Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden
Aim To identify possible risk factors for cold sensitivity, by comparing cases to controls with regard to demographic and anthropometric characteristics, previous illnesses and injuries as well as ambient exposures. Methods Through a questionnaire responded to by the general population (n=12,627) co...
Published in: | International Archives of Occupational and Environmental Health |
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Umeå universitet, Yrkes- och miljömedicin
2018
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ftumeauniv:oai:DiVA.org:umu-141016 2023-10-09T21:54:31+02:00 Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden Stjernbrandt, Albin Carlsson, Daniel Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens 2018 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141016 https://doi.org/10.1007/s00420-018-1327-2 eng eng Umeå universitet, Yrkes- och miljömedicin Occupational and Environmental Medicine, University Hospital of Umeå, 901 85, Umeå, Sweden. International Archives of Occupational and Environmental Health, 0340-0131, 2018, 91:7, s. 785-797 orcid:0000-0001-6082-8465 orcid:0000-0002-5936-1172 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141016 doi:10.1007/s00420-018-1327-2 PMID 29808434 ISI:000443357600002 Scopus 2-s2.0-85047665099 info:eu-repo/semantics/openAccess Cold exposure Cold sensitivity Frostbite Hand Raynaud’s phenomenon Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Article in journal info:eu-repo/semantics/article text 2018 ftumeauniv https://doi.org/10.1007/s00420-018-1327-2 2023-09-22T13:56:33Z Aim To identify possible risk factors for cold sensitivity, by comparing cases to controls with regard to demographic and anthropometric characteristics, previous illnesses and injuries as well as ambient exposures. Methods Through a questionnaire responded to by the general population (n=12,627) cold sensitivity cases (n=502) and matched controls (n=1,004) were identified and asked to respond to a second questionnaire with focus on different aspects of cold sensitivity, hereditary factors, previous diseases, medication, tobacco use as well as exposure to ambient cold climate and hand-arm vibration (HAV). Results In total, 997 out of 1506 study subjects answered the second questionnaire, 374 cases and 623 match controls. Identified risk factors among the cases were frostbite of the hands Odds Ratio (OR) 10.3 (95% confidence interval (CI) 5.5-19.3), rheumatic disease OR 3.1 (95% CI 1.7-5.7), upper extremity nerve injury OR 2.0 (95% CI 1.3-3.0), and vascular disease OR 1.9 (95% CI 1.2-2.9). Sex differences in risk factors were HAV exposure for men and cold exposure for women increased the risk of cold sensitivity. Rheumatic diseases and migraine increased the risk of cold sensitivity among women but not among men. Conclusions The present study shows that cold sensitivity is associated with both inherent factors, acquired conditions and external exposures. Among acquired conditions, frostbite, vascular disease, nerve injury, joint disorders and migraine are significantly related to the reporting of cold sensitivity. Among external exposures, both cold climate and HAV exposure are significantly associated to cold sensitivity, and thus suitable targets for primary preventive measures. There was a difference in risk factors related to sex. HAV exposure for men and cold exposure for women increased the risk of cold sensitivity. Originally included in thesis in manuscript form with title [Cold sensitivity and associated factors: a case-control study performed in northern Sweden] CHINS Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) International Archives of Occupational and Environmental Health 91 7 785 797 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cold exposure Cold sensitivity Frostbite Hand Raynaud’s phenomenon Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
spellingShingle |
Cold exposure Cold sensitivity Frostbite Hand Raynaud’s phenomenon Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Stjernbrandt, Albin Carlsson, Daniel Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden |
topic_facet |
Cold exposure Cold sensitivity Frostbite Hand Raynaud’s phenomenon Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
description |
Aim To identify possible risk factors for cold sensitivity, by comparing cases to controls with regard to demographic and anthropometric characteristics, previous illnesses and injuries as well as ambient exposures. Methods Through a questionnaire responded to by the general population (n=12,627) cold sensitivity cases (n=502) and matched controls (n=1,004) were identified and asked to respond to a second questionnaire with focus on different aspects of cold sensitivity, hereditary factors, previous diseases, medication, tobacco use as well as exposure to ambient cold climate and hand-arm vibration (HAV). Results In total, 997 out of 1506 study subjects answered the second questionnaire, 374 cases and 623 match controls. Identified risk factors among the cases were frostbite of the hands Odds Ratio (OR) 10.3 (95% confidence interval (CI) 5.5-19.3), rheumatic disease OR 3.1 (95% CI 1.7-5.7), upper extremity nerve injury OR 2.0 (95% CI 1.3-3.0), and vascular disease OR 1.9 (95% CI 1.2-2.9). Sex differences in risk factors were HAV exposure for men and cold exposure for women increased the risk of cold sensitivity. Rheumatic diseases and migraine increased the risk of cold sensitivity among women but not among men. Conclusions The present study shows that cold sensitivity is associated with both inherent factors, acquired conditions and external exposures. Among acquired conditions, frostbite, vascular disease, nerve injury, joint disorders and migraine are significantly related to the reporting of cold sensitivity. Among external exposures, both cold climate and HAV exposure are significantly associated to cold sensitivity, and thus suitable targets for primary preventive measures. There was a difference in risk factors related to sex. HAV exposure for men and cold exposure for women increased the risk of cold sensitivity. Originally included in thesis in manuscript form with title [Cold sensitivity and associated factors: a case-control study performed in northern Sweden] CHINS |
format |
Article in Journal/Newspaper |
author |
Stjernbrandt, Albin Carlsson, Daniel Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens |
author_facet |
Stjernbrandt, Albin Carlsson, Daniel Pettersson, Hans Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens |
author_sort |
Stjernbrandt, Albin |
title |
Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden |
title_short |
Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden |
title_full |
Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden |
title_fullStr |
Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden |
title_full_unstemmed |
Cold sensitivity and associated factors : a nested case–control study performed in Northern Sweden |
title_sort |
cold sensitivity and associated factors : a nested case–control study performed in northern sweden |
publisher |
Umeå universitet, Yrkes- och miljömedicin |
publishDate |
2018 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141016 https://doi.org/10.1007/s00420-018-1327-2 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
International Archives of Occupational and Environmental Health, 0340-0131, 2018, 91:7, s. 785-797 orcid:0000-0001-6082-8465 orcid:0000-0002-5936-1172 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141016 doi:10.1007/s00420-018-1327-2 PMID 29808434 ISI:000443357600002 Scopus 2-s2.0-85047665099 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s00420-018-1327-2 |
container_title |
International Archives of Occupational and Environmental Health |
container_volume |
91 |
container_issue |
7 |
container_start_page |
785 |
op_container_end_page |
797 |
_version_ |
1779318113671577600 |