Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway

• Published in: Reproductive Toxicology
• Main Authors: Haugen, Trine B., Tefre, Toril, Malm, Gunilla, Jönsson, Bo A, Rylander, Lars, Hagmar, Lars, Bjorsvik, Cathrine, Henrichsen, Trine, Saether, Thomas, Figenschau, Yngve, Giwercman, Aleksander
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2011
• Subjects: Obstetrics; Gynecology and Reproductive Medicine; Reproductive hormones; Sperm characteristics; POPs; CB-153; p '-DDE; p; Norway; Geographical difference; Male; Arctic
• Online Access: https://lup.lub.lu.se/record/2253031; https://doi.org/10.1016/j.reprotox.2011.06.072

Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p = 0.27) or sperm parameters. However, the levels of AV-ODE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p = 0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong relationship between the CB-153 and the SHBG levels was observed. The regional differences observed for p,p'-DDE, testosterone and FSH were not reflected in the semen quality. (C) 2011 Elsevier Inc. All rights reserved.