAS studies reveal a possible genetic link between cancer and suicide attempt |
topic_facet |
Medical Genetics Medicinsk genetik Cancer and Oncology Cancer och onkologi |
description |
Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10−5; oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10−22), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographical regions (adjusted R2 = 0.135, p = 3.00 × 10−4); this is not the case for other mental disorders. Our results show a possible genetic link between suicide attempt and cancer and a possible evolutionary connection of both diseases with extreme cold environments. These data are useful for future molecular studies or even for investigation of possible therapeutic protocols. |
format |
Article in Journal/Newspaper |
author |
Voskarides, Konstantinos Chatzittofis, Andreas |
author_facet |
Voskarides, Konstantinos Chatzittofis, Andreas |
author_sort |
Voskarides, Konstantinos |
title |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_short |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_full |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_fullStr |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_full_unstemmed |
GWAS studies reveal a possible genetic link between cancer and suicide attempt |
title_sort |
gwas studies reveal a possible genetic link between cancer and suicide attempt |
publisher |
Umeå universitet, Psykiatri |
publishDate |
2019 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167059 https://doi.org/10.1038/s41598-019-54812-9 |
genre |
inuit |
genre_facet |
inuit |
op_relation |
Scientific Reports, 2019, 9, orcid:0000-0002-3705-3451 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167059 doi:10.1038/s41598-019-54812-9 PMID 31797972 ISI:000501456900001 Scopus 2-s2.0-85076011598 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-019-54812-9 |
container_title |
Scientific Reports |
container_volume |
9 |
container_issue |
1 |
_version_ |
1779316161215725568 |