Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications
Enzymes are nature's catalysts and have great potential for sustainable processes from renewable resources. The adaptation of enzymes to the requirements of industrial processes is a prerequisite to harness their benefits in large-scale transformations for the synthesis of fine chemicals, food...
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ftumaastrichtcri:oai:cris.maastrichtuniversity.nl:publications/e6035288-f2de-4397-a565-9214ea6163cf 2023-05-15T13:57:42+02:00 Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications Noeth, Maximilian Gau, Elisabeth Jung, Falco Davari, Mehdi D. El-Awaad, Islam Pich, Andrij Schwaneberg, Ulrich 2020-12-07 https://cris.maastrichtuniversity.nl/en/publications/e6035288-f2de-4397-a565-9214ea6163cf https://doi.org/10.1039/d0gc03229h eng eng info:eu-repo/semantics/closedAccess Noeth , M , Gau , E , Jung , F , Davari , M D , El-Awaad , I , Pich , A & Schwaneberg , U 2020 , ' Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications ' , Green Chemistry , vol. 22 , no. 23 , pp. 8183-8209 . https://doi.org/10.1039/d0gc03229h MESOPOROUS SILICA NANOPARTICLES CRITICAL SOLUTION TEMPERATURE ENZYME IMMOBILIZATION GREEN CHEMISTRY PRECIPITATION POLYMERIZATION HORSERADISH-PEROXIDASE ENVIRONMENTALLY BENIGN BETA-GALACTOSIDASE CANDIDA-ANTARCTICA AQUEOUS MICROGELS article 2020 ftumaastrichtcri https://doi.org/10.1039/d0gc03229h 2022-07-19T09:14:45Z Enzymes are nature's catalysts and have great potential for sustainable processes from renewable resources. The adaptation of enzymes to the requirements of industrial processes is a prerequisite to harness their benefits in large-scale transformations for the synthesis of fine chemicals, food products, and pharmaceuticals. Immobilisation of wild-type or engineered enzymes using natural and synthetic carriers has been extensively employed to improve catalytic performance, ensure recovery and reuse, and thereby promote their use in industrial processes. Over the past three decades, significant progress has been achieved in the design and application of immobilised enzymes. Microgels as containers for protein immobilisation are advancing into a promising alternative as reflected by a growing body of literature that documents their use in sustainable catalytic processes. Microgels are crosslinked submicron-sized colloidal polymer networks and in this review, we summarise the progress in the synthesis and applications of enzyme-loaded microgels (mu-Gelzymes). We start by exploring the different approaches used for enzyme immobilisation on or within microgels and give representative examples for the use of mu-Gelzymes in different applications. Subsequently, the potential of mu-Gelzymes in achieving sustainable catalysis is discussed from a green chemistry perspective. Finally, we draw future directions for further improvement of biocatalytic mu-Gelzymes as an emerging interdisciplinary research field of interactive soft matter. Article in Journal/Newspaper Antarc* Antarctica Maastricht University Research Publications Green Chemistry 22 23 8183 8209 |
institution |
Open Polar |
collection |
Maastricht University Research Publications |
op_collection_id |
ftumaastrichtcri |
language |
English |
topic |
MESOPOROUS SILICA NANOPARTICLES CRITICAL SOLUTION TEMPERATURE ENZYME IMMOBILIZATION GREEN CHEMISTRY PRECIPITATION POLYMERIZATION HORSERADISH-PEROXIDASE ENVIRONMENTALLY BENIGN BETA-GALACTOSIDASE CANDIDA-ANTARCTICA AQUEOUS MICROGELS |
spellingShingle |
MESOPOROUS SILICA NANOPARTICLES CRITICAL SOLUTION TEMPERATURE ENZYME IMMOBILIZATION GREEN CHEMISTRY PRECIPITATION POLYMERIZATION HORSERADISH-PEROXIDASE ENVIRONMENTALLY BENIGN BETA-GALACTOSIDASE CANDIDA-ANTARCTICA AQUEOUS MICROGELS Noeth, Maximilian Gau, Elisabeth Jung, Falco Davari, Mehdi D. El-Awaad, Islam Pich, Andrij Schwaneberg, Ulrich Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications |
topic_facet |
MESOPOROUS SILICA NANOPARTICLES CRITICAL SOLUTION TEMPERATURE ENZYME IMMOBILIZATION GREEN CHEMISTRY PRECIPITATION POLYMERIZATION HORSERADISH-PEROXIDASE ENVIRONMENTALLY BENIGN BETA-GALACTOSIDASE CANDIDA-ANTARCTICA AQUEOUS MICROGELS |
description |
Enzymes are nature's catalysts and have great potential for sustainable processes from renewable resources. The adaptation of enzymes to the requirements of industrial processes is a prerequisite to harness their benefits in large-scale transformations for the synthesis of fine chemicals, food products, and pharmaceuticals. Immobilisation of wild-type or engineered enzymes using natural and synthetic carriers has been extensively employed to improve catalytic performance, ensure recovery and reuse, and thereby promote their use in industrial processes. Over the past three decades, significant progress has been achieved in the design and application of immobilised enzymes. Microgels as containers for protein immobilisation are advancing into a promising alternative as reflected by a growing body of literature that documents their use in sustainable catalytic processes. Microgels are crosslinked submicron-sized colloidal polymer networks and in this review, we summarise the progress in the synthesis and applications of enzyme-loaded microgels (mu-Gelzymes). We start by exploring the different approaches used for enzyme immobilisation on or within microgels and give representative examples for the use of mu-Gelzymes in different applications. Subsequently, the potential of mu-Gelzymes in achieving sustainable catalysis is discussed from a green chemistry perspective. Finally, we draw future directions for further improvement of biocatalytic mu-Gelzymes as an emerging interdisciplinary research field of interactive soft matter. |
format |
Article in Journal/Newspaper |
author |
Noeth, Maximilian Gau, Elisabeth Jung, Falco Davari, Mehdi D. El-Awaad, Islam Pich, Andrij Schwaneberg, Ulrich |
author_facet |
Noeth, Maximilian Gau, Elisabeth Jung, Falco Davari, Mehdi D. El-Awaad, Islam Pich, Andrij Schwaneberg, Ulrich |
author_sort |
Noeth, Maximilian |
title |
Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications |
title_short |
Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications |
title_full |
Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications |
title_fullStr |
Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications |
title_full_unstemmed |
Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications |
title_sort |
biocatalytic microgels (μ-gelzymes): synthesis, concepts, and emerging applications |
publishDate |
2020 |
url |
https://cris.maastrichtuniversity.nl/en/publications/e6035288-f2de-4397-a565-9214ea6163cf https://doi.org/10.1039/d0gc03229h |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Noeth , M , Gau , E , Jung , F , Davari , M D , El-Awaad , I , Pich , A & Schwaneberg , U 2020 , ' Biocatalytic microgels (μ-Gelzymes): synthesis, concepts, and emerging applications ' , Green Chemistry , vol. 22 , no. 23 , pp. 8183-8209 . https://doi.org/10.1039/d0gc03229h |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1039/d0gc03229h |
container_title |
Green Chemistry |
container_volume |
22 |
container_issue |
23 |
container_start_page |
8183 |
op_container_end_page |
8209 |
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1766265509632802816 |