3-methyl-phenanthrene (3-MP) disrupts the electrical and contractile activity of the heart of the polar fish, navaga cod (Eleginus nawaga)

• Published in: Chemosphere
• Main Authors: Filatova, Tatiana s., Kuzmin, Vladislav s., Dzhumaniiazova, Irina, Pustovit, Oksana b., Abramochkin, Denis v., Shiels, Holly a.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2024
• Subjects: Arctic; cardiac toxicity; alkylated polycyclic aromatic hydrocarbons; INa; ICa; IKr; erg-channel; depolarization; repolarization; Navaga
• Online Access: https://research.manchester.ac.uk/en/publications/8af9194f-8acb-48e0-b781-bba246798ed7; https://doi.org/10.1016/j.chemosphere.2024.142089; https://pure.manchester.ac.uk/ws/files/300317328/3MP_Manuscript_noname_revision1_CLEAN_COPY.docx

Alkylated polycyclic aromatic hydrocarbons are abundant in crude oil and are enriched during petroleum refinement but knowledge of their cardiotoxicity remains limited. Polycyclic aromatic hydrocarbons (PAHs) are considered the main hazardous components in crude oil and the tricyclic PAH phenanthren...