Distribution of puumala virus in Sweden
Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. In Sweden, NE is reported from the northern an...
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Umeå universitet, Infektionssjukdomar
1997
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ftumeauniv:oai:DiVA.org:umu-140825 2023-10-09T21:54:31+02:00 Distribution of puumala virus in Sweden Ahlm, Clas 1997 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140825 eng eng Umeå universitet, Infektionssjukdomar Umeå : Umeå universitet Umeå University medical dissertations, 0346-6612 536 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140825 urn:isbn:91-7191-404-8 info:eu-repo/semantics/openAccess Infectious Medicine Infektionsmedicin Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 1997 ftumeauniv 2023-09-22T13:49:53Z Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. In Sweden, NE is reported from the northern and central parts but virtually not at all from the southern part of the country. The bank vole (Clethrionomys glareolus) is the main reservoir of Puumala virus and humans are infected by inhalation of aerosolized animal secreta. In northern Sweden, the density of the bank vole population varies cyclically in intervals of 3-4 years and the incidence of NE shows a covariation. The prevalence of serum antibodies to hantaviruses in northern Sweden was studied in a stratified and randomly selected adult population sample comprising 1538 subjects. As expected, the prevalence increased with age. There was no difference between men and women, which was unexpected based on a male:female ratio of > 2:1 in clinical reports. By use of an immunofiuorescent assay, a seroprevalence of 5.4% and by a newly developed enzyme-linked immunosorbent assay (ELISA) with recombinant Puumala virus nucleocapsid protein as antigen, a prevalence of 8.9% was recorded. This is about or more than ten times higher than what would be calculated from clinical reports. By use of the ELISA, an occupational risk of acquisition of Puumala virus infection was demonstrated. Serum samples from 910 farmers and 663 referent subjects living in various rural parts of Sweden were tested. Among farmers from the Puumala virus-endemic northern and central parts of the country, the seroprevalence (12.9%) was higher (p=0.01) than in referents (6.8%). In the southern part of Sweden, only 2/459 persons had antibodies. Only a limited number of children with NE had been previously reported. In a separate study, 32 children with Puumala virus infection were identified and the clinical picture of NE in children was found to be similar to that of adult cases. Variations in ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Infectious Medicine Infektionsmedicin |
spellingShingle |
Infectious Medicine Infektionsmedicin Ahlm, Clas Distribution of puumala virus in Sweden |
topic_facet |
Infectious Medicine Infektionsmedicin |
description |
Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. In Sweden, NE is reported from the northern and central parts but virtually not at all from the southern part of the country. The bank vole (Clethrionomys glareolus) is the main reservoir of Puumala virus and humans are infected by inhalation of aerosolized animal secreta. In northern Sweden, the density of the bank vole population varies cyclically in intervals of 3-4 years and the incidence of NE shows a covariation. The prevalence of serum antibodies to hantaviruses in northern Sweden was studied in a stratified and randomly selected adult population sample comprising 1538 subjects. As expected, the prevalence increased with age. There was no difference between men and women, which was unexpected based on a male:female ratio of > 2:1 in clinical reports. By use of an immunofiuorescent assay, a seroprevalence of 5.4% and by a newly developed enzyme-linked immunosorbent assay (ELISA) with recombinant Puumala virus nucleocapsid protein as antigen, a prevalence of 8.9% was recorded. This is about or more than ten times higher than what would be calculated from clinical reports. By use of the ELISA, an occupational risk of acquisition of Puumala virus infection was demonstrated. Serum samples from 910 farmers and 663 referent subjects living in various rural parts of Sweden were tested. Among farmers from the Puumala virus-endemic northern and central parts of the country, the seroprevalence (12.9%) was higher (p=0.01) than in referents (6.8%). In the southern part of Sweden, only 2/459 persons had antibodies. Only a limited number of children with NE had been previously reported. In a separate study, 32 children with Puumala virus infection were identified and the clinical picture of NE in children was found to be similar to that of adult cases. Variations in ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Ahlm, Clas |
author_facet |
Ahlm, Clas |
author_sort |
Ahlm, Clas |
title |
Distribution of puumala virus in Sweden |
title_short |
Distribution of puumala virus in Sweden |
title_full |
Distribution of puumala virus in Sweden |
title_fullStr |
Distribution of puumala virus in Sweden |
title_full_unstemmed |
Distribution of puumala virus in Sweden |
title_sort |
distribution of puumala virus in sweden |
publisher |
Umeå universitet, Infektionssjukdomar |
publishDate |
1997 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140825 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 536 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140825 urn:isbn:91-7191-404-8 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318116740759552 |