Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process
An analysis of an out-of-equilibrium cyclic reaction network which continuously converts a minor undesired product enantiomer to the desired major enantiomer by irreversible addition of chemical fuel and irreversible elimination of spent fuel is presented. The reaction network is maintained as long...
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Format: | Article in Journal/Newspaper |
Language: | English |
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2024
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Online Access: | https://lup.lub.lu.se/record/faad1713-d01c-444c-b615-0da35ba9901f https://doi.org/10.1002/syst.202300045 |
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ftulundlup:oai:lup.lub.lu.se:faad1713-d01c-444c-b615-0da35ba9901f 2024-05-12T08:02:20+00:00 Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S.G. Wendt, Ola F. Fransson, Linda Moberg, Christina 2024 https://lup.lub.lu.se/record/faad1713-d01c-444c-b615-0da35ba9901f https://doi.org/10.1002/syst.202300045 eng eng Wiley https://lup.lub.lu.se/record/faad1713-d01c-444c-b615-0da35ba9901f http://dx.doi.org/10.1002/syst.202300045 scopus:85187624737 ChemSystemsChem; 6(2), no e202300045 (2024) ISSN: 2570-4206 Chemical Process Engineering catalysts enantioselective kinetic modeling out-of-equilibrium systems regulation contributiontojournal/article info:eu-repo/semantics/article text 2024 ftulundlup https://doi.org/10.1002/syst.202300045 2024-04-17T14:16:17Z An analysis of an out-of-equilibrium cyclic reaction network which continuously converts a minor undesired product enantiomer to the desired major enantiomer by irreversible addition of chemical fuel and irreversible elimination of spent fuel is presented. The reaction network is maintained as long as fuel is added; interrupted fuel addition drives the system towards equilibrium, but the cyclic process restarts upon resumed fuel addition, as demonstrated by three consecutive fuel cycles. The process is powered by the hydrolysis of methyl cyanoformate to HCN and monomethyl carbonic acid, which decomposes to CO2 and MeOH. The time it takes to reach steady state depends on the rate of conversion of the fuel and decreases with increased conversion rate. Three catalysts, one metal catalyst and two enzymes, together constitute an efficient regulation system allowing control of the forward, backward and waste-forming steps, thereby assuring the production of high yields of products with high enantiopurity. Article in Journal/Newspaper Carbonic acid Lund University Publications (LUP) ChemSystemsChem 6 2 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Chemical Process Engineering catalysts enantioselective kinetic modeling out-of-equilibrium systems regulation |
spellingShingle |
Chemical Process Engineering catalysts enantioselective kinetic modeling out-of-equilibrium systems regulation Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S.G. Wendt, Ola F. Fransson, Linda Moberg, Christina Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process |
topic_facet |
Chemical Process Engineering catalysts enantioselective kinetic modeling out-of-equilibrium systems regulation |
description |
An analysis of an out-of-equilibrium cyclic reaction network which continuously converts a minor undesired product enantiomer to the desired major enantiomer by irreversible addition of chemical fuel and irreversible elimination of spent fuel is presented. The reaction network is maintained as long as fuel is added; interrupted fuel addition drives the system towards equilibrium, but the cyclic process restarts upon resumed fuel addition, as demonstrated by three consecutive fuel cycles. The process is powered by the hydrolysis of methyl cyanoformate to HCN and monomethyl carbonic acid, which decomposes to CO2 and MeOH. The time it takes to reach steady state depends on the rate of conversion of the fuel and decreases with increased conversion rate. Three catalysts, one metal catalyst and two enzymes, together constitute an efficient regulation system allowing control of the forward, backward and waste-forming steps, thereby assuring the production of high yields of products with high enantiopurity. |
format |
Article in Journal/Newspaper |
author |
Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S.G. Wendt, Ola F. Fransson, Linda Moberg, Christina |
author_facet |
Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S.G. Wendt, Ola F. Fransson, Linda Moberg, Christina |
author_sort |
Margarita, Cristiana |
title |
Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_short |
Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_full |
Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_fullStr |
Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_full_unstemmed |
Dissipative Cyclic Reaction Networks : Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_sort |
dissipative cyclic reaction networks : mechanistic insights into a minor enantiomer recycling process |
publisher |
Wiley |
publishDate |
2024 |
url |
https://lup.lub.lu.se/record/faad1713-d01c-444c-b615-0da35ba9901f https://doi.org/10.1002/syst.202300045 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
ChemSystemsChem; 6(2), no e202300045 (2024) ISSN: 2570-4206 |
op_relation |
https://lup.lub.lu.se/record/faad1713-d01c-444c-b615-0da35ba9901f http://dx.doi.org/10.1002/syst.202300045 scopus:85187624737 |
op_doi |
https://doi.org/10.1002/syst.202300045 |
container_title |
ChemSystemsChem |
container_volume |
6 |
container_issue |
2 |
_version_ |
1798844429754171392 |