Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears.
Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyper-lipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show...
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Online Access: | https://research.manchester.ac.uk/en/publications/8be785a6-c45f-454c-803f-56efcd1c03c9 https://doi.org/10.1016/j.cell.2014.03.054 |
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ftumanchesterpub:oai:pure.atira.dk:publications/8be785a6-c45f-454c-803f-56efcd1c03c9 2023-11-12T04:11:54+01:00 Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. Liu, Shiping Lorenzen, Eline D Fumagalli, Matteo Li, Bo Harris, Kelley Xiong, Zijun Zhou, Long Korneliussen, Thorfinn Sand Somel, Mehmet Babbitt, Courtney Wray, Greg Li, Jianwen He, Weiming Wang, Zhuo Fu, Wenjing Xiang, Xueyan Morgan, Claire C Doherty, Aoife O'Connell, Mary J Mcinerney, James Born, Erik W Dalén, Love Dietz, Rune Orlando, Ludovic Sonne, Christian Zhang, Guojie Nielsen, Rasmus Willerslev, Eske Wang, Jun 2014-05-08 https://research.manchester.ac.uk/en/publications/8be785a6-c45f-454c-803f-56efcd1c03c9 https://doi.org/10.1016/j.cell.2014.03.054 eng eng info:eu-repo/semantics/closedAccess Liu , S , Lorenzen , E D , Fumagalli , M , Li , B , Harris , K , Xiong , Z , Zhou , L , Korneliussen , T S , Somel , M , Babbitt , C , Wray , G , Li , J , He , W , Wang , Z , Fu , W , Xiang , X , Morgan , C C , Doherty , A , O'Connell , M J , Mcinerney , J , Born , E W , Dalén , L , Dietz , R , Orlando , L , Sonne , C , Zhang , G , Nielsen , R , Willerslev , E & Wang , J 2014 , ' Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. ' , Cell , vol. 157 , no. 4 . https://doi.org/10.1016/j.cell.2014.03.054 article 2014 ftumanchesterpub https://doi.org/10.1016/j.cell.2014.03.054 2023-10-30T09:14:44Z Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyper-lipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans. Article in Journal/Newspaper Arctic brown bear The University of Manchester: Research Explorer Arctic Cell 157 4 785 794 |
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Open Polar |
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The University of Manchester: Research Explorer |
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ftumanchesterpub |
language |
English |
description |
Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyper-lipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans. |
format |
Article in Journal/Newspaper |
author |
Liu, Shiping Lorenzen, Eline D Fumagalli, Matteo Li, Bo Harris, Kelley Xiong, Zijun Zhou, Long Korneliussen, Thorfinn Sand Somel, Mehmet Babbitt, Courtney Wray, Greg Li, Jianwen He, Weiming Wang, Zhuo Fu, Wenjing Xiang, Xueyan Morgan, Claire C Doherty, Aoife O'Connell, Mary J Mcinerney, James Born, Erik W Dalén, Love Dietz, Rune Orlando, Ludovic Sonne, Christian Zhang, Guojie Nielsen, Rasmus Willerslev, Eske Wang, Jun |
spellingShingle |
Liu, Shiping Lorenzen, Eline D Fumagalli, Matteo Li, Bo Harris, Kelley Xiong, Zijun Zhou, Long Korneliussen, Thorfinn Sand Somel, Mehmet Babbitt, Courtney Wray, Greg Li, Jianwen He, Weiming Wang, Zhuo Fu, Wenjing Xiang, Xueyan Morgan, Claire C Doherty, Aoife O'Connell, Mary J Mcinerney, James Born, Erik W Dalén, Love Dietz, Rune Orlando, Ludovic Sonne, Christian Zhang, Guojie Nielsen, Rasmus Willerslev, Eske Wang, Jun Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
author_facet |
Liu, Shiping Lorenzen, Eline D Fumagalli, Matteo Li, Bo Harris, Kelley Xiong, Zijun Zhou, Long Korneliussen, Thorfinn Sand Somel, Mehmet Babbitt, Courtney Wray, Greg Li, Jianwen He, Weiming Wang, Zhuo Fu, Wenjing Xiang, Xueyan Morgan, Claire C Doherty, Aoife O'Connell, Mary J Mcinerney, James Born, Erik W Dalén, Love Dietz, Rune Orlando, Ludovic Sonne, Christian Zhang, Guojie Nielsen, Rasmus Willerslev, Eske Wang, Jun |
author_sort |
Liu, Shiping |
title |
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
title_short |
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
title_full |
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
title_fullStr |
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
title_full_unstemmed |
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
title_sort |
population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. |
publishDate |
2014 |
url |
https://research.manchester.ac.uk/en/publications/8be785a6-c45f-454c-803f-56efcd1c03c9 https://doi.org/10.1016/j.cell.2014.03.054 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic brown bear |
genre_facet |
Arctic brown bear |
op_source |
Liu , S , Lorenzen , E D , Fumagalli , M , Li , B , Harris , K , Xiong , Z , Zhou , L , Korneliussen , T S , Somel , M , Babbitt , C , Wray , G , Li , J , He , W , Wang , Z , Fu , W , Xiang , X , Morgan , C C , Doherty , A , O'Connell , M J , Mcinerney , J , Born , E W , Dalén , L , Dietz , R , Orlando , L , Sonne , C , Zhang , G , Nielsen , R , Willerslev , E & Wang , J 2014 , ' Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. ' , Cell , vol. 157 , no. 4 . https://doi.org/10.1016/j.cell.2014.03.054 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.cell.2014.03.054 |
container_title |
Cell |
container_volume |
157 |
container_issue |
4 |
container_start_page |
785 |
op_container_end_page |
794 |
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1782330763702697984 |