Fishing for Keys to Longevity in the Heart of the Greenland Shark
The Greenland shark (Somniosus microcephalus) is the longest living vertebrate on the planet with a life span of at least 272 years. This extreme longevity is particularly interesting for cardiac studies, because age is synonymous with heart disease in humans. Mitochondria are dynamic subcellular or...
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ftumanchesterpub:oai:pure.atira.dk:publications/87790d34-9650-440e-a7da-8b8ac6f5b108 2023-11-12T04:17:42+01:00 Fishing for Keys to Longevity in the Heart of the Greenland Shark Delaroche, Pierre Pinali, Christian Brayson, Daniel Félix López, Daniela Church, Stephanie Cooper, Garth JS Galli, Gina Bushnell, Peter G. Bernal, Diego Steffensen, John F. Shiels, Holly 2022-10-28 https://research.manchester.ac.uk/en/publications/87790d34-9650-440e-a7da-8b8ac6f5b108 https://www.physiology.org/docs/default-source/meeting/comparative-2022/comparative-program-book.pdf?sfvrsn=a25b5b4d_2 eng eng info:eu-repo/semantics/restrictedAccess Delaroche , P , Pinali , C , Brayson , D , Félix López , D , Church , S , Cooper , G JS , Galli , G , Bushnell , P G , Bernal , D , Steffensen , J F & Shiels , H 2022 , ' Fishing for Keys to Longevity in the Heart of the Greenland Shark ' , From Organisms to Omics in an Uncertain World American Physiological Society, Comparative Physiology. , San Diego , United States , 28/10/22 - 31/10/22 . conferenceObject 2022 ftumanchesterpub 2023-10-30T09:10:55Z The Greenland shark (Somniosus microcephalus) is the longest living vertebrate on the planet with a life span of at least 272 years. This extreme longevity is particularly interesting for cardiac studies, because age is synonymous with heart disease in humans. Mitochondria are dynamic subcellular organelles whose individual shape, organisation, and function are known to change with age. Similarly, age can alter nuclear form and function particularly in diseases associate with premature aging. We have used electron microscopy imaging and machine learning approaches, combined with metallomics and biochemical analyses in cardiac tissue from Greenland sharks between ~20 and ~200 years to better understand the role of these two key organelles in extreme longevity. We show mitochondrial volume densities were similar among individuals regardless of age (~20% of the myocardial volume). However, greater inner mitochondrial membrane (IMM) content was observed in larger (and thus presumably older) sharks. Metallomics showed that copper-levels were low in Greenland sharks compared with other species and did not change with age, which may indicate that the copper-based Complex IV of the mitochondrial respiratory-chain is less abundant in this species. Biochemical analyses revealed that little impact of age on mitochondrial function. Finally, we observed no change in nuclear morphology or heterochromatin content across the life span of the Greenland sharks assessed in this study. However, all sharks retained comparatively small nucleoli which is a hallmark of longevity across metazoans Conference Object Greenland Somniosus microcephalus The University of Manchester: Research Explorer |
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The University of Manchester: Research Explorer |
op_collection_id |
ftumanchesterpub |
language |
English |
description |
The Greenland shark (Somniosus microcephalus) is the longest living vertebrate on the planet with a life span of at least 272 years. This extreme longevity is particularly interesting for cardiac studies, because age is synonymous with heart disease in humans. Mitochondria are dynamic subcellular organelles whose individual shape, organisation, and function are known to change with age. Similarly, age can alter nuclear form and function particularly in diseases associate with premature aging. We have used electron microscopy imaging and machine learning approaches, combined with metallomics and biochemical analyses in cardiac tissue from Greenland sharks between ~20 and ~200 years to better understand the role of these two key organelles in extreme longevity. We show mitochondrial volume densities were similar among individuals regardless of age (~20% of the myocardial volume). However, greater inner mitochondrial membrane (IMM) content was observed in larger (and thus presumably older) sharks. Metallomics showed that copper-levels were low in Greenland sharks compared with other species and did not change with age, which may indicate that the copper-based Complex IV of the mitochondrial respiratory-chain is less abundant in this species. Biochemical analyses revealed that little impact of age on mitochondrial function. Finally, we observed no change in nuclear morphology or heterochromatin content across the life span of the Greenland sharks assessed in this study. However, all sharks retained comparatively small nucleoli which is a hallmark of longevity across metazoans |
format |
Conference Object |
author |
Delaroche, Pierre Pinali, Christian Brayson, Daniel Félix López, Daniela Church, Stephanie Cooper, Garth JS Galli, Gina Bushnell, Peter G. Bernal, Diego Steffensen, John F. Shiels, Holly |
spellingShingle |
Delaroche, Pierre Pinali, Christian Brayson, Daniel Félix López, Daniela Church, Stephanie Cooper, Garth JS Galli, Gina Bushnell, Peter G. Bernal, Diego Steffensen, John F. Shiels, Holly Fishing for Keys to Longevity in the Heart of the Greenland Shark |
author_facet |
Delaroche, Pierre Pinali, Christian Brayson, Daniel Félix López, Daniela Church, Stephanie Cooper, Garth JS Galli, Gina Bushnell, Peter G. Bernal, Diego Steffensen, John F. Shiels, Holly |
author_sort |
Delaroche, Pierre |
title |
Fishing for Keys to Longevity in the Heart of the Greenland Shark |
title_short |
Fishing for Keys to Longevity in the Heart of the Greenland Shark |
title_full |
Fishing for Keys to Longevity in the Heart of the Greenland Shark |
title_fullStr |
Fishing for Keys to Longevity in the Heart of the Greenland Shark |
title_full_unstemmed |
Fishing for Keys to Longevity in the Heart of the Greenland Shark |
title_sort |
fishing for keys to longevity in the heart of the greenland shark |
publishDate |
2022 |
url |
https://research.manchester.ac.uk/en/publications/87790d34-9650-440e-a7da-8b8ac6f5b108 https://www.physiology.org/docs/default-source/meeting/comparative-2022/comparative-program-book.pdf?sfvrsn=a25b5b4d_2 |
genre |
Greenland Somniosus microcephalus |
genre_facet |
Greenland Somniosus microcephalus |
op_source |
Delaroche , P , Pinali , C , Brayson , D , Félix López , D , Church , S , Cooper , G JS , Galli , G , Bushnell , P G , Bernal , D , Steffensen , J F & Shiels , H 2022 , ' Fishing for Keys to Longevity in the Heart of the Greenland Shark ' , From Organisms to Omics in an Uncertain World American Physiological Society, Comparative Physiology. , San Diego , United States , 28/10/22 - 31/10/22 . |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1782334498569977856 |