Epidemiology of venous thromboembolism with focus on risk markers
Background: Venous thromboembolism (VTE) is a vascular disease with an incidence of approximately 140 cases per 100,000 person-years in adults. The incidence of VTE has increased over the last decades, and more than 20% of affected individuals die in the first year after diagnosis. To reduce the inc...
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Umeå universitet, Institutionen för folkhälsa och klinisk medicin
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ftumeauniv:oai:DiVA.org:umu-158474 2023-10-09T21:54:38+02:00 Epidemiology of venous thromboembolism with focus on risk markers Venös tromboembolism – epidemiologi med fokus på riskmarkörer Johansson, Magdalena 2019 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158474 eng eng Umeå universitet, Institutionen för folkhälsa och klinisk medicin Umeå : Umeå University Umeå University medical dissertations, 0346-6612 2024 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158474 urn:isbn:978-91-7855-041-8 info:eu-repo/semantics/openAccess Venous thromboembolism venous thrombosis deep vein thrombosis pulmonary embolism incidence risk markers diabetes glucose alcohol consumption alcohol dependence physical activity Other Clinical Medicine Annan klinisk medicin Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2019 ftumeauniv 2023-09-22T13:51:35Z Background: Venous thromboembolism (VTE) is a vascular disease with an incidence of approximately 140 cases per 100,000 person-years in adults. The incidence of VTE has increased over the last decades, and more than 20% of affected individuals die in the first year after diagnosis. To reduce the incidence of VTE, it is important to identify modifiable risk factors for the condition. Aims: The aims of this thesis were a) To study the incidence of first-time VTE and the prevalence of risk markers for VTE at the time of VTE diagnosis, b) To determine the validity of diagnoses of deep vein thrombosis and pulmonary embolism in administrative registries, and c) To study the association between glucose levels, diabetes, alcohol consumption, physical activity and risk of first-time VTE. Methods: To determine the incidence of first-time VTE and the prevalence of risk markers for VTE at the time of VTE diagnosis, a retrospective, population-based cohort study was conducted. The study included all adult residents of Västerbotten County during the year 2006. All other aims were addressed in the prospective, population-based Venous thromboEmbolism In Northern Sweden (VEINS) cohort study. The VEINS cohort included 108,025 residents of Västerbotten County aged 30 to 60 years without previous VTE events. They were included from 1985 onwards and were followed until a VTE event, death, emigration, or the study end on September 5, 2014. All underwent a health examination within the Västerbotten Intervention Programme where weight, height, blood pressure and glucose levels were measured, and answered a questionnaire regarding smoking, education level, medication use, history of diabetes, alcohol intake and physical activity. VTE diagnoses were validated by review of medical records and radiology reports. To study the validity of diagnoses of deep vein thrombosis and pulmonary embolism in administrative registries, a registry search for International Classification of Diseases diagnosis codes indicating pulmonary embolism and/or ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Venous thromboembolism venous thrombosis deep vein thrombosis pulmonary embolism incidence risk markers diabetes glucose alcohol consumption alcohol dependence physical activity Other Clinical Medicine Annan klinisk medicin |
spellingShingle |
Venous thromboembolism venous thrombosis deep vein thrombosis pulmonary embolism incidence risk markers diabetes glucose alcohol consumption alcohol dependence physical activity Other Clinical Medicine Annan klinisk medicin Johansson, Magdalena Epidemiology of venous thromboembolism with focus on risk markers |
topic_facet |
Venous thromboembolism venous thrombosis deep vein thrombosis pulmonary embolism incidence risk markers diabetes glucose alcohol consumption alcohol dependence physical activity Other Clinical Medicine Annan klinisk medicin |
description |
Background: Venous thromboembolism (VTE) is a vascular disease with an incidence of approximately 140 cases per 100,000 person-years in adults. The incidence of VTE has increased over the last decades, and more than 20% of affected individuals die in the first year after diagnosis. To reduce the incidence of VTE, it is important to identify modifiable risk factors for the condition. Aims: The aims of this thesis were a) To study the incidence of first-time VTE and the prevalence of risk markers for VTE at the time of VTE diagnosis, b) To determine the validity of diagnoses of deep vein thrombosis and pulmonary embolism in administrative registries, and c) To study the association between glucose levels, diabetes, alcohol consumption, physical activity and risk of first-time VTE. Methods: To determine the incidence of first-time VTE and the prevalence of risk markers for VTE at the time of VTE diagnosis, a retrospective, population-based cohort study was conducted. The study included all adult residents of Västerbotten County during the year 2006. All other aims were addressed in the prospective, population-based Venous thromboEmbolism In Northern Sweden (VEINS) cohort study. The VEINS cohort included 108,025 residents of Västerbotten County aged 30 to 60 years without previous VTE events. They were included from 1985 onwards and were followed until a VTE event, death, emigration, or the study end on September 5, 2014. All underwent a health examination within the Västerbotten Intervention Programme where weight, height, blood pressure and glucose levels were measured, and answered a questionnaire regarding smoking, education level, medication use, history of diabetes, alcohol intake and physical activity. VTE diagnoses were validated by review of medical records and radiology reports. To study the validity of diagnoses of deep vein thrombosis and pulmonary embolism in administrative registries, a registry search for International Classification of Diseases diagnosis codes indicating pulmonary embolism and/or ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Johansson, Magdalena |
author_facet |
Johansson, Magdalena |
author_sort |
Johansson, Magdalena |
title |
Epidemiology of venous thromboembolism with focus on risk markers |
title_short |
Epidemiology of venous thromboembolism with focus on risk markers |
title_full |
Epidemiology of venous thromboembolism with focus on risk markers |
title_fullStr |
Epidemiology of venous thromboembolism with focus on risk markers |
title_full_unstemmed |
Epidemiology of venous thromboembolism with focus on risk markers |
title_sort |
epidemiology of venous thromboembolism with focus on risk markers |
publisher |
Umeå universitet, Institutionen för folkhälsa och klinisk medicin |
publishDate |
2019 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158474 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 2024 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158474 urn:isbn:978-91-7855-041-8 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318300361097216 |