Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum
Low vitamin D levels during pregnancy may have negative consequences for the health of both the mother and child. Cross-sectional studies in childbearing women suggest that vitamin D levels are low during pregnancy, but few studies have followed the same women during pregnancy and postpartum. The ai...
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Umeå universitet, Allmänmedicin
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ftumeauniv:oai:DiVA.org:umu-117426 2023-10-09T21:54:35+02:00 Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum Lundqvist, Anette Sandström, Herbert Stenlund, Hans Johansson, Ingegerd Hultdin, Johan 2016 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117426 https://doi.org/10.1371/journal.pone.0150385 eng eng Umeå universitet, Allmänmedicin Umeå universitet, Epidemiologi och global hälsa Umeå universitet, Institutionen för odontologi Umeå universitet, Klinisk kemi PLOS ONE, 2016, 11:3, orcid:0000-0003-1730-699x http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117426 doi:10.1371/journal.pone.0150385 ISI:000371735200077 Scopus 2-s2.0-84961285093 info:eu-repo/semantics/openAccess General Practice Allmänmedicin Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi Article in journal info:eu-repo/semantics/article text 2016 ftumeauniv https://doi.org/10.1371/journal.pone.0150385 2023-09-22T13:57:58Z Low vitamin D levels during pregnancy may have negative consequences for the health of both the mother and child. Cross-sectional studies in childbearing women suggest that vitamin D levels are low during pregnancy, but few studies have followed the same women during pregnancy and postpartum. The aims of this study were to longitudinally assess vitamin D status during pregnancy and postpartum and identify the factors associated with vitamin D status in pregnant women in northern Sweden. Between September 2006 and March 2009, 184 women were consecutively recruited at five antenatal primary care clinics. Blood was sampled, and dietary intake was estimated using a food frequency questionnaire with 66 food items/food aggregates and questions on the intake of vitamin supplements at gestational weeks 12, 21, and 35, as well as at 12 and 29 weeks after birth. Plasma 25(OH) vitamin D levels were analyzed using liquid chromatography tandem-mass spectrometry. At least one-third of the women had 25(OH) vitamin D levels <50 nmol/L on at least one sampling occasion. Plasma levels increased slightly over the gestation period and peaked in late pregnancy. The levels reverted to the baseline levels after birth. Multivariate analysis showed that gestational and postpartum week, season, dietary intake of vitamin D, and vitamin supplementation were significantly related to plasma levels. There was also an influence of season on the longitudinal concentration patterns. In conclusion, more than one-third of the women studied had low 25(OH) vitamin D levels, and gestational and postpartum week was related to 25(OH) vitamin D levels after adjustment for season and vitamin D intake. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) PLOS ONE 11 3 e0150385 |
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Open Polar |
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Umeå University: Publications (DiVA) |
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ftumeauniv |
language |
English |
topic |
General Practice Allmänmedicin Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi |
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General Practice Allmänmedicin Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi Lundqvist, Anette Sandström, Herbert Stenlund, Hans Johansson, Ingegerd Hultdin, Johan Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum |
topic_facet |
General Practice Allmänmedicin Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi |
description |
Low vitamin D levels during pregnancy may have negative consequences for the health of both the mother and child. Cross-sectional studies in childbearing women suggest that vitamin D levels are low during pregnancy, but few studies have followed the same women during pregnancy and postpartum. The aims of this study were to longitudinally assess vitamin D status during pregnancy and postpartum and identify the factors associated with vitamin D status in pregnant women in northern Sweden. Between September 2006 and March 2009, 184 women were consecutively recruited at five antenatal primary care clinics. Blood was sampled, and dietary intake was estimated using a food frequency questionnaire with 66 food items/food aggregates and questions on the intake of vitamin supplements at gestational weeks 12, 21, and 35, as well as at 12 and 29 weeks after birth. Plasma 25(OH) vitamin D levels were analyzed using liquid chromatography tandem-mass spectrometry. At least one-third of the women had 25(OH) vitamin D levels <50 nmol/L on at least one sampling occasion. Plasma levels increased slightly over the gestation period and peaked in late pregnancy. The levels reverted to the baseline levels after birth. Multivariate analysis showed that gestational and postpartum week, season, dietary intake of vitamin D, and vitamin supplementation were significantly related to plasma levels. There was also an influence of season on the longitudinal concentration patterns. In conclusion, more than one-third of the women studied had low 25(OH) vitamin D levels, and gestational and postpartum week was related to 25(OH) vitamin D levels after adjustment for season and vitamin D intake. |
format |
Article in Journal/Newspaper |
author |
Lundqvist, Anette Sandström, Herbert Stenlund, Hans Johansson, Ingegerd Hultdin, Johan |
author_facet |
Lundqvist, Anette Sandström, Herbert Stenlund, Hans Johansson, Ingegerd Hultdin, Johan |
author_sort |
Lundqvist, Anette |
title |
Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum |
title_short |
Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum |
title_full |
Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum |
title_fullStr |
Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum |
title_full_unstemmed |
Vitamin D Status during Pregnancy : a Longitudinal Study in Swedish Women from Early Pregnancy to Seven Months Postpartum |
title_sort |
vitamin d status during pregnancy : a longitudinal study in swedish women from early pregnancy to seven months postpartum |
publisher |
Umeå universitet, Allmänmedicin |
publishDate |
2016 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117426 https://doi.org/10.1371/journal.pone.0150385 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
PLOS ONE, 2016, 11:3, orcid:0000-0003-1730-699x http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117426 doi:10.1371/journal.pone.0150385 ISI:000371735200077 Scopus 2-s2.0-84961285093 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0150385 |
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PLOS ONE |
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11 |
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3 |
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e0150385 |
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1779318198807560192 |