Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the...
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Umeå universitet, Näringsforskning
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ftumeauniv:oai:DiVA.org:umu-111478 2023-10-09T21:54:35+02:00 Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study Clendenen, Tess V. Ge, Wenzhen Koenig, Karen L. Axelsson, Tomas Liu, Mengling Afanasyeva, Yelena Andersson, Anne Arslan, Alan A. Chen, Yu Hallmans, Göran Lenner, Per Kirchhoff, Tomas Lundin, Eva Shore, Roy E. Sund, Malin Zeleniuch-Jacquotte, Anne 2015 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111478 https://doi.org/10.1371/journal.pone.0140478 eng eng Umeå universitet, Näringsforskning Umeå universitet, Patologi PLOS one PLOS ONE, 2015, 10:10, orcid:0000-0001-9581-3845 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111478 doi:10.1371/journal.pone.0140478 PMID 26488576 ISI:000363248400054 Scopus 2-s2.0-84949494365 info:eu-repo/semantics/openAccess Cancer and Oncology Cancer och onkologi Cell and Molecular Biology Cell- och molekylärbiologi Article in journal info:eu-repo/semantics/article text 2015 ftumeauniv https://doi.org/10.1371/journal.pone.0140478 2023-09-22T13:58:01Z Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH) D concentration in GWAS were also associated with plasma 25(OH) D in our study (p-trend < 0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH) D with breast cancer risk, do not support an association between vitamin D and breast cancer risk. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) PLOS ONE 10 10 e0140478 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cancer and Oncology Cancer och onkologi Cell and Molecular Biology Cell- och molekylärbiologi |
spellingShingle |
Cancer and Oncology Cancer och onkologi Cell and Molecular Biology Cell- och molekylärbiologi Clendenen, Tess V. Ge, Wenzhen Koenig, Karen L. Axelsson, Tomas Liu, Mengling Afanasyeva, Yelena Andersson, Anne Arslan, Alan A. Chen, Yu Hallmans, Göran Lenner, Per Kirchhoff, Tomas Lundin, Eva Shore, Roy E. Sund, Malin Zeleniuch-Jacquotte, Anne Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study |
topic_facet |
Cancer and Oncology Cancer och onkologi Cell and Molecular Biology Cell- och molekylärbiologi |
description |
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH) D concentration in GWAS were also associated with plasma 25(OH) D in our study (p-trend < 0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH) D with breast cancer risk, do not support an association between vitamin D and breast cancer risk. |
format |
Article in Journal/Newspaper |
author |
Clendenen, Tess V. Ge, Wenzhen Koenig, Karen L. Axelsson, Tomas Liu, Mengling Afanasyeva, Yelena Andersson, Anne Arslan, Alan A. Chen, Yu Hallmans, Göran Lenner, Per Kirchhoff, Tomas Lundin, Eva Shore, Roy E. Sund, Malin Zeleniuch-Jacquotte, Anne |
author_facet |
Clendenen, Tess V. Ge, Wenzhen Koenig, Karen L. Axelsson, Tomas Liu, Mengling Afanasyeva, Yelena Andersson, Anne Arslan, Alan A. Chen, Yu Hallmans, Göran Lenner, Per Kirchhoff, Tomas Lundin, Eva Shore, Roy E. Sund, Malin Zeleniuch-Jacquotte, Anne |
author_sort |
Clendenen, Tess V. |
title |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study |
title_short |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study |
title_full |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study |
title_fullStr |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study |
title_full_unstemmed |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study |
title_sort |
genetic polymorphisms in vitamin d metabolism and signaling genes and risk of breast cancer : a nested case-control study |
publisher |
Umeå universitet, Näringsforskning |
publishDate |
2015 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111478 https://doi.org/10.1371/journal.pone.0140478 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
PLOS ONE, 2015, 10:10, orcid:0000-0001-9581-3845 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111478 doi:10.1371/journal.pone.0140478 PMID 26488576 ISI:000363248400054 Scopus 2-s2.0-84949494365 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0140478 |
container_title |
PLOS ONE |
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10 |
container_issue |
10 |
container_start_page |
e0140478 |
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1779318204282175488 |