Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics
Objectives Exposure to persistent organohalogen pollutants was suggested to impair male reproductive function. A gene-environment interaction has been proposed. No genes modifying the effect of persistent organohalogen pollutants on reproductive organs have yet been identified. We aimed to investiga...
Published in: | Pharmacogenetics and Genomics |
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Main Authors: | , , , , , , , , , , , , , , , , |
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Language: | English |
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Lippincott Williams & Wilkins
2007
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Online Access: | https://lup.lub.lu.se/record/650651 https://doi.org/10.1097/01.fpc.0000236329.26551.78 |
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ftulundlup:oai:lup.lub.lu.se:fabd45bf-4ed4-4654-baea-1a7d46b35813 2023-05-15T16:30:02+02:00 Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics Giwercman, Aleksander Rylander, Lars Rignell-Hydbom, Anna Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Lesovoy, Vladimir Zvyezday, Valentyna Spano, Marcello Manicardi, Gian-Carlo Bizzaro, Davide Bonefeld-Jorgensen, Eva C. Toft, Gunnar Bonde, Jens Peter Giwercman, Charlotte Tiido, Tarmo Giwercman, Yvonne 2007 https://lup.lub.lu.se/record/650651 https://doi.org/10.1097/01.fpc.0000236329.26551.78 eng eng Lippincott Williams & Wilkins https://lup.lub.lu.se/record/650651 http://dx.doi.org/10.1097/01.fpc.0000236329.26551.78 wos:000246931900002 scopus:33847668918 Pharmacogenetics & Genomics; 17(6), pp 391-401 (2007) ISSN: 1744-6872 Pharmacology and Toxicology persistent organohalogen pollutants gene-environment interaction androgen receptor CAG repeats semen quality contributiontojournal/article info:eu-repo/semantics/article text 2007 ftulundlup https://doi.org/10.1097/01.fpc.0000236329.26551.78 2023-02-01T23:28:34Z Objectives Exposure to persistent organohalogen pollutants was suggested to impair male reproductive function. A gene-environment interaction has been proposed. No genes modifying the effect of persistent organohalogen pollutants on reproductive organs have yet been identified. We aimed to investigate whether the CAG and GGN polymorphisms in the androgen receptor gene modify the effect of persistent organohalogen pollutant exposure on human sperm characteristics. Methods Semen and blood from 680 men [mean (SD) age 34 (10) years] from Greenland, Sweden, Warsaw (Poland) and Kharkiv (Ukraine) were collected. Persistent organohalogen pollutant exposure was assessed by measuring serum levels of 2,2,4,4,5,5'-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p'-DDE). Semen characteristics (volume, sperm concentration, total count proportion of progressively motile and morphology) and DNA fragmentation index (DFI) were determined. CAG and GGN repeat lengths were determined by direct sequencing of leukocyte DNA. Results A statistically significant interaction was found between the CB-153 group and CAG repeat category in relation to sperm concentration and total sperm count (P=0.03 and 0.01, respectively). For p,p'-DDE, in the European cohorts a significant interaction was found in relation to DFI (P=0.01). For CAG<20, sperm concentration and total sperm count were 35 and 42% lower, respectively, when the group with CB-153 exposure above median was compared with that below the median. DF1 was 40% higher in the high p,p'-DDE exposure group for CAG < 21. Conclusions This study indicated that the androgen receptor CAG repeat length might modify the susceptibility of an individual to the adverse effects of persistent organohalogen pollutant exposure on semen quality. Other studies regarding this matter are warranted. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Greenland Pharmacogenetics and Genomics 17 6 391 401 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Pharmacology and Toxicology persistent organohalogen pollutants gene-environment interaction androgen receptor CAG repeats semen quality |
spellingShingle |
