Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study
Aims: Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation...
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2008
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Online Access: | https://research.manchester.ac.uk/en/publications/dda88b23-b3d2-4291-9617-bbef7a577ea0 https://doi.org/10.1093/eurheartj/ehn105 |
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ftumanchesterpub:oai:pure.atira.dk:publications/dda88b23-b3d2-4291-9617-bbef7a577ea0 2023-11-12T04:23:14+01:00 Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study Tzoulaki, Ioanna Jarvelin, Marjo Riitta Hartikainen, Anna Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul 2008-04 https://research.manchester.ac.uk/en/publications/dda88b23-b3d2-4291-9617-bbef7a577ea0 https://doi.org/10.1093/eurheartj/ehn105 eng eng info:eu-repo/semantics/closedAccess Tzoulaki , I , Jarvelin , M R , Hartikainen , A L , Leinonen , M , Pouta , A , Paldanius , M , Ruokonen , A , Canoy , D , Sovio , U , Saikku , P & Elliott , P 2008 , ' Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study ' , European Heart Journal , vol. 29 , no. 8 , pp. 1049-1056 . https://doi.org/10.1093/eurheartj/ehn105 Birth weight C-reactive protein Cardiovascular risk factors Life course epidomiology Weight gain article 2008 ftumanchesterpub https://doi.org/10.1093/eurheartj/ehn105 2023-10-30T09:17:33Z Aims: Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. Methods and results: General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Conclusion: Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults. © The Author 2008. Article in Journal/Newspaper Northern Finland The University of Manchester: Research Explorer European Heart Journal 29 8 1049 1056 |
institution |
Open Polar |
collection |
The University of Manchester: Research Explorer |
op_collection_id |
ftumanchesterpub |
language |
English |
topic |
Birth weight C-reactive protein Cardiovascular risk factors Life course epidomiology Weight gain |
spellingShingle |
Birth weight C-reactive protein Cardiovascular risk factors Life course epidomiology Weight gain Tzoulaki, Ioanna Jarvelin, Marjo Riitta Hartikainen, Anna Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study |
topic_facet |
Birth weight C-reactive protein Cardiovascular risk factors Life course epidomiology Weight gain |
description |
Aims: Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. Methods and results: General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Conclusion: Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults. © The Author 2008. |
format |
Article in Journal/Newspaper |
author |
Tzoulaki, Ioanna Jarvelin, Marjo Riitta Hartikainen, Anna Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul |
author_facet |
Tzoulaki, Ioanna Jarvelin, Marjo Riitta Hartikainen, Anna Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul |
author_sort |
Tzoulaki, Ioanna |
title |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study |
title_short |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study |
title_full |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study |
title_fullStr |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study |
title_full_unstemmed |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study |
title_sort |
size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern finland 1966 birth cohort study |
publishDate |
2008 |
url |
https://research.manchester.ac.uk/en/publications/dda88b23-b3d2-4291-9617-bbef7a577ea0 https://doi.org/10.1093/eurheartj/ehn105 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Tzoulaki , I , Jarvelin , M R , Hartikainen , A L , Leinonen , M , Pouta , A , Paldanius , M , Ruokonen , A , Canoy , D , Sovio , U , Saikku , P & Elliott , P 2008 , ' Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 birth cohort study ' , European Heart Journal , vol. 29 , no. 8 , pp. 1049-1056 . https://doi.org/10.1093/eurheartj/ehn105 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1093/eurheartj/ehn105 |
container_title |
European Heart Journal |
container_volume |
29 |
container_issue |
8 |
container_start_page |
1049 |
op_container_end_page |
1056 |
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1782338077882056704 |