Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample
Background: The Global Lung Function Initiative 2012 (GLI) reference values are currently endorsed by several respiratory societies but evaluations of applicability for adults resident in European countries are lacking. The aim of this study was to evaluate if the GLI reference values are appropriat...
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Umeå universitet, Yrkes- och miljömedicin
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ftumeauniv:oai:DiVA.org:umu-103744 2024-02-11T10:07:11+01:00 Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample Backman, Helena Lindberg, Anne Sovijarvi, Anssi Larsson, Kjell Lundbäck, Bo Rönmark, Eva 2015 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103744 https://doi.org/10.1186/s12890-015-0022-2 eng eng Umeå universitet, Yrkes- och miljömedicin Umeå universitet, Medicin BMC Pulmonary Medicine, 2015, 15, http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103744 doi:10.1186/s12890-015-0022-2 PMID 25887050 ISI:000353765400002 Scopus 2-s2.0-84928601872 info:eu-repo/semantics/openAccess Lung function Spirometry Reference values Z-score Lower Limit of Normal Respiratory Medicine and Allergy Lungmedicin och allergi Article in journal info:eu-repo/semantics/article text 2015 ftumeauniv https://doi.org/10.1186/s12890-015-0022-2 2024-01-17T23:36:34Z Background: The Global Lung Function Initiative 2012 (GLI) reference values are currently endorsed by several respiratory societies but evaluations of applicability for adults resident in European countries are lacking. The aim of this study was to evaluate if the GLI reference values are appropriate for an adult Caucasian Swedish population. Methods: During 2008-2013, clinical examinations including spirometry were performed on general population samples in northern Sweden, in which 501 healthy Caucasian non-smokers were identified. Predicted GLI reference values and Z-scores were calculated for each healthy non-smoking subject and the distributions and mean values for FEV1, FVC and the FEV1/FVC ratio were examined. The prevalence of airway obstruction among these healthy non-smokers was calculated based on the Lower Limit of normal (LLN) criterion (lower fifth percentile) for the FEV1/FVC ratio. Thus, by definition, a prevalence of 5% was expected. Results: The Z-scores for FEV1, FVC and FEV1/FVC were reasonably, although not perfectly, normally distributed, but not centred on zero. Both predicted FEV1 and, in particular, FVC were lower compared to the observed values in the sample. The deviations were greater among women compared to men. The prevalence of airway obstruction based on the LLN criterion for the FEV1/FVC ratio was 9.4% among women and 2.7% among men. Conclusions: The use of the GLI reference values may produce biased prevalence estimates of airway obstruction in Sweden, especially among women. These results demonstrate the importance of validating the GLI reference values in different countries. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) BMC Pulmonary Medicine 15 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Lung function Spirometry Reference values Z-score Lower Limit of Normal Respiratory Medicine and Allergy Lungmedicin och allergi |
spellingShingle |
Lung function Spirometry Reference values Z-score Lower Limit of Normal Respiratory Medicine and Allergy Lungmedicin och allergi Backman, Helena Lindberg, Anne Sovijarvi, Anssi Larsson, Kjell Lundbäck, Bo Rönmark, Eva Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample |
topic_facet |
Lung function Spirometry Reference values Z-score Lower Limit of Normal Respiratory Medicine and Allergy Lungmedicin och allergi |
description |
Background: The Global Lung Function Initiative 2012 (GLI) reference values are currently endorsed by several respiratory societies but evaluations of applicability for adults resident in European countries are lacking. The aim of this study was to evaluate if the GLI reference values are appropriate for an adult Caucasian Swedish population. Methods: During 2008-2013, clinical examinations including spirometry were performed on general population samples in northern Sweden, in which 501 healthy Caucasian non-smokers were identified. Predicted GLI reference values and Z-scores were calculated for each healthy non-smoking subject and the distributions and mean values for FEV1, FVC and the FEV1/FVC ratio were examined. The prevalence of airway obstruction among these healthy non-smokers was calculated based on the Lower Limit of normal (LLN) criterion (lower fifth percentile) for the FEV1/FVC ratio. Thus, by definition, a prevalence of 5% was expected. Results: The Z-scores for FEV1, FVC and FEV1/FVC were reasonably, although not perfectly, normally distributed, but not centred on zero. Both predicted FEV1 and, in particular, FVC were lower compared to the observed values in the sample. The deviations were greater among women compared to men. The prevalence of airway obstruction based on the LLN criterion for the FEV1/FVC ratio was 9.4% among women and 2.7% among men. Conclusions: The use of the GLI reference values may produce biased prevalence estimates of airway obstruction in Sweden, especially among women. These results demonstrate the importance of validating the GLI reference values in different countries. |
format |
Article in Journal/Newspaper |
author |
Backman, Helena Lindberg, Anne Sovijarvi, Anssi Larsson, Kjell Lundbäck, Bo Rönmark, Eva |
author_facet |
Backman, Helena Lindberg, Anne Sovijarvi, Anssi Larsson, Kjell Lundbäck, Bo Rönmark, Eva |
author_sort |
Backman, Helena |
title |
Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample |
title_short |
Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample |
title_full |
Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample |
title_fullStr |
Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample |
title_full_unstemmed |
Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample |
title_sort |
evaluation of the global lung function initiative 2012 reference values for spirometry in a swedish population sample |
publisher |
Umeå universitet, Yrkes- och miljömedicin |
publishDate |
2015 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103744 https://doi.org/10.1186/s12890-015-0022-2 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
BMC Pulmonary Medicine, 2015, 15, http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103744 doi:10.1186/s12890-015-0022-2 PMID 25887050 ISI:000353765400002 Scopus 2-s2.0-84928601872 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s12890-015-0022-2 |
container_title |
BMC Pulmonary Medicine |
container_volume |
15 |
container_issue |
1 |
_version_ |
1790605348821794816 |