Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer
Background: The aim of this thesis was to study the relationship of pre-diagnostic circulating concentrations of sex steroid hormones (androgens, estradiol, 17-hydroxyprogesterone, and progesterone), growth factors (insulin-like growth factor-I (IGF-I), placental growth hormone (GH)), sex hormone bi...
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Umeå universitet, Institutionen för medicinsk biovetenskap
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ftumeauniv:oai:DiVA.org:umu-102181 2023-10-09T21:54:38+02:00 Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer Schock, Helena 2015 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102181 eng eng Umeå universitet, Institutionen för medicinsk biovetenskap Umeå : Umeå universitet Umeå University medical dissertations, 0346-6612 1715 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102181 urn:isbn:978-91-7601-273-4 info:eu-repo/semantics/openAccess epithelial ovarian cancer sex steroid hormones IGF-I placental GH AMH pregnancy prospective study Medical Bioscience Medicinsk biovetenskap Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2015 ftumeauniv 2023-09-22T13:48:38Z Background: The aim of this thesis was to study the relationship of pre-diagnostic circulating concentrations of sex steroid hormones (androgens, estradiol, 17-hydroxyprogesterone, and progesterone), growth factors (insulin-like growth factor-I (IGF-I), placental growth hormone (GH)), sex hormone binding globulin (SHBG), and anti-Müllerian hormone (AMH) with risk of epithelial ovarian cancer (EOC) overall, and by tumor invasiveness and histology. A longitudinal study was used to assess patterns of hormonal changes during a single pregnancy, and in two consecutive pregnancies. Materials & Methods: A case-control study was nested within the Finnish Maternity Cohort and the Northern Sweden Maternity Cohort. A total of 1 052 EOC cases were identified through linkages with the cancer registries in both countries. For each case, 2-3 controls were selected. Cases and controls were matched on cohort, age and date at blood draw, as well as for parity at blood draw and at diagnosis (n=2 695). Odds ratios (OR) and corresponding 95% confidence intervals [CI] were estimated using conditional logistic regression. The longitudinal study was based on 71 pregnant Finnish women, who donated blood samples in each trimester of pregnancy. Results: Higher androgen concentrations were associated with an increased risk of overall EOC (e.g., testosterone ORT3 vs. T1: 1.56 [1.30-1.87], ptrend<0.0001), while the risk of endometrioid tumors increased with higher estradiol concentrations (ORT3 vs. T1: 2.76 [1.04-7.33], ptrend=0.03). Higher IGF-I was associated with a non-significant decrease in risk for invasive (ORT3 vs. T1: 0.79 [0.62-1.02], ptrend=0.07) and endometrioid tumors (ORT3 vs. T1: 0.55 [0.28-1.07], ptrend=0.07). The inverse association between IGF-I levels and risk of invasive EOC was stronger in analyses limited to women aged <55 years at diagnosis (ORT3 vs. T1: 0.74 [0.57-0.96], ptrend=0.03). No associations were observed between pre-diagnostic progesterone, SHBG, placental GH, and AMH with EOC risk overall, or by ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
institution |
Open Polar |
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Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
epithelial ovarian cancer sex steroid hormones IGF-I placental GH AMH pregnancy prospective study Medical Bioscience Medicinsk biovetenskap |
spellingShingle |
epithelial ovarian cancer sex steroid hormones IGF-I placental GH AMH pregnancy prospective study Medical Bioscience Medicinsk biovetenskap Schock, Helena Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
topic_facet |
epithelial ovarian cancer sex steroid hormones IGF-I placental GH AMH pregnancy prospective study Medical Bioscience Medicinsk biovetenskap |
description |
Background: The aim of this thesis was to study the relationship of pre-diagnostic circulating concentrations of sex steroid hormones (androgens, estradiol, 17-hydroxyprogesterone, and progesterone), growth factors (insulin-like growth factor-I (IGF-I), placental growth hormone (GH)), sex hormone binding globulin (SHBG), and anti-Müllerian hormone (AMH) with risk of epithelial ovarian cancer (EOC) overall, and by tumor invasiveness and histology. A longitudinal study was used to assess patterns of hormonal changes during a single pregnancy, and in two consecutive pregnancies. Materials & Methods: A case-control study was nested within the Finnish Maternity Cohort and the Northern Sweden Maternity Cohort. A total of 1 052 EOC cases were identified through linkages with the cancer registries in both countries. For each case, 2-3 controls were selected. Cases and controls were matched on cohort, age and date at blood draw, as well as for parity at blood draw and at diagnosis (n=2 695). Odds ratios (OR) and corresponding 95% confidence intervals [CI] were estimated using conditional logistic regression. The longitudinal study was based on 71 pregnant Finnish women, who donated blood samples in each trimester of pregnancy. Results: Higher androgen concentrations were associated with an increased risk of overall EOC (e.g., testosterone ORT3 vs. T1: 1.56 [1.30-1.87], ptrend<0.0001), while the risk of endometrioid tumors increased with higher estradiol concentrations (ORT3 vs. T1: 2.76 [1.04-7.33], ptrend=0.03). Higher IGF-I was associated with a non-significant decrease in risk for invasive (ORT3 vs. T1: 0.79 [0.62-1.02], ptrend=0.07) and endometrioid tumors (ORT3 vs. T1: 0.55 [0.28-1.07], ptrend=0.07). The inverse association between IGF-I levels and risk of invasive EOC was stronger in analyses limited to women aged <55 years at diagnosis (ORT3 vs. T1: 0.74 [0.57-0.96], ptrend=0.03). No associations were observed between pre-diagnostic progesterone, SHBG, placental GH, and AMH with EOC risk overall, or by ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Schock, Helena |
author_facet |
Schock, Helena |
author_sort |
Schock, Helena |
title |
Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
title_short |
Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
title_full |
Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
title_fullStr |
Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
title_full_unstemmed |
Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
title_sort |
hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer |
publisher |
Umeå universitet, Institutionen för medicinsk biovetenskap |
publishDate |
2015 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102181 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 1715 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102181 urn:isbn:978-91-7601-273-4 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318304701153280 |