Prion protein genes in caribou from Alaska
Prion protein genes were sequenced in free-ranging Alaska caribou (Rangifer tarandus grantii). Caribou prion alleles are identical or nearly so to those of wapiti, white-tailed deer, and mule deer. Five single-nucleotide polymorphisms were detected with substitutions at residues 2 (V→M), 129 (G≤S),...
Main Authors: | , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2007
|
Subjects: | |
Online Access: | https://research.manchester.ac.uk/en/publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 |
id |
ftumanchesterpub:oai:pure.atira.dk:publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 |
---|---|
record_format |
openpolar |
spelling |
ftumanchesterpub:oai:pure.atira.dk:publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 2024-06-23T07:56:21+00:00 Prion protein genes in caribou from Alaska Happ, George M. Huson, Heather J. Beckmen, Kimberlee B. Kennedy, Lorna J. 2007-04 https://research.manchester.ac.uk/en/publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 eng eng https://research.manchester.ac.uk/en/publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 info:eu-repo/semantics/restrictedAccess Happ , G M , Huson , H J , Beckmen , K B & Kennedy , L J 2007 , ' Prion protein genes in caribou from Alaska ' , Journal of Wildlife Diseases , vol. 43 , no. 2 , pp. 224-228 . Caribou Chronic wasting disease Prion Rangifer tarandus grantil Reindeer Transmissible spongiform encephalopathy article 2007 ftumanchesterpub 2024-06-04T00:21:31Z Prion protein genes were sequenced in free-ranging Alaska caribou (Rangifer tarandus grantii). Caribou prion alleles are identical or nearly so to those of wapiti, white-tailed deer, and mule deer. Five single-nucleotide polymorphisms were detected with substitutions at residues 2 (V→M), 129 (G≤S), 138 (S→N), 146 (N→N), and 169 (V→M). The 138N codon had been previously reported only in prion pseudogenes of other cervids. In caribou, the 138S and 138N alleles are present at frequencies of approximately 0.7 and 0.3, respectively, and they are seen in both homozygotes and heterozygotes of three geographically separated herds, each a component of the continental metapopulation. Genetics seems to permit the spread of chronic wasting disease from middle-latitude deer to high-latitude caribou in North America. © Wildlife Disease Association 2007. Article in Journal/Newspaper Rangifer tarandus Alaska The University of Manchester: Research Explorer |
institution |
Open Polar |
collection |
The University of Manchester: Research Explorer |
op_collection_id |
ftumanchesterpub |
language |
English |
topic |
Caribou Chronic wasting disease Prion Rangifer tarandus grantil Reindeer Transmissible spongiform encephalopathy |
spellingShingle |
Caribou Chronic wasting disease Prion Rangifer tarandus grantil Reindeer Transmissible spongiform encephalopathy Happ, George M. Huson, Heather J. Beckmen, Kimberlee B. Kennedy, Lorna J. Prion protein genes in caribou from Alaska |
topic_facet |
Caribou Chronic wasting disease Prion Rangifer tarandus grantil Reindeer Transmissible spongiform encephalopathy |
description |
Prion protein genes were sequenced in free-ranging Alaska caribou (Rangifer tarandus grantii). Caribou prion alleles are identical or nearly so to those of wapiti, white-tailed deer, and mule deer. Five single-nucleotide polymorphisms were detected with substitutions at residues 2 (V→M), 129 (G≤S), 138 (S→N), 146 (N→N), and 169 (V→M). The 138N codon had been previously reported only in prion pseudogenes of other cervids. In caribou, the 138S and 138N alleles are present at frequencies of approximately 0.7 and 0.3, respectively, and they are seen in both homozygotes and heterozygotes of three geographically separated herds, each a component of the continental metapopulation. Genetics seems to permit the spread of chronic wasting disease from middle-latitude deer to high-latitude caribou in North America. © Wildlife Disease Association 2007. |
format |
Article in Journal/Newspaper |
author |
Happ, George M. Huson, Heather J. Beckmen, Kimberlee B. Kennedy, Lorna J. |
author_facet |
Happ, George M. Huson, Heather J. Beckmen, Kimberlee B. Kennedy, Lorna J. |
author_sort |
Happ, George M. |
title |
Prion protein genes in caribou from Alaska |
title_short |
Prion protein genes in caribou from Alaska |
title_full |
Prion protein genes in caribou from Alaska |
title_fullStr |
Prion protein genes in caribou from Alaska |
title_full_unstemmed |
Prion protein genes in caribou from Alaska |
title_sort |
prion protein genes in caribou from alaska |
publishDate |
2007 |
url |
https://research.manchester.ac.uk/en/publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 |
genre |
Rangifer tarandus Alaska |
genre_facet |
Rangifer tarandus Alaska |
op_source |
Happ , G M , Huson , H J , Beckmen , K B & Kennedy , L J 2007 , ' Prion protein genes in caribou from Alaska ' , Journal of Wildlife Diseases , vol. 43 , no. 2 , pp. 224-228 . |
op_relation |
https://research.manchester.ac.uk/en/publications/f7d2e2bd-3e48-4de3-a490-c99fc5deb5f8 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1802649390495563776 |