Epididymal and accessory sex gland function and semen quality
Infertility, defined as the inability to conceive after one year of unprotected regular intercourse, affects up to 15% of all couples of reproductive age. The infertility can originate from female, male or both partners. In up to 50% of the affected couples, a male factor is the cause of infertility...
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Medicinsk Informationsteknik, Malmö
2005
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ftulundlup:oai:lup.lub.lu.se:f5c907da-3ba4-4929-a94d-e14e84c0d1b6 2023-05-15T16:30:29+02:00 Epididymal and accessory sex gland function and semen quality Elzanaty, Saad 2005 https://lup.lub.lu.se/record/545622 eng eng Medicinsk Informationsteknik, Malmö https://lup.lub.lu.se/record/545622 urn:isbn:91-85481-00-9 Clinical Medicine Medicin (människa och djur) Medicine (human and vertebrates) zinc visco-elasticity sperm motility SDR5A2 PSA persistent organohalogen pollutants NAG fructose Epididymis CASA acessory sex gland abstinence period thesis/doccomp info:eu-repo/semantics/doctoralThesis text 2005 ftulundlup 2023-02-01T23:27:11Z Infertility, defined as the inability to conceive after one year of unprotected regular intercourse, affects up to 15% of all couples of reproductive age. The infertility can originate from female, male or both partners. In up to 50% of the affected couples, a male factor is the cause of infertility. Semen analysis is the cornerstone of male infertility assessment and an abnormal result often triggers a referral for a specialist opinion. It has been hypothesized that epididymal and accessory sex gland dysfunction are involved in pathophysiologies affecting male fertility. However, our knowledge within this area is still very limited. The aims of this study were, therefore, 1) To examine the association between the markers of epididymal (neutral ?-glucosidase [NAG]), prostatic (prostate-specific antigen [PSA] and zinc), and seminal vesicles (fructose) function and the motility of spermatozoa; 2) To examine the association between the function of these organs and semen visco-elasticity, the length of sexual abstinence and the impact of these two factors on sperm motility in men under infertility assessment; 3) To assess the association between 5?-reductase type 2 gene (SD2R5A) polymorphisms and semen parameters in men from the general population; 4) Finally, to explore the association between exposure to persistent organohalogen pollutants (POPs) and epididymal and accessory sex gland function in a group of Swedish fishermen , fertile men from Greenland, Warsaw, (Poland) and Kharkiv, (Ukraine). Our study demonstrated a positive association between the epididymal marker NAG as well as the prostatic marker PSA and the motility of spermatozoa. Hyperfunction of seminal vesicles was associated with high visco-elasticity and lower proportion of motile spermatozoa. Compared to men delivering semen samples after 4?5 days, those having 2?3 days abstinence presented with lower NAG, zinc and proportion of motile sperm whereas those who delivered samples after 6?7 days exhibited higher percentage spermatozoa with tail defects ... Doctoral or Postdoctoral Thesis Greenland Lund University Publications (LUP) Greenland |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Clinical Medicine Medicin (människa och djur) Medicine (human and vertebrates) zinc visco-elasticity sperm motility SDR5A2 PSA persistent organohalogen pollutants NAG fructose Epididymis CASA acessory sex gland abstinence period |
spellingShingle |
Clinical Medicine Medicin (människa och djur) Medicine (human and vertebrates) zinc visco-elasticity sperm motility SDR5A2 PSA persistent organohalogen pollutants NAG fructose Epididymis CASA acessory sex gland abstinence period Elzanaty, Saad Epididymal and accessory sex gland function and semen quality |
topic_facet |
Clinical Medicine Medicin (människa och djur) Medicine (human and vertebrates) zinc visco-elasticity sperm motility SDR5A2 PSA persistent organohalogen pollutants NAG fructose Epididymis CASA acessory sex gland abstinence period |
description |
Infertility, defined as the inability to conceive after one year of unprotected regular intercourse, affects up to 15% of all couples of reproductive age. The infertility can originate from female, male or both partners. In up to 50% of the affected couples, a male factor is the cause of infertility. Semen analysis is the cornerstone of male infertility assessment and an abnormal result often triggers a referral for a specialist opinion. It has been hypothesized that epididymal and accessory sex gland dysfunction are involved in pathophysiologies affecting male fertility. However, our knowledge within this area is still very limited. The aims of this study were, therefore, 1) To examine the association between the markers of epididymal (neutral ?-glucosidase [NAG]), prostatic (prostate-specific antigen [PSA] and zinc), and seminal vesicles (fructose) function and the motility of spermatozoa; 2) To examine the association between the function of these organs and semen visco-elasticity, the length of sexual abstinence and the impact of these two factors on sperm motility in men under infertility assessment; 3) To assess the association between 5?-reductase type 2 gene (SD2R5A) polymorphisms and semen parameters in men from the general population; 4) Finally, to explore the association between exposure to persistent organohalogen pollutants (POPs) and epididymal and accessory sex gland function in a group of Swedish fishermen , fertile men from Greenland, Warsaw, (Poland) and Kharkiv, (Ukraine). Our study demonstrated a positive association between the epididymal marker NAG as well as the prostatic marker PSA and the motility of spermatozoa. Hyperfunction of seminal vesicles was associated with high visco-elasticity and lower proportion of motile spermatozoa. Compared to men delivering semen samples after 4?5 days, those having 2?3 days abstinence presented with lower NAG, zinc and proportion of motile sperm whereas those who delivered samples after 6?7 days exhibited higher percentage spermatozoa with tail defects ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Elzanaty, Saad |
author_facet |
Elzanaty, Saad |
author_sort |
Elzanaty, Saad |
title |
Epididymal and accessory sex gland function and semen quality |
title_short |
Epididymal and accessory sex gland function and semen quality |
title_full |
Epididymal and accessory sex gland function and semen quality |
title_fullStr |
Epididymal and accessory sex gland function and semen quality |
title_full_unstemmed |
Epididymal and accessory sex gland function and semen quality |
title_sort |
epididymal and accessory sex gland function and semen quality |
publisher |
Medicinsk Informationsteknik, Malmö |
publishDate |
2005 |
url |
https://lup.lub.lu.se/record/545622 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
https://lup.lub.lu.se/record/545622 urn:isbn:91-85481-00-9 |
_version_ |
1766020219200864256 |