Pharmacology and Toxicology persistent organohalogen pollutants gene-environment interaction androgen receptor CAG repeats semen quality Giwercman, Aleksander Rylander, Lars Rignell-Hydbom, Anna Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Lesovoy, Vladimir Zvyezday, Valentyna Spano, Marcello Manicardi, Gian-Carlo Bizzaro, Davide Bonefeld-Jorgensen, Eva C. Toft, Gunnar Bonde, Jens Peter Giwercman, Charlotte Tiido, Tarmo Giwercman, Yvonne Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
topic_facet |
Pharmacology and Toxicology persistent organohalogen pollutants gene-environment interaction androgen receptor CAG repeats semen quality |
description |
Objectives Exposure to persistent organohalogen pollutants was suggested to impair male reproductive function. A gene-environment interaction has been proposed. No genes modifying the effect of persistent organohalogen pollutants on reproductive organs have yet been identified. We aimed to investigate whether the CAG and GGN polymorphisms in the androgen receptor gene modify the effect of persistent organohalogen pollutant exposure on human sperm characteristics. Methods Semen and blood from 680 men [mean (SD) age 34 (10) years] from Greenland, Sweden, Warsaw (Poland) and Kharkiv (Ukraine) were collected. Persistent organohalogen pollutant exposure was assessed by measuring serum levels of 2,2,4,4,5,5'-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p'-DDE). Semen characteristics (volume, sperm concentration, total count proportion of progressively motile and morphology) and DNA fragmentation index (DFI) were determined. CAG and GGN repeat lengths were determined by direct sequencing of leukocyte DNA. Results A statistically significant interaction was found between the CB-153 group and CAG repeat category in relation to sperm concentration and total sperm count (P=0.03 and 0.01, respectively). For p,p'-DDE, in the European cohorts a significant interaction was found in relation to DFI (P=0.01). For CAG<20, sperm concentration and total sperm count were 35 and 42% lower, respectively, when the group with CB-153 exposure above median was compared with that below the median. DF1 was 40% higher in the high p,p'-DDE exposure group for CAG < 21. Conclusions This study indicated that the androgen receptor CAG repeat length might modify the susceptibility of an individual to the adverse effects of persistent organohalogen pollutant exposure on semen quality. Other studies regarding this matter are warranted. |
format |
Article in Journal/Newspaper |
author |
Giwercman, Aleksander Rylander, Lars Rignell-Hydbom, Anna Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Lesovoy, Vladimir Zvyezday, Valentyna Spano, Marcello Manicardi, Gian-Carlo Bizzaro, Davide Bonefeld-Jorgensen, Eva C. Toft, Gunnar Bonde, Jens Peter Giwercman, Charlotte Tiido, Tarmo Giwercman, Yvonne |
author_facet |
Giwercman, Aleksander Rylander, Lars Rignell-Hydbom, Anna Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Lesovoy, Vladimir Zvyezday, Valentyna Spano, Marcello Manicardi, Gian-Carlo Bizzaro, Davide Bonefeld-Jorgensen, Eva C. Toft, Gunnar Bonde, Jens Peter Giwercman, Charlotte Tiido, Tarmo Giwercman, Yvonne |
author_sort |
Giwercman, Aleksander |
title |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
title_short |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
title_full |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
title_fullStr |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
title_full_unstemmed |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
title_sort |
androgen receptor gene cag repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2007 |
url |
https://lup.lub.lu.se/record/650651 https://doi.org/10.1097/01.fpc.0000236329.26551.78 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Pharmacogenetics & Genomics; 17(6), pp 391-401 (2007) ISSN: 1744-6872 |
op_relation |
https://lup.lub.lu.se/record/650651 http://dx.doi.org/10.1097/01.fpc.0000236329.26551.78 wos:000246931900002 scopus:33847668918 |
op_doi |
https://doi.org/10.1097/01.fpc.0000236329.26551.78 |
container_title |
Pharmacogenetics and Genomics |
container_volume |
17 |
container_issue |
6 |
container_start_page |
391 |
op_container_end_page |
401 |
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1766019748387094528 |