Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome...
Published in: | Nature Genetics |
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2007
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Online Access: | https://cris.maastrichtuniversity.nl/en/publications/3004f8f7-bda1-47ea-b1e2-b0947d2a035b https://doi.org/10.1038/ng2062 |
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ftumaastrichtcri:oai:cris.maastrichtuniversity.nl:publications/3004f8f7-bda1-47ea-b1e2-b0947d2a035b 2023-05-15T16:49:45+02:00 Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes Gudmundsson, J. Sulem, P. Steinthorsdottir, V. Bergthorsson, J.T. Thorleifsson, G. Manolescu, A. Rafnar, T. Gudbjartsson, D. Agnarsson, B.A. Baker, A. Sigurdsson, A. Benediktsdottir, K.R. Jakobsdottir, M. Blondal, T. Stacey, S.N. Helgason, A. Gunnarsdottir, S. Olafsdottir, A. Kristinsson, K.T. Birgisdottir, B. Ghosh, S. Thorlacius, S. Magnusdottir, D. Stefansdottir, G. Kristjansson, K. Bagger, Y. Wilensky, R.L. Reilly, M.P. Morris, A.D. Kimber, C.H. Adeyemo, A. Chen, Y. Zhou, J. So, W.Y. Tong, P.C. Ng, M.C. Hansen, T. Andersen, G. Borch Johnsen, K. Jorgensen, T. Tres, A. Fuertes, F. Ruiz Echarri, M. Asin, L. Saez, B. van Boven, E. Klaver, S. Swinkels, D.W. Aben, K.K. Graif, T. 2007-01-01 https://cris.maastrichtuniversity.nl/en/publications/3004f8f7-bda1-47ea-b1e2-b0947d2a035b https://doi.org/10.1038/ng2062 eng eng info:eu-repo/semantics/closedAccess Gudmundsson , J , Sulem , P , Steinthorsdottir , V , Bergthorsson , J T , Thorleifsson , G , Manolescu , A , Rafnar , T , Gudbjartsson , D , Agnarsson , B A , Baker , A , Sigurdsson , A , Benediktsdottir , K R , Jakobsdottir , M , Blondal , T , Stacey , S N , Helgason , A , Gunnarsdottir , S , Olafsdottir , A , Kristinsson , K T , Birgisdottir , B , Ghosh , S , Thorlacius , S , Magnusdottir , D , Stefansdottir , G , Kristjansson , K , Bagger , Y , Wilensky , R L , Reilly , M P , Morris , A D , Kimber , C H , Adeyemo , A , Chen , Y , Zhou , J , So , W Y , Tong , P C , Ng , M C , Hansen , T , Andersen , G , Borch Johnsen , K , Jorgensen , T , Tres , A , Fuertes , F , Ruiz Echarri , M , Asin , L , Saez , B , van Boven , E , Klaver , S , Swinkels , D W , Aben , K K , Graif , T , Cashy , J , Suarez , B K , van Vierssen Trip , O , Frigge , M L , Ober , C , Hofker , M H , Wijmenga , C , Christiansen , C , Rader , D J , Palmer , C N , Rotimi , C , Chan , J C , Pedersen , O , Sigurdsson , G , Benediktsson , R , Jonsson , E , Einarsson , G V , Mayordomo , J I , Catalona , W J , Kiemeney , L A , Barkardottir , R B , Gulcher , J R , Thorsteinsdottir , U , Kong , A & Stefansson , K 2007 , ' Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes ' , Nature Genetics , vol. 39 , no. 8 , pp. 977-983 . https://doi.org/10.1038/ng2062 article 2007 ftumaastrichtcri https://doi.org/10.1038/ng2062 2022-07-19T08:57:12Z We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes. AD - [1] deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland. [2] These authors contributed equally to this work. Article in Journal/Newspaper Iceland Maastricht University Research Publications Nature Genetics 39 8 977 983 |
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Maastricht University Research Publications |
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ftumaastrichtcri |
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English |
description |
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes. AD - [1] deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland. [2] These authors contributed equally to this work. |
format |
Article in Journal/Newspaper |
author |
Gudmundsson, J. Sulem, P. Steinthorsdottir, V. Bergthorsson, J.T. Thorleifsson, G. Manolescu, A. Rafnar, T. Gudbjartsson, D. Agnarsson, B.A. Baker, A. Sigurdsson, A. Benediktsdottir, K.R. Jakobsdottir, M. Blondal, T. Stacey, S.N. Helgason, A. Gunnarsdottir, S. Olafsdottir, A. Kristinsson, K.T. Birgisdottir, B. Ghosh, S. Thorlacius, S. Magnusdottir, D. Stefansdottir, G. Kristjansson, K. Bagger, Y. Wilensky, R.L. Reilly, M.P. Morris, A.D. Kimber, C.H. Adeyemo, A. Chen, Y. Zhou, J. So, W.Y. Tong, P.C. Ng, M.C. Hansen, T. Andersen, G. Borch Johnsen, K. Jorgensen, T. Tres, A. Fuertes, F. Ruiz Echarri, M. Asin, L. Saez, B. van Boven, E. Klaver, S. Swinkels, D.W. Aben, K.K. Graif, T. |
