Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The assoc...
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Online Access: | https://lup.lub.lu.se/record/f5c018a9-3625-4c16-b413-fbe6a210883b https://doi.org/10.4103/1008-682X.186870 |
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ftulundlup:oai:lup.lub.lu.se:f5c018a9-3625-4c16-b413-fbe6a210883b 2024-04-21T08:12:49+00:00 Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage Malm, Gunilla Haugen, Trine B Rylander, Lars Giwercman, Aleksander 2017 https://lup.lub.lu.se/record/f5c018a9-3625-4c16-b413-fbe6a210883b https://doi.org/10.4103/1008-682X.186870 eng eng Nature Publishing Group https://lup.lub.lu.se/record/f5c018a9-3625-4c16-b413-fbe6a210883b http://dx.doi.org/10.4103/1008-682X.186870 scopus:85008701868 pmid:27748316 wos:000392108300010 Asian Journal of Andrology; 19(1), pp 52-56 (2017) ISSN: 1008-682X Environmental Health and Occupational Health male infertility melatonin semen quality sperm DNA index contributiontojournal/article info:eu-repo/semantics/article text 2017 ftulundlup https://doi.org/10.4103/1008-682X.186870 2024-03-27T15:02:47Z A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter-early summer) in aMT6s and DFI were for the total cohort: rho = -0.08 (P = 0.322), for the Oslo cohort: rho = -0.07 (P = 0.485), and for the Tromsoe cohort: rho = -0.14 (P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. Article in Journal/Newspaper Tromsoe Lund University Publications (LUP) Asian Journal of Andrology 0 0 0 |
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Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health male infertility melatonin semen quality sperm DNA index |
spellingShingle |
Environmental Health and Occupational Health male infertility melatonin semen quality sperm DNA index Malm, Gunilla Haugen, Trine B Rylander, Lars Giwercman, Aleksander Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
topic_facet |
Environmental Health and Occupational Health male infertility melatonin semen quality sperm DNA index |
description |
A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter-early summer) in aMT6s and DFI were for the total cohort: rho = -0.08 (P = 0.322), for the Oslo cohort: rho = -0.07 (P = 0.485), and for the Tromsoe cohort: rho = -0.14 (P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. |
format |
Article in Journal/Newspaper |
author |
Malm, Gunilla Haugen, Trine B Rylander, Lars Giwercman, Aleksander |
author_facet |
Malm, Gunilla Haugen, Trine B Rylander, Lars Giwercman, Aleksander |
author_sort |
Malm, Gunilla |
title |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_short |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_full |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_fullStr |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_full_unstemmed |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_sort |
seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm dna damage |
publisher |
Nature Publishing Group |
publishDate |
2017 |
url |
https://lup.lub.lu.se/record/f5c018a9-3625-4c16-b413-fbe6a210883b https://doi.org/10.4103/1008-682X.186870 |
genre |
Tromsoe |
genre_facet |
Tromsoe |
op_source |
Asian Journal of Andrology; 19(1), pp 52-56 (2017) ISSN: 1008-682X |
op_relation |
https://lup.lub.lu.se/record/f5c018a9-3625-4c16-b413-fbe6a210883b http://dx.doi.org/10.4103/1008-682X.186870 scopus:85008701868 pmid:27748316 wos:000392108300010 |
op_doi |
https://doi.org/10.4103/1008-682X.186870 |
container_title |
Asian Journal of Andrology |
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1796932998760759296 |