Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. METHODS: Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukrain...
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Main Authors: | , , , , , , , , , , , , , |
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Language: | English |
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BioMed Central (BMC)
2005
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Online Access: | https://lup.lub.lu.se/record/1132113 https://doi.org/10.1186/1476-069X-4-26 |
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ftulundlup:oai:lup.lub.lu.se:edbe63fa-8d77-4121-a2c4-929171111bfd 2023-05-15T16:29:58+02:00 Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter 2005 https://lup.lub.lu.se/record/1132113 https://doi.org/10.1186/1476-069X-4-26 eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/1132113 http://dx.doi.org/10.1186/1476-069X-4-26 pmid:16280075 scopus:28844489678 Environmental Health; 4(26) (2005) ISSN: 1476-069X Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2005 ftulundlup https://doi.org/10.1186/1476-069X-4-26 2023-02-01T23:28:19Z BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. METHODS: Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and Greenland were consecutively enrolled during antenatal visits. Swedish fishermen and their spouses were recruited separately and independently of current pregnancy. Lipid adjusted serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to pregnancy interviews were obtained among 2269 women and 798 men provided a semen sample. RESULTS: Inuits had high levels of both POP markers, Swedish fishermen were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5-0.8)] and elevated in Swedish fishermen families [FR 1.26 (95% CI 1.0-1.6)]. Adjusted geometric means of sperm counts and morphology did not differ between regions while sperm motility was higher in men living in Warsaw. CONCLUSION: We observed regional differences in time to pregnancy and sperm motility that may be related to regional differences in POP blood levels, but other interpretations are also plausible. In particular, differences in access to safe contraception and in the prevalence of contraceptive failures are most likely to bias comparisons of time to pregnancy. Article in Journal/Newspaper Greenland inuits Lund University Publications (LUP) Greenland Environmental Health 4 1 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
topic_facet |
Environmental Health and Occupational Health |
description |
BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. METHODS: Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and Greenland were consecutively enrolled during antenatal visits. Swedish fishermen and their spouses were recruited separately and independently of current pregnancy. Lipid adjusted serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to pregnancy interviews were obtained among 2269 women and 798 men provided a semen sample. RESULTS: Inuits had high levels of both POP markers, Swedish fishermen were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5-0.8)] and elevated in Swedish fishermen families [FR 1.26 (95% CI 1.0-1.6)]. Adjusted geometric means of sperm counts and morphology did not differ between regions while sperm motility was higher in men living in Warsaw. CONCLUSION: We observed regional differences in time to pregnancy and sperm motility that may be related to regional differences in POP blood levels, but other interpretations are also plausible. In particular, differences in access to safe contraception and in the prevalence of contraceptive failures are most likely to bias comparisons of time to pregnancy. |
format |
Article in Journal/Newspaper |
author |
Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter |
author_facet |
Toft, Gunnar Axmon, Anna Giwercman, Aleksander Thulstrup, Ane Marie Rignell-Hydbom, Anna Pedersen, Henning Sloth Ludwicki, Jan K Zvyezday, Valentina Zinchuk, Andery Spano, Marcello Manicardi, Gian Carlo Bonefeld-Jørgensen, Eva C Hagmar, Lars Bonde, Jens Peter |
author_sort |
Toft, Gunnar |
title |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_short |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_full |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_fullStr |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_full_unstemmed |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
title_sort |
fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
publisher |
BioMed Central (BMC) |
publishDate |
2005 |
url |
https://lup.lub.lu.se/record/1132113 https://doi.org/10.1186/1476-069X-4-26 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuits |
genre_facet |
Greenland inuits |
op_source |
Environmental Health; 4(26) (2005) ISSN: 1476-069X |
op_relation |
https://lup.lub.lu.se/record/1132113 http://dx.doi.org/10.1186/1476-069X-4-26 pmid:16280075 scopus:28844489678 |
op_doi |
https://doi.org/10.1186/1476-069X-4-26 |
container_title |
Environmental Health |
container_volume |
4 |
container_issue |
1 |
_version_ |
1766019677184589824 |