spellingShingle |
Gudmundsson, J. Sulem, P. Steinthorsdottir, V. Bergthorsson, J.T. Thorleifsson, G. Manolescu, A. Rafnar, T. Gudbjartsson, D. Agnarsson, B.A. Baker, A. Sigurdsson, A. Benediktsdottir, K.R. Jakobsdottir, M. Blondal, T. Stacey, S.N. Helgason, A. Gunnarsdottir, S. Olafsdottir, A. Kristinsson, K.T. Birgisdottir, B. Ghosh, S. Thorlacius, S. Magnusdottir, D. Stefansdottir, G. Kristjansson, K. Bagger, Y. Wilensky, R.L. Reilly, M.P. Morris, A.D. Kimber, C.H. Adeyemo, A. Chen, Y. Zhou, J. So, W.Y. Tong, P.C. Ng, M.C. Hansen, T. Andersen, G. Borch Johnsen, K. Jorgensen, T. Tres, A. Fuertes, F. Ruiz Echarri, M. Asin, L. Saez, B. van Boven, E. Klaver, S. Swinkels, D.W. Aben, K.K. Graif, T. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes |
author_facet |
Gudmundsson, J. Sulem, P. Steinthorsdottir, V. Bergthorsson, J.T. Thorleifsson, G. Manolescu, A. Rafnar, T. Gudbjartsson, D. Agnarsson, B.A. Baker, A. Sigurdsson, A. Benediktsdottir, K.R. Jakobsdottir, M. Blondal, T. Stacey, S.N. Helgason, A. Gunnarsdottir, S. Olafsdottir, A. Kristinsson, K.T. Birgisdottir, B. Ghosh, S. Thorlacius, S. Magnusdottir, D. Stefansdottir, G. Kristjansson, K. Bagger, Y. Wilensky, R.L. Reilly, M.P. Morris, A.D. Kimber, C.H. Adeyemo, A. Chen, Y. Zhou, J. So, W.Y. Tong, P.C. Ng, M.C. Hansen, T. Andersen, G. Borch Johnsen, K. Jorgensen, T. Tres, A. Fuertes, F. Ruiz Echarri, M. Asin, L. Saez, B. van Boven, E. Klaver, S. Swinkels, D.W. Aben, K.K. Graif, T. |
author_sort |
Gudmundsson, J. |
title |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes |
title_short |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes |
title_full |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes |
title_fullStr |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes |
title_full_unstemmed |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes |
title_sort |
two variants on chromosome 17 confer prostate cancer risk, and the one in tcf2 protects against type 2 diabetes |
publishDate |
2007 |
url |
https://cris.maastrichtuniversity.nl/en/publications/3004f8f7-bda1-47ea-b1e2-b0947d2a035b https://doi.org/10.1038/ng2062 |
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Iceland |
genre_facet |
Iceland |
op_source |
Gudmundsson , J , Sulem , P , Steinthorsdottir , V , Bergthorsson , J T , Thorleifsson , G , Manolescu , A , Rafnar , T , Gudbjartsson , D , Agnarsson , B A , Baker , A , Sigurdsson , A , Benediktsdottir , K R , Jakobsdottir , M , Blondal , T , Stacey , S N , Helgason , A , Gunnarsdottir , S , Olafsdottir , A , Kristinsson , K T , Birgisdottir , B , Ghosh , S , Thorlacius , S , Magnusdottir , D , Stefansdottir , G , Kristjansson , K , Bagger , Y , Wilensky , R L , Reilly , M P , Morris , A D , Kimber , C H , Adeyemo , A , Chen , Y , Zhou , J , So , W Y , Tong , P C , Ng , M C , Hansen , T , Andersen , G , Borch Johnsen , K , Jorgensen , T , Tres , A , Fuertes , F , Ruiz Echarri , M , Asin , L , Saez , B , van Boven , E , Klaver , S , Swinkels , D W , Aben , K K , Graif , T , Cashy , J , Suarez , B K , van Vierssen Trip , O , Frigge , M L , Ober , C , Hofker , M H , Wijmenga , C , Christiansen , C , Rader , D J , Palmer , C N , Rotimi , C , Chan , J C , Pedersen , O , Sigurdsson , G , Benediktsson , R , Jonsson , E , Einarsson , G V , Mayordomo , J I , Catalona , W J , Kiemeney , L A , Barkardottir , R B , Gulcher , J R , Thorsteinsdottir , U , Kong , A & Stefansson , K 2007 , ' Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes ' , Nature Genetics , vol. 39 , no. 8 , pp. 977-983 . https://doi.org/10.1038/ng2062 |
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info:eu-repo/semantics/closedAccess |
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https://doi.org/10.1038/ng2062 |
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