Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study
The aim of this study was to determine the association between individual and external exposure factors, and the reporting of Raynaud’s phenomenon, with or without concomitant cold sensitivity. In a population-based nested case–control study, cases with Raynaud’s phenomenon (N = 578), and matched co...
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Umeå universitet, Yrkes- och miljömedicin
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ftumeauniv:oai:DiVA.org:umu-152083 2023-10-09T21:54:34+02:00 Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study Stjernbrandt, Albin Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens 2019 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152083 https://doi.org/10.1007/s00296-018-4133-y eng eng Umeå universitet, Yrkes- och miljömedicin Rheumatology International, 0172-8172, 2019, 39:2, s. 265-275 orcid:0000-0001-6082-8465 orcid:0000-0002-5936-1172 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152083 doi:10.1007/s00296-018-4133-y PMID 30128730 ISI:000457425100009 Scopus 2-s2.0-85052593180 info:eu-repo/semantics/openAccess Cold exposure Epidemiology Frostbite Hand Occupational exposure Risk factors Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Article in journal info:eu-repo/semantics/article text 2019 ftumeauniv https://doi.org/10.1007/s00296-018-4133-y 2023-09-22T13:57:30Z The aim of this study was to determine the association between individual and external exposure factors, and the reporting of Raynaud’s phenomenon, with or without concomitant cold sensitivity. In a population-based nested case–control study, cases with Raynaud’s phenomenon (N = 578), and matched controls (N = 1156), were asked to respond to a questionnaire focusing on different risk factors. Univariate and multiple conditional logistic regression were performed. Analyses were stratified according to whether the cases reported cold sensitivity or not. In total, 1400 out of 1734 study subjects answered the questionnaire (response rate 80.7%). In the final multiple model, the factor with the strongest association to Raynaud’s phenomenon, with and without cold sensitivity, was previous frostbite affecting the hands (OR 12.44; 95% CI 5.84–26.52 and OR 4.01; 95% CI 1.78–9.01, respectively). Upper extremity nerve injury was associated to reporting Raynaud’s phenomenon and cold sensitivity (OR 2.23; 95% CI 1.29–3.85), but not Raynaud’s phenomenon alone. Reporting any exposure to hand-arm vibration or cumulative cold exposure was significant in univariate analyses for cases with both Raynaud’s phenomenon and cold sensitivity, but not in the multiple model. Raynaud’s phenomenon is strongly associated to previous cold injury, with a larger effect size among those who also report cold sensitivity. The fact that only upper extremity nerve injury differed significantly between case groups in our multiple model offers additional support to the neural basis for cold sensitivity. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Rheumatology International 39 2 265 275 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cold exposure Epidemiology Frostbite Hand Occupational exposure Risk factors Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
spellingShingle |
Cold exposure Epidemiology Frostbite Hand Occupational exposure Risk factors Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Stjernbrandt, Albin Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study |
topic_facet |
Cold exposure Epidemiology Frostbite Hand Occupational exposure Risk factors Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
description |
The aim of this study was to determine the association between individual and external exposure factors, and the reporting of Raynaud’s phenomenon, with or without concomitant cold sensitivity. In a population-based nested case–control study, cases with Raynaud’s phenomenon (N = 578), and matched controls (N = 1156), were asked to respond to a questionnaire focusing on different risk factors. Univariate and multiple conditional logistic regression were performed. Analyses were stratified according to whether the cases reported cold sensitivity or not. In total, 1400 out of 1734 study subjects answered the questionnaire (response rate 80.7%). In the final multiple model, the factor with the strongest association to Raynaud’s phenomenon, with and without cold sensitivity, was previous frostbite affecting the hands (OR 12.44; 95% CI 5.84–26.52 and OR 4.01; 95% CI 1.78–9.01, respectively). Upper extremity nerve injury was associated to reporting Raynaud’s phenomenon and cold sensitivity (OR 2.23; 95% CI 1.29–3.85), but not Raynaud’s phenomenon alone. Reporting any exposure to hand-arm vibration or cumulative cold exposure was significant in univariate analyses for cases with both Raynaud’s phenomenon and cold sensitivity, but not in the multiple model. Raynaud’s phenomenon is strongly associated to previous cold injury, with a larger effect size among those who also report cold sensitivity. The fact that only upper extremity nerve injury differed significantly between case groups in our multiple model offers additional support to the neural basis for cold sensitivity. |
format |
Article in Journal/Newspaper |
author |
Stjernbrandt, Albin Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens |
author_facet |
Stjernbrandt, Albin Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens |
author_sort |
Stjernbrandt, Albin |
title |
Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study |
title_short |
Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study |
title_full |
Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study |
title_fullStr |
Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study |
title_full_unstemmed |
Raynaud's phenomenon in Northern Sweden : a population-based nested case-control study |
title_sort |
raynaud's phenomenon in northern sweden : a population-based nested case-control study |
publisher |
Umeå universitet, Yrkes- och miljömedicin |
publishDate |
2019 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152083 https://doi.org/10.1007/s00296-018-4133-y |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Rheumatology International, 0172-8172, 2019, 39:2, s. 265-275 orcid:0000-0001-6082-8465 orcid:0000-0002-5936-1172 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152083 doi:10.1007/s00296-018-4133-y PMID 30128730 ISI:000457425100009 Scopus 2-s2.0-85052593180 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s00296-018-4133-y |
container_title |
Rheumatology International |
container_volume |
39 |
container_issue |
2 |
container_start_page |
265 |
op_container_end_page |
275 |
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1779318186254008320 |