Aqueous carbonic acid: A readily removable electrolyte for the recovery of [18F]fluoride from anion exchange resins

• Published in: International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
• Main Author: Jewett, Douglas M.
• Other Authors: Division of Internal Medicine, Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, U.S.A.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 1991
• Subjects: Physics; Nuclear Engineering and Radiological Sciences; Science; Engineering; Carbonic acid
• Online Access: https://hdl.handle.net/2027.42/29616; http://www.sciencedirect.com/science/article/B6X3S-47312RW-DM/2/d2ae8d1028a0e93ff6285faf861b1fc1; http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1850718&dopt=citation; https://doi.org/10.1016/0883-2889(91)90148-T

[18F]Fluoride was recovered from [18O]target water in high yield by trapping it on a microcolumn of an anion exchange resin (20 mg Dowex 1 x 8, 400 mesh) and subsequent elution of the column (in the reverse direction) by aqueous carbonic acid at 52 atm. The carbonic acid was removed from the [18F]fluoride solution by brief heating at 85[deg]C, 1 atm. Thus no extraneous electrolyte was introduced by the extraction process. The resulting bicarbonate form of the resin was immediately capable of trapping further [18F]fluoride, permitting a repetitive remote system for recovery of [18O]water. Chloride was substantially retained on the column permitting separation of [18F]fluoride from the former. Peer Reviewed http://deepblue.lib.umich.edu/bitstream/2027.42/29616/1/0000705.pdf