Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle
Low-grade, systemic inflammation is related to increased risk of cardiovascular disease in adults. The proinflammatory state tracks from adolescence to adulthood. Identifying correlates of inflammation in adolescents could provide opportunities to prevent cardiovascular disease in adulthood. However...
Published in: | American Journal of Epidemiology |
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Online Access: | https://research.manchester.ac.uk/en/publications/a230ff17-4a74-4d88-a93f-dd999b96b34c https://doi.org/10.1093/aje/kwp320 |
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ftumanchesterpub:oai:pure.atira.dk:publications/a230ff17-4a74-4d88-a93f-dd999b96b34c 2023-11-12T04:23:15+01:00 Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle Pirkola, Jatta Vääräsmäki, Marja Ala-Korpela, Mika Bloigu, Aini Canoy, Dexter Hartikainen, Anna Liisa Leinonen, Maija Miettola, Satu Paldanius, Mika Tammelin, Tuija H. Järvelin, Marjo Riitta Pouta, Anneli 2010-01 https://research.manchester.ac.uk/en/publications/a230ff17-4a74-4d88-a93f-dd999b96b34c https://doi.org/10.1093/aje/kwp320 eng eng info:eu-repo/semantics/closedAccess Pirkola , J , Vääräsmäki , M , Ala-Korpela , M , Bloigu , A , Canoy , D , Hartikainen , A L , Leinonen , M , Miettola , S , Paldanius , M , Tammelin , T H , Järvelin , M R & Pouta , A 2010 , ' Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle ' , American Journal of Epidemiology , vol. 171 , no. 1 , pp. 72-82 . https://doi.org/10.1093/aje/kwp320 C-reactive protein Cardiovascular diseases Cohort studies Contraceptives oral Gestational age Leukocyte count Obesity Smoking article 2010 ftumanchesterpub https://doi.org/10.1093/aje/kwp320 2023-10-30T09:13:44Z Low-grade, systemic inflammation is related to increased risk of cardiovascular disease in adults. The proinflammatory state tracks from adolescence to adulthood. Identifying correlates of inflammation in adolescents could provide opportunities to prevent cardiovascular disease in adulthood. However, population-based data on correlates of inflammation in adolescence are limited. Therefore, the authors studied the associations of early-life factors, gender, and lifestyle with inflammation (measured by high-sensitivity C-reactive protein and leukocyte count) at age 16 years (2001-2002) in the prospective, population-based Northern Finland Birth Cohort 1986 Study (n = 5,240). In females, being born small for gestational age and current use of oral contraceptives were associated with the proinflammatory state. The association of birth size with inflammation was not observed in males. In logistic regression analyses, oral contraceptive use (odds ratio (OR)=2.83), abdominal obesity (OR=5.17), and smoking (OR=2.72) were associated with elevation of both inflammation markers in females; abdominal obesity (OR=5.72) and smoking (OR=2.02) were associated in males. Thus, females appear more susceptible to the adverse effects of being born small for gestational age than males. Given the widespread use of oral contraceptives and the potential pathophysiologic consequences of the proinflammatory state, the association of oral contraceptive use with inflammation in adolescence may have public health implications. Article in Journal/Newspaper Northern Finland The University of Manchester: Research Explorer American Journal of Epidemiology 171 1 72 82 |
institution |
Open Polar |
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The University of Manchester: Research Explorer |
op_collection_id |
ftumanchesterpub |
language |
English |
topic |
C-reactive protein Cardiovascular diseases Cohort studies Contraceptives oral Gestational age Leukocyte count Obesity Smoking |
spellingShingle |
C-reactive protein Cardiovascular diseases Cohort studies Contraceptives oral Gestational age Leukocyte count Obesity Smoking Pirkola, Jatta Vääräsmäki, Marja Ala-Korpela, Mika Bloigu, Aini Canoy, Dexter Hartikainen, Anna Liisa Leinonen, Maija Miettola, Satu Paldanius, Mika Tammelin, Tuija H. Järvelin, Marjo Riitta Pouta, Anneli Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle |
topic_facet |
C-reactive protein Cardiovascular diseases Cohort studies Contraceptives oral Gestational age Leukocyte count Obesity Smoking |
description |
Low-grade, systemic inflammation is related to increased risk of cardiovascular disease in adults. The proinflammatory state tracks from adolescence to adulthood. Identifying correlates of inflammation in adolescents could provide opportunities to prevent cardiovascular disease in adulthood. However, population-based data on correlates of inflammation in adolescence are limited. Therefore, the authors studied the associations of early-life factors, gender, and lifestyle with inflammation (measured by high-sensitivity C-reactive protein and leukocyte count) at age 16 years (2001-2002) in the prospective, population-based Northern Finland Birth Cohort 1986 Study (n = 5,240). In females, being born small for gestational age and current use of oral contraceptives were associated with the proinflammatory state. The association of birth size with inflammation was not observed in males. In logistic regression analyses, oral contraceptive use (odds ratio (OR)=2.83), abdominal obesity (OR=5.17), and smoking (OR=2.72) were associated with elevation of both inflammation markers in females; abdominal obesity (OR=5.72) and smoking (OR=2.02) were associated in males. Thus, females appear more susceptible to the adverse effects of being born small for gestational age than males. Given the widespread use of oral contraceptives and the potential pathophysiologic consequences of the proinflammatory state, the association of oral contraceptive use with inflammation in adolescence may have public health implications. |
format |
Article in Journal/Newspaper |
author |
Pirkola, Jatta Vääräsmäki, Marja Ala-Korpela, Mika Bloigu, Aini Canoy, Dexter Hartikainen, Anna Liisa Leinonen, Maija Miettola, Satu Paldanius, Mika Tammelin, Tuija H. Järvelin, Marjo Riitta Pouta, Anneli |
author_facet |
Pirkola, Jatta Vääräsmäki, Marja Ala-Korpela, Mika Bloigu, Aini Canoy, Dexter Hartikainen, Anna Liisa Leinonen, Maija Miettola, Satu Paldanius, Mika Tammelin, Tuija H. Järvelin, Marjo Riitta Pouta, Anneli |
author_sort |
Pirkola, Jatta |
title |
Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle |
title_short |
Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle |
title_full |
Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle |
title_fullStr |
Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle |
title_full_unstemmed |
Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle |
title_sort |
low-grade, systemic inflammation in adolescents: association with early-life factors, gender, and lifestyle |
publishDate |
2010 |
url |
https://research.manchester.ac.uk/en/publications/a230ff17-4a74-4d88-a93f-dd999b96b34c https://doi.org/10.1093/aje/kwp320 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Pirkola , J , Vääräsmäki , M , Ala-Korpela , M , Bloigu , A , Canoy , D , Hartikainen , A L , Leinonen , M , Miettola , S , Paldanius , M , Tammelin , T H , Järvelin , M R & Pouta , A 2010 , ' Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle ' , American Journal of Epidemiology , vol. 171 , no. 1 , pp. 72-82 . https://doi.org/10.1093/aje/kwp320 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1093/aje/kwp320 |
container_title |
American Journal of Epidemiology |
container_volume |
171 |
container_issue |
1 |
container_start_page |
72 |
op_container_end_page |
82 |
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1782338084895981568 |