Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways
The aim of this thesis was to investigate the involvement of the insulin-like growth factor- and the one-carbon metabolism pathways in prostate cancer aetiology, studying both circulating biomarkers and genetic variation. Papers included in the thesis were conducted within the case-control study CAn...
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Umeå universitet, Institutionen för kirurgisk och perioperativ vetenskap
2008
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ftumeauniv:oai:DiVA.org:umu-1645 2023-10-09T21:54:37+02:00 Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways Johansson, Mattias 2008 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1645 eng eng Umeå universitet, Institutionen för kirurgisk och perioperativ vetenskap Umeå : Kirurgisk och perioperativ vetenskap Umeå University medical dissertations, 0346-6612 1165 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1645 urn:isbn:978-91-7264-534-9 info:eu-repo/semantics/openAccess Urology and Nephrology Urologi och njurmedicin Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2008 ftumeauniv 2023-09-22T13:52:11Z The aim of this thesis was to investigate the involvement of the insulin-like growth factor- and the one-carbon metabolism pathways in prostate cancer aetiology, studying both circulating biomarkers and genetic variation. Papers included in the thesis were conducted within the case-control study CAncer Prostate in Sweden (CAPS), and the two prospective studies European Prospective Investigation into nutrition and Cancer (EPIC), and Northern Sweden Health and Disease Cohort (NSHDC). In paper I, we investigated the relation between genetic variants of the IGF1 gene and prostate cancer risk within the CAPS study. We found that a common haplotype within the 3’ region of the IGF1 gene is associated with increased prostate cancer risk. In paper II, we investigated if the variants of the IGF1 gene that were associated with prostate cancer risk in paper I, are also associated with circulating levels of IGF1. Circulating levels of IGF1 were analysed in controls from the CAPS study and three haplotype tagging SNPs (htSNPs) were genotyped in subjects from the NSHDC study in which circulating IGF1 had previously been analysed. The genetic variants previously associated with increased prostate cancer risk were now also found to be associated with elevated levels of circulating IGF1. We concluded that variation in the 3’ region of the IGF1 gene affects prostate cancer risk by influencing circulating levels of IGF1. In paper III, we investigated if variants of the IGFBP1, IGFBP3 and IGFALS genes are associated with i) prostate cancer risk, ii) circulating concentrations of total and intact IGFBP3, and iii) prostate cancer-specific survival probability. In addition, we investigated if circulating concentrations of total and intact IGFBP3 are associated with prostate cancer-specific survival probability. No association between genetic variation and overall prostate cancer risk or survival was observed, but we found a strong association between elevated levels of intact IGFBP3 and increased risk of prostate cancer-specific death. ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
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Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Urology and Nephrology Urologi och njurmedicin |
spellingShingle |
Urology and Nephrology Urologi och njurmedicin Johansson, Mattias Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways |
topic_facet |
Urology and Nephrology Urologi och njurmedicin |
description |
The aim of this thesis was to investigate the involvement of the insulin-like growth factor- and the one-carbon metabolism pathways in prostate cancer aetiology, studying both circulating biomarkers and genetic variation. Papers included in the thesis were conducted within the case-control study CAncer Prostate in Sweden (CAPS), and the two prospective studies European Prospective Investigation into nutrition and Cancer (EPIC), and Northern Sweden Health and Disease Cohort (NSHDC). In paper I, we investigated the relation between genetic variants of the IGF1 gene and prostate cancer risk within the CAPS study. We found that a common haplotype within the 3’ region of the IGF1 gene is associated with increased prostate cancer risk. In paper II, we investigated if the variants of the IGF1 gene that were associated with prostate cancer risk in paper I, are also associated with circulating levels of IGF1. Circulating levels of IGF1 were analysed in controls from the CAPS study and three haplotype tagging SNPs (htSNPs) were genotyped in subjects from the NSHDC study in which circulating IGF1 had previously been analysed. The genetic variants previously associated with increased prostate cancer risk were now also found to be associated with elevated levels of circulating IGF1. We concluded that variation in the 3’ region of the IGF1 gene affects prostate cancer risk by influencing circulating levels of IGF1. In paper III, we investigated if variants of the IGFBP1, IGFBP3 and IGFALS genes are associated with i) prostate cancer risk, ii) circulating concentrations of total and intact IGFBP3, and iii) prostate cancer-specific survival probability. In addition, we investigated if circulating concentrations of total and intact IGFBP3 are associated with prostate cancer-specific survival probability. No association between genetic variation and overall prostate cancer risk or survival was observed, but we found a strong association between elevated levels of intact IGFBP3 and increased risk of prostate cancer-specific death. ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Johansson, Mattias |
author_facet |
Johansson, Mattias |
author_sort |
Johansson, Mattias |
title |
Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways |
title_short |
Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways |
title_full |
Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways |
title_fullStr |
Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways |
title_full_unstemmed |
Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways |
title_sort |
prostate cancer aetiology : epidemiological studies of the igf- and one-carbon metabolism pathways |
publisher |
Umeå universitet, Institutionen för kirurgisk och perioperativ vetenskap |
publishDate |
2008 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1645 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 1165 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1645 urn:isbn:978-91-7264-534-9 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318260724924416 |