Season and region as risk factors for celiac disease : a key to the aetiology?
Background: Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several env...
Published in: | Archives of Disease in Childhood |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Umeå universitet, Epidemiologi och global hälsa
2016
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110045 https://doi.org/10.1136/archdischild-2015-310122 |
id |
ftumeauniv:oai:DiVA.org:umu-110045 |
---|---|
record_format |
openpolar |
spelling |
ftumeauniv:oai:DiVA.org:umu-110045 2023-10-09T21:54:36+02:00 Season and region as risk factors for celiac disease : a key to the aetiology? Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof 2016 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110045 https://doi.org/10.1136/archdischild-2015-310122 eng eng Umeå universitet, Epidemiologi och global hälsa Umeå universitet, Institutionen för kostvetenskap Umeå universitet, Pediatrik olof.sandstrom@pediatri.umu.se Archives of Disease in Childhood, 0003-9888, 2016, s. 1114-1118 orcid:0000-0001-5471-9043 orcid:0000-0002-3731-6565 orcid:0000-0001-8944-2558 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110045 doi:10.1136/archdischild-2015-310122 PMID 27528621 ISI:000388822900011 Scopus 2-s2.0-84983507796 info:eu-repo/semantics/openAccess Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2016 ftumeauniv https://doi.org/10.1136/archdischild-2015-310122 2023-09-22T13:57:28Z Background: Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several environmental factors are considered. Methods: A nationwide prospective cohort longitudinal study was conducted consisting of 1 912 204 children aged 0–14.9 years born in Sweden from 1991 to 2009. A total of 6569 children were diagnosed with biopsy-verified CD from 47 paediatric departments. Using Cox regression, we examined the association between CD diagnosis and season of birth, region of birth and year of birth. Results: Overall, CD risk was higher for children born during spring, summer and autumn as compared with children born during winter: adjusted HR for spring 1.08 (95% CI 1.01 to 1.16), summer 1.10 (95% CI 1.03 to 1.18) and autumn 1.10 (95% CI 1.02 to 1.18). Increased CD risk was highest if born in the south, followed by central Sweden when compared with children born in northern Sweden. Children diagnosed at <2 years had an increased CD risk if born in spring while those diagnosed at 2–14.9 years the risk was increased for summer and autumn births. The birth cohort of 1991–1996 had increased CD risk if born during spring, for the 1997–2002 birth cohort the risk increased for summer and autumn births, while for the birth cohort of 2003–2009 the risk was increased if born during autumn. Conclusions: Season of birth and region of birth are independently and jointly associated with increased risk of developing CD during the first 15 years of life. Seasonal variation in infectious load is the likely explanation. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Archives of Disease in Childhood 101 12 1114 1118 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof Season and region as risk factors for celiac disease : a key to the aetiology? |
topic_facet |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Background: Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several environmental factors are considered. Methods: A nationwide prospective cohort longitudinal study was conducted consisting of 1 912 204 children aged 0–14.9 years born in Sweden from 1991 to 2009. A total of 6569 children were diagnosed with biopsy-verified CD from 47 paediatric departments. Using Cox regression, we examined the association between CD diagnosis and season of birth, region of birth and year of birth. Results: Overall, CD risk was higher for children born during spring, summer and autumn as compared with children born during winter: adjusted HR for spring 1.08 (95% CI 1.01 to 1.16), summer 1.10 (95% CI 1.03 to 1.18) and autumn 1.10 (95% CI 1.02 to 1.18). Increased CD risk was highest if born in the south, followed by central Sweden when compared with children born in northern Sweden. Children diagnosed at <2 years had an increased CD risk if born in spring while those diagnosed at 2–14.9 years the risk was increased for summer and autumn births. The birth cohort of 1991–1996 had increased CD risk if born during spring, for the 1997–2002 birth cohort the risk increased for summer and autumn births, while for the birth cohort of 2003–2009 the risk was increased if born during autumn. Conclusions: Season of birth and region of birth are independently and jointly associated with increased risk of developing CD during the first 15 years of life. Seasonal variation in infectious load is the likely explanation. |
format |
Article in Journal/Newspaper |
author |
Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof |
author_facet |
Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof |
author_sort |
Namatovu, Fredinah |
title |
Season and region as risk factors for celiac disease : a key to the aetiology? |
title_short |
Season and region as risk factors for celiac disease : a key to the aetiology? |
title_full |
Season and region as risk factors for celiac disease : a key to the aetiology? |
title_fullStr |
Season and region as risk factors for celiac disease : a key to the aetiology? |
title_full_unstemmed |
Season and region as risk factors for celiac disease : a key to the aetiology? |
title_sort |
season and region as risk factors for celiac disease : a key to the aetiology? |
publisher |
Umeå universitet, Epidemiologi och global hälsa |
publishDate |
2016 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110045 https://doi.org/10.1136/archdischild-2015-310122 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Archives of Disease in Childhood, 0003-9888, 2016, s. 1114-1118 orcid:0000-0001-5471-9043 orcid:0000-0002-3731-6565 orcid:0000-0001-8944-2558 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110045 doi:10.1136/archdischild-2015-310122 PMID 27528621 ISI:000388822900011 Scopus 2-s2.0-84983507796 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/archdischild-2015-310122 |
container_title |
Archives of Disease in Childhood |
container_volume |
101 |
container_issue |
12 |
container_start_page |
1114 |
op_container_end_page |
1118 |
_version_ |
1779318251576098816 |