Presence of immunological markers preceding the onset of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease with an unknown aetiology characterized by joint destruction. Both genetic and environmental factors contribute to the disease development with HLA-DRB1* alleles and smoking identified as most important. The disease is characterized by the...
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Umeå universitet, Reumatologi
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ftumeauniv:oai:DiVA.org:umu-102589 2023-10-09T21:54:38+02:00 Presence of immunological markers preceding the onset of rheumatoid arthritis Förekomst av immunologiska markörer som föregår debuten av reumatoid artrit Brink, Mikael 2015 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102589 eng eng Umeå universitet, Reumatologi Umeå : Umeå Universitet Umeå University medical dissertations, 0346-6612 1714 orcid:0000-0001-7675-3488 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102589 urn:isbn:978-91-7601-259-8 info:eu-repo/semantics/openAccess autoantibodies rheumatoid arthritis anti citrullinated protein antibodies pre-symptomatic individual Rheumatology and Autoimmunity Reumatologi och inflammation Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2015 ftumeauniv 2023-09-22T13:53:30Z Rheumatoid arthritis (RA) is a chronic inflammatory disease with an unknown aetiology characterized by joint destruction. Both genetic and environmental factors contribute to the disease development with HLA-DRB1* alleles and smoking identified as most important. The disease is characterized by the presence of autoantibodies, originally by rheumatoid factor (RF) and more recently by anti citrullinated protein/peptide antibodies (ACPA) and antibodies against carbamylated peptides (CarP). These autoantibodies are present, not only after the onset of disease, but also prior to the onset of symptoms. The development of RA is a gradual process lasting several years before the onset of any joint symptom, but when and if there is a temporal difference in the development both between and within the different antibody systems is currently unknown. B-cells produce the antibodies, and a subset of B-cells, i.e., B-regulatory (Breg) cells, produces interleukin-10, and thus have the ability to down-regulate pro-inflammatory cytokines. Whether the Breg cells are involved in the pathogenesis of RA is, as yet, unknown. The aim of this thesis was to increase knowledge of the pathophysiological processes in the development of RA through identification of factors involved. The analyses involved detection of autoantibodies to post-translationally modified peptides/proteins in addition to RF isotypes, cell surface markers on immune cells in asymptomatic individuals, who have an increased risk of developing RA. In a co-analysis of the registers of patients with RA attending the Department of Rheumatology, with the registers from population based screening programmes within the Biobank of Northern Sweden, blood samples collected from individuals prior to the onset of symptoms were identified, as were those from population control subjects. A cohort of pre-symptomatic individuals also donated samples at the time of receiving a diagnosis of RA. First-degree relatives (FDR) of patients with RA were also identified and included for ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
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Umeå University: Publications (DiVA) |
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ftumeauniv |
language |
English |
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autoantibodies rheumatoid arthritis anti citrullinated protein antibodies pre-symptomatic individual Rheumatology and Autoimmunity Reumatologi och inflammation |
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autoantibodies rheumatoid arthritis anti citrullinated protein antibodies pre-symptomatic individual Rheumatology and Autoimmunity Reumatologi och inflammation Brink, Mikael Presence of immunological markers preceding the onset of rheumatoid arthritis |
topic_facet |
autoantibodies rheumatoid arthritis anti citrullinated protein antibodies pre-symptomatic individual Rheumatology and Autoimmunity Reumatologi och inflammation |
description |
Rheumatoid arthritis (RA) is a chronic inflammatory disease with an unknown aetiology characterized by joint destruction. Both genetic and environmental factors contribute to the disease development with HLA-DRB1* alleles and smoking identified as most important. The disease is characterized by the presence of autoantibodies, originally by rheumatoid factor (RF) and more recently by anti citrullinated protein/peptide antibodies (ACPA) and antibodies against carbamylated peptides (CarP). These autoantibodies are present, not only after the onset of disease, but also prior to the onset of symptoms. The development of RA is a gradual process lasting several years before the onset of any joint symptom, but when and if there is a temporal difference in the development both between and within the different antibody systems is currently unknown. B-cells produce the antibodies, and a subset of B-cells, i.e., B-regulatory (Breg) cells, produces interleukin-10, and thus have the ability to down-regulate pro-inflammatory cytokines. Whether the Breg cells are involved in the pathogenesis of RA is, as yet, unknown. The aim of this thesis was to increase knowledge of the pathophysiological processes in the development of RA through identification of factors involved. The analyses involved detection of autoantibodies to post-translationally modified peptides/proteins in addition to RF isotypes, cell surface markers on immune cells in asymptomatic individuals, who have an increased risk of developing RA. In a co-analysis of the registers of patients with RA attending the Department of Rheumatology, with the registers from population based screening programmes within the Biobank of Northern Sweden, blood samples collected from individuals prior to the onset of symptoms were identified, as were those from population control subjects. A cohort of pre-symptomatic individuals also donated samples at the time of receiving a diagnosis of RA. First-degree relatives (FDR) of patients with RA were also identified and included for ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Brink, Mikael |
author_facet |
Brink, Mikael |
author_sort |
Brink, Mikael |
title |
Presence of immunological markers preceding the onset of rheumatoid arthritis |
title_short |
Presence of immunological markers preceding the onset of rheumatoid arthritis |
title_full |
Presence of immunological markers preceding the onset of rheumatoid arthritis |
title_fullStr |
Presence of immunological markers preceding the onset of rheumatoid arthritis |
title_full_unstemmed |
Presence of immunological markers preceding the onset of rheumatoid arthritis |
title_sort |
presence of immunological markers preceding the onset of rheumatoid arthritis |
publisher |
Umeå universitet, Reumatologi |
publishDate |
2015 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102589 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 1714 orcid:0000-0001-7675-3488 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102589 urn:isbn:978-91-7601-259-8 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318298777747456 |