Markers of high fish intake are associated with decreased risk of a first myocardial infarction

• Published in: British Journal of Nutrition
• Main Authors: Hallgren, C G, Hallmans, G, Jansson, J H, Marklund, S L, Huhtasaari, F, Schutz, A, Strömberg, Ulf, Vessby, B, Skerfving, Staffan
• Format: Article in Journal/Newspaper
• Language: English
• Published: Cambridge University Press 2001
• Subjects: Nutrition and Dietetics; Fish intake; Mercury; n-3 polyunsaturated fatty acids; Myocardial infarction; Northern Sweden
• Online Access: https://lup.lub.lu.se/record/1121696; https://doi.org/10.1079/BJN2001415

High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors.