Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants
Baltic herring (Clupea harengus) oil was extracted and fractionated. To examine the contribution to toxicity and biological effects of different halogenated organic pollutants, the herring oil and the fractions were mixed into pelleted food and given to Sprague-Dawley female rats at three levels, co...
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ftulundlup:oai:lup.lub.lu.se:ef2d2e77-a5cf-4e4f-af6c-25caafe02a5f 2023-05-15T17:24:15+02:00 Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants Oberg, M Stern, N Jensen, S Wesén, Clas Haglund, P Casabona, H Johansson, N Blomgren, K Hakansson, H 2002 https://lup.lub.lu.se/record/322741 https://doi.org/10.1034/j.1600-0773.2002.910503.x eng eng Wiley-Blackwell https://lup.lub.lu.se/record/322741 http://dx.doi.org/10.1034/j.1600-0773.2002.910503.x pmid:12570029 wos:000179448900003 scopus:0036852299 Pharmacology and Toxicology; 91(5), pp 220-231 (2002) ISSN: 1600-0773 Analytical Chemistry contributiontojournal/article info:eu-repo/semantics/article text 2002 ftulundlup https://doi.org/10.1034/j.1600-0773.2002.910503.x 2023-02-01T23:28:26Z Baltic herring (Clupea harengus) oil was extracted and fractionated. To examine the contribution to toxicity and biological effects of different halogenated organic pollutants, the herring oil and the fractions were mixed into pelleted food and given to Sprague-Dawley female rats at three levels, corresponding to a human intake of 1.6, 8.2 and 34.4 kg fish per week. Herring oil, its fractions, as well as liver tissues from exposed rats, were analyzed for: eight chlorinated biphenyls, all 2,3,7,8-substituted chlorinated dibenzo-p-dioxins and dibenzofurans, hexachlorocyclohexanes, hexachlorobenzene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), DDT-metabolites, three brominated diphenylethers as well as extractable organically bound chlorine and halogenated fatty acids. A bioassay (EROD) was used for measuring the dioxin-like enzyme induction activity. Nordic Sea lodda (Mallotus villosus) oil was used as a nutritionally equivalent control, with much lower levels of halogenated organic pollutants. A full toxicological subchronic examination is reported in the following paper (Stern et al. 2002). In this study, we report that the fractionation procedure resulted in a substantial reduction of most of the pollutants in the triacylglycerol fraction, and a pronounced enrichment of most of the pollutants into the two other fractions. However, all contaminants were present at some levels in all of the fractions. The concentrations of organoltalogens found in this study were representative for Baltic herring during the mid-1990s. Rat liver tissue showed similar residue patterns as the diet, with the exception of chlorinated dibenzo-p-dioxin and dibenzofuran congeners that had a higher liver retention than pesticides, chlorinated biphenyls and brominated diphenylethers. Article in Journal/Newspaper Nordic Sea Lund University Publications (LUP) Pharmacology & Toxicology 91 5 220 231 |
institution |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Analytical Chemistry |
spellingShingle |
Analytical Chemistry Oberg, M Stern, N Jensen, S Wesén, Clas Haglund, P Casabona, H Johansson, N Blomgren, K Hakansson, H Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants |
topic_facet |
Analytical Chemistry |
description |
Baltic herring (Clupea harengus) oil was extracted and fractionated. To examine the contribution to toxicity and biological effects of different halogenated organic pollutants, the herring oil and the fractions were mixed into pelleted food and given to Sprague-Dawley female rats at three levels, corresponding to a human intake of 1.6, 8.2 and 34.4 kg fish per week. Herring oil, its fractions, as well as liver tissues from exposed rats, were analyzed for: eight chlorinated biphenyls, all 2,3,7,8-substituted chlorinated dibenzo-p-dioxins and dibenzofurans, hexachlorocyclohexanes, hexachlorobenzene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), DDT-metabolites, three brominated diphenylethers as well as extractable organically bound chlorine and halogenated fatty acids. A bioassay (EROD) was used for measuring the dioxin-like enzyme induction activity. Nordic Sea lodda (Mallotus villosus) oil was used as a nutritionally equivalent control, with much lower levels of halogenated organic pollutants. A full toxicological subchronic examination is reported in the following paper (Stern et al. 2002). In this study, we report that the fractionation procedure resulted in a substantial reduction of most of the pollutants in the triacylglycerol fraction, and a pronounced enrichment of most of the pollutants into the two other fractions. However, all contaminants were present at some levels in all of the fractions. The concentrations of organoltalogens found in this study were representative for Baltic herring during the mid-1990s. Rat liver tissue showed similar residue patterns as the diet, with the exception of chlorinated dibenzo-p-dioxin and dibenzofuran congeners that had a higher liver retention than pesticides, chlorinated biphenyls and brominated diphenylethers. |
format |
Article in Journal/Newspaper |
author |
Oberg, M Stern, N Jensen, S Wesén, Clas Haglund, P Casabona, H Johansson, N Blomgren, K Hakansson, H |
author_facet |
Oberg, M Stern, N Jensen, S Wesén, Clas Haglund, P Casabona, H Johansson, N Blomgren, K Hakansson, H |
author_sort |
Oberg, M |
title |
Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants |
title_short |
Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants |
title_full |
Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants |
title_fullStr |
Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants |
title_full_unstemmed |
Subchronic toxicity of Baltic herring oil and its fractions in the rat I: Fractionation and levels of organohalogen pollutants |
title_sort |
subchronic toxicity of baltic herring oil and its fractions in the rat i: fractionation and levels of organohalogen pollutants |
publisher |
Wiley-Blackwell |
publishDate |
2002 |
url |
https://lup.lub.lu.se/record/322741 https://doi.org/10.1034/j.1600-0773.2002.910503.x |
genre |
Nordic Sea |
genre_facet |
Nordic Sea |
op_source |
Pharmacology and Toxicology; 91(5), pp 220-231 (2002) ISSN: 1600-0773 |
op_relation |
https://lup.lub.lu.se/record/322741 http://dx.doi.org/10.1034/j.1600-0773.2002.910503.x pmid:12570029 wos:000179448900003 scopus:0036852299 |
op_doi |
https://doi.org/10.1034/j.1600-0773.2002.910503.x |
container_title |
Pharmacology & Toxicology |
container_volume |
91 |
container_issue |
5 |
container_start_page |
220 |
op_container_end_page |
231 |
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1766115180580700160 |