Dairy Products and Cancer Risk in a Northern Sweden Population
The role of dairy products in cancer is unclear. We assessed consumption of fermented milk, non-fermented milk, cheese, and butter, estimated from semi-quantitative food frequency questionnaires, in relation to prospective risk of breast, prostate, colorectal, smoking-, and obesity-related cancers i...
Published in: | Nutrition and Cancer |
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Umeå universitet, Näringsforskning
2020
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161682 https://doi.org/10.1080/01635581.2019.1637441 |
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ftumeauniv:oai:DiVA.org:umu-161682 2023-10-09T21:54:30+02:00 Dairy Products and Cancer Risk in a Northern Sweden Population Nilsson, Lena Maria Winkvist, Anna Esberg, Anders Jansson, Jan-Håkan Wennberg, Patrik van Guelpen, Bethany Johansson, Ingegerd 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161682 https://doi.org/10.1080/01635581.2019.1637441 eng eng Umeå universitet, Näringsforskning Umeå universitet, Institutionen för odontologi Umeå universitet, Avdelningen för medicin Umeå universitet, Allmänmedicin Umeå universitet, Onkologi Umeå universitet, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM) Nutrition and Cancer, 0163-5581, 2020, 72:3, s. 409-420 orcid:0000-0002-2354-7258 orcid:0000-0002-4430-8125 orcid:0000-0003-1962-5484 orcid:0000-0002-1617-6102 orcid:0000-0002-9692-101X orcid:0000-0002-9227-8434 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161682 doi:10.1080/01635581.2019.1637441 PMID 31298944 ISI:000476072800001 Scopus 2-s2.0-85068900342 info:eu-repo/semantics/openAccess dairy products milk cheese fermented milk cancer Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.1080/01635581.2019.1637441 2023-09-22T13:58:21Z The role of dairy products in cancer is unclear. We assessed consumption of fermented milk, non-fermented milk, cheese, and butter, estimated from semi-quantitative food frequency questionnaires, in relation to prospective risk of breast, prostate, colorectal, smoking-, and obesity-related cancers in 101,235 subjects, including 12,552 cancer cases, in the population-based Northern Sweden Health and Disease Study. Most analyses (n = 20) rendered null results. In men, we observed an increased prostate cancer risk among high-consumers of cheese (hazard ratio (HR) for highest vs. lowest quintile (Q5-Q1), 1.11; 95% CI, 0.97-1.27; Ptrend = 0.013). In women, high-consumers of cheese had a decreased risk of overall cancer (HR Q5-Q1, 0.95; 95% CI, 0.88-1.04; Ptrend = 0.039), smoking-related (HR Q5-Q1, 0.84; 95% CI, 0.72-0.97; Ptrend ≤ 0.001), and colorectal cancers (HR Q5-Q1, 0.82; 95% CI, 0.63-1.07; Ptrend = 0.048). Butter yielded a weak decreased obesity-related cancer risk in women (HR Q5-Q1, 0.91; 95% CI, 0.81-1.02; Ptrend = 0.049). Fermented milk yielded HRs below zero in women, but with no clear linear associations. In conclusion, this study does not support any major adverse or beneficial effects of fermented milk, non-fermented milk, cheese, and butter in the diet from a cancer risk perspective. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Nutrition and Cancer 72 3 409 420 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
dairy products milk cheese fermented milk cancer Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
dairy products milk cheese fermented milk cancer Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Nilsson, Lena Maria Winkvist, Anna Esberg, Anders Jansson, Jan-Håkan Wennberg, Patrik van Guelpen, Bethany Johansson, Ingegerd Dairy Products and Cancer Risk in a Northern Sweden Population |
topic_facet |
dairy products milk cheese fermented milk cancer Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
The role of dairy products in cancer is unclear. We assessed consumption of fermented milk, non-fermented milk, cheese, and butter, estimated from semi-quantitative food frequency questionnaires, in relation to prospective risk of breast, prostate, colorectal, smoking-, and obesity-related cancers in 101,235 subjects, including 12,552 cancer cases, in the population-based Northern Sweden Health and Disease Study. Most analyses (n = 20) rendered null results. In men, we observed an increased prostate cancer risk among high-consumers of cheese (hazard ratio (HR) for highest vs. lowest quintile (Q5-Q1), 1.11; 95% CI, 0.97-1.27; Ptrend = 0.013). In women, high-consumers of cheese had a decreased risk of overall cancer (HR Q5-Q1, 0.95; 95% CI, 0.88-1.04; Ptrend = 0.039), smoking-related (HR Q5-Q1, 0.84; 95% CI, 0.72-0.97; Ptrend ≤ 0.001), and colorectal cancers (HR Q5-Q1, 0.82; 95% CI, 0.63-1.07; Ptrend = 0.048). Butter yielded a weak decreased obesity-related cancer risk in women (HR Q5-Q1, 0.91; 95% CI, 0.81-1.02; Ptrend = 0.049). Fermented milk yielded HRs below zero in women, but with no clear linear associations. In conclusion, this study does not support any major adverse or beneficial effects of fermented milk, non-fermented milk, cheese, and butter in the diet from a cancer risk perspective. |
format |
Article in Journal/Newspaper |
author |
Nilsson, Lena Maria Winkvist, Anna Esberg, Anders Jansson, Jan-Håkan Wennberg, Patrik van Guelpen, Bethany Johansson, Ingegerd |
author_facet |
Nilsson, Lena Maria Winkvist, Anna Esberg, Anders Jansson, Jan-Håkan Wennberg, Patrik van Guelpen, Bethany Johansson, Ingegerd |
author_sort |
Nilsson, Lena Maria |
title |
Dairy Products and Cancer Risk in a Northern Sweden Population |
title_short |
Dairy Products and Cancer Risk in a Northern Sweden Population |
title_full |
Dairy Products and Cancer Risk in a Northern Sweden Population |
title_fullStr |
Dairy Products and Cancer Risk in a Northern Sweden Population |
title_full_unstemmed |
Dairy Products and Cancer Risk in a Northern Sweden Population |
title_sort |
dairy products and cancer risk in a northern sweden population |
publisher |
Umeå universitet, Näringsforskning |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161682 https://doi.org/10.1080/01635581.2019.1637441 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Nutrition and Cancer, 0163-5581, 2020, 72:3, s. 409-420 orcid:0000-0002-2354-7258 orcid:0000-0002-4430-8125 orcid:0000-0003-1962-5484 orcid:0000-0002-1617-6102 orcid:0000-0002-9692-101X orcid:0000-0002-9227-8434 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161682 doi:10.1080/01635581.2019.1637441 PMID 31298944 ISI:000476072800001 Scopus 2-s2.0-85068900342 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/01635581.2019.1637441 |
container_title |
Nutrition and Cancer |
container_volume |
72 |
container_issue |
3 |
container_start_page |
409 |
op_container_end_page |
420 |
_version_ |
1779318090888118272 |