High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study
INTRODUCTION: High blood pressure (BP) increases the risk of stroke, but there is limited evidence from studies including very old people. The aim was to investigate risk factors for incident stroke among very old people. METHODS: A prospective population-based cohort study was performed among parti...
Published in: | Journal of Hypertension |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Umeå universitet, Geriatrik
2016
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128531 https://doi.org/10.1097/HJH.0000000000001048 |
id |
ftumeauniv:oai:DiVA.org:umu-128531 |
---|---|
record_format |
openpolar |
spelling |
ftumeauniv:oai:DiVA.org:umu-128531 2023-10-09T21:54:36+02:00 High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study Hörnsten, Carl Weidung, Bodil Littbrand, Håkan Carlberg, Bo Nordström, Peter Lövheim, Hugo Gustafson, Yngve 2016 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128531 https://doi.org/10.1097/HJH.0000000000001048 eng eng Umeå universitet, Geriatrik Umeå universitet, Medicin Journal of Hypertension, 0263-6352, 2016, 34:10, s. 2059-2065 orcid:0000-0003-2924-508X http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128531 doi:10.1097/HJH.0000000000001048 PMID 27434102 ISI:000384032800017 Scopus 2-s2.0-84978696405 info:eu-repo/semantics/openAccess 80 and over aged atrial fibrillation blood pressure cerebrovascular disorders risk factors stroke very old Geriatrics Geriatrik Article in journal info:eu-repo/semantics/article text 2016 ftumeauniv https://doi.org/10.1097/HJH.0000000000001048 2023-09-22T13:57:41Z INTRODUCTION: High blood pressure (BP) increases the risk of stroke, but there is limited evidence from studies including very old people. The aim was to investigate risk factors for incident stroke among very old people. METHODS: A prospective population-based cohort study was performed among participants aged at least 85 years in northern Sweden. The 955 participants were tested at their homes. BP was measured manually after 5-min supine rest. Incident stroke data were collected from medical charts guided by hospital registry, death records, and 5-year reassessments. Cox proportional hazards models were used. RESULTS: The stroke incidence was 33.8/1000 person-years (94 stroke events) during a mean follow-up period of 2.9 years. In a comprehensive multivariate model, atrial fibrillation [hazard ratio 1.85, 95% confidence interval (CI) 1.07-3.19] and higher SBP (hazard ratio 1.19, 95% CI 1.08-1.30 per 10-mmHg increase) were associated with incident stroke overall. However, higher SBP was not associated with incident stroke in participants with SBP less than 140 mmHg (hazard ratio 0.90, 95% CI 0.53-1.53 per 10-mmHg increase). In additional multivariate models, DBP at least 90 mmHg (hazard ratio 2.45, 95% CI 1.47-4.08) and SBP at least 160 mmHg (vs. <140 mmHg; hazard ratio 2.80, 95% CI 1.53-5.14) were associated with incident stroke. The association between BP and incident stroke was not affected by interactions related to sex, dependence in activities of daily living, or cognitive impairment. CONCLUSION: High SBP (≥160 mmHg) and DBP (≥90 mmHg) and atrial fibrillation appeared to be risk factors for incident stroke among very old people. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Journal of Hypertension 34 10 2059 2065 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
80 and over aged atrial fibrillation blood pressure cerebrovascular disorders risk factors stroke very old Geriatrics Geriatrik |
spellingShingle |
80 and over aged atrial fibrillation blood pressure cerebrovascular disorders risk factors stroke very old Geriatrics Geriatrik Hörnsten, Carl Weidung, Bodil Littbrand, Håkan Carlberg, Bo Nordström, Peter Lövheim, Hugo Gustafson, Yngve High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
topic_facet |
80 and over aged atrial fibrillation blood pressure cerebrovascular disorders risk factors stroke very old Geriatrics Geriatrik |
description |
INTRODUCTION: High blood pressure (BP) increases the risk of stroke, but there is limited evidence from studies including very old people. The aim was to investigate risk factors for incident stroke among very old people. METHODS: A prospective population-based cohort study was performed among participants aged at least 85 years in northern Sweden. The 955 participants were tested at their homes. BP was measured manually after 5-min supine rest. Incident stroke data were collected from medical charts guided by hospital registry, death records, and 5-year reassessments. Cox proportional hazards models were used. RESULTS: The stroke incidence was 33.8/1000 person-years (94 stroke events) during a mean follow-up period of 2.9 years. In a comprehensive multivariate model, atrial fibrillation [hazard ratio 1.85, 95% confidence interval (CI) 1.07-3.19] and higher SBP (hazard ratio 1.19, 95% CI 1.08-1.30 per 10-mmHg increase) were associated with incident stroke overall. However, higher SBP was not associated with incident stroke in participants with SBP less than 140 mmHg (hazard ratio 0.90, 95% CI 0.53-1.53 per 10-mmHg increase). In additional multivariate models, DBP at least 90 mmHg (hazard ratio 2.45, 95% CI 1.47-4.08) and SBP at least 160 mmHg (vs. <140 mmHg; hazard ratio 2.80, 95% CI 1.53-5.14) were associated with incident stroke. The association between BP and incident stroke was not affected by interactions related to sex, dependence in activities of daily living, or cognitive impairment. CONCLUSION: High SBP (≥160 mmHg) and DBP (≥90 mmHg) and atrial fibrillation appeared to be risk factors for incident stroke among very old people. |
format |
Article in Journal/Newspaper |
author |
Hörnsten, Carl Weidung, Bodil Littbrand, Håkan Carlberg, Bo Nordström, Peter Lövheim, Hugo Gustafson, Yngve |
author_facet |
Hörnsten, Carl Weidung, Bodil Littbrand, Håkan Carlberg, Bo Nordström, Peter Lövheim, Hugo Gustafson, Yngve |
author_sort |
Hörnsten, Carl |
title |
High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
title_short |
High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
title_full |
High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
title_fullStr |
High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
title_full_unstemmed |
High blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
title_sort |
high blood pressure as a risk factor for incident stroke among very old people : a population-based cohort study |
publisher |
Umeå universitet, Geriatrik |
publishDate |
2016 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128531 https://doi.org/10.1097/HJH.0000000000001048 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Journal of Hypertension, 0263-6352, 2016, 34:10, s. 2059-2065 orcid:0000-0003-2924-508X http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128531 doi:10.1097/HJH.0000000000001048 PMID 27434102 ISI:000384032800017 Scopus 2-s2.0-84978696405 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1097/HJH.0000000000001048 |
container_title |
Journal of Hypertension |
container_volume |
34 |
container_issue |
10 |
container_start_page |
2059 |
op_container_end_page |
2065 |
_version_ |
1779318235706949632 |