Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men.
Abstract Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if lo...
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Informa Healthcare
2013
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Online Access: | https://lup.lub.lu.se/record/3628034 https://doi.org/10.3109/13685538.2013.772134 https://portal.research.lu.se/files/1543792/3910622.pdf |
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ftulundlup:oai:lup.lub.lu.se:eef9f42a-5f3f-479e-8575-7ede619f27d4 2023-05-15T18:34:40+02:00 Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. Linnér, Carl Svartberg, Johan Giwercman, Aleksander Giwercman, Yvonne Lundberg 2013 application/pdf https://lup.lub.lu.se/record/3628034 https://doi.org/10.3109/13685538.2013.772134 https://portal.research.lu.se/files/1543792/3910622.pdf eng eng Informa Healthcare https://lup.lub.lu.se/record/3628034 http://dx.doi.org/10.3109/13685538.2013.772134 https://portal.research.lu.se/files/1543792/3910622.pdf wos:000319129900005 pmid:23506158 scopus:84877935394 info:eu-repo/semantics/openAccess The Aging Male; 16(2), pp 52-57 (2013) ISSN: 1473-0790 Obstetrics Gynecology and Reproductive Medicine contributiontojournal/article info:eu-repo/semantics/article text 2013 ftulundlup https://doi.org/10.3109/13685538.2013.772134 2023-02-01T23:29:22Z Abstract Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if low circulating testosterone or E2 levels in combination with variants in the estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) genes were of importance for the risk of type-2 diabetes. The single nucleotide polymorphisms rs2207396 and rs1256049, in ESR1 and ESR2, respectively, were analysed by allele specific PCR in 172 elderly men from the population-based Tromsø study. The results were adjusted for age. In individuals with low total (≤11 nmol/L) or free testosterone (≤0.18 nmol/L) being carriers of the variant A-allele in ESR1 was associated with 7.3 and 15.9 times, respectively, increased odds ratio of being diagnosed with diabetes mellitus type 2 (p = 0.025 and p = 0.018, respectively). Lower concentrations of E2 did not seem to increase the risk of being diagnosed with diabetes. In conclusion, in hypogonadal men, the rs2207396 variant in ESR1 predicts the risk of type 2 diabetes. Article in Journal/Newspaper Tromsø Lund University Publications (LUP) Tromsø The Aging Male 16 2 52 57 |
institution |
Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Obstetrics Gynecology and Reproductive Medicine |
spellingShingle |
Obstetrics Gynecology and Reproductive Medicine Linnér, Carl Svartberg, Johan Giwercman, Aleksander Giwercman, Yvonne Lundberg Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
topic_facet |
Obstetrics Gynecology and Reproductive Medicine |
description |
Abstract Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if low circulating testosterone or E2 levels in combination with variants in the estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) genes were of importance for the risk of type-2 diabetes. The single nucleotide polymorphisms rs2207396 and rs1256049, in ESR1 and ESR2, respectively, were analysed by allele specific PCR in 172 elderly men from the population-based Tromsø study. The results were adjusted for age. In individuals with low total (≤11 nmol/L) or free testosterone (≤0.18 nmol/L) being carriers of the variant A-allele in ESR1 was associated with 7.3 and 15.9 times, respectively, increased odds ratio of being diagnosed with diabetes mellitus type 2 (p = 0.025 and p = 0.018, respectively). Lower concentrations of E2 did not seem to increase the risk of being diagnosed with diabetes. In conclusion, in hypogonadal men, the rs2207396 variant in ESR1 predicts the risk of type 2 diabetes. |
format |
Article in Journal/Newspaper |
author |
Linnér, Carl Svartberg, Johan Giwercman, Aleksander Giwercman, Yvonne Lundberg |
author_facet |
Linnér, Carl Svartberg, Johan Giwercman, Aleksander Giwercman, Yvonne Lundberg |
author_sort |
Linnér, Carl |
title |
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
title_short |
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
title_full |
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
title_fullStr |
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
title_full_unstemmed |
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
title_sort |
estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. |
publisher |
Informa Healthcare |
publishDate |
2013 |
url |
https://lup.lub.lu.se/record/3628034 https://doi.org/10.3109/13685538.2013.772134 https://portal.research.lu.se/files/1543792/3910622.pdf |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
The Aging Male; 16(2), pp 52-57 (2013) ISSN: 1473-0790 |
op_relation |
https://lup.lub.lu.se/record/3628034 http://dx.doi.org/10.3109/13685538.2013.772134 https://portal.research.lu.se/files/1543792/3910622.pdf wos:000319129900005 pmid:23506158 scopus:84877935394 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3109/13685538.2013.772134 |
container_title |
The Aging Male |
container_volume |
16 |
container_issue |
2 |
container_start_page |
52 |
op_container_end_page |
57 |
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1766219514604683264 |