Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries
PURPOSE: To assess the risk of death in patients who survive more than 5 years after diagnosis of childhood cancer and to evaluate causes of death in fatal cases. PATIENTS AND METHODS: This was a population-based study in the five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) usin...
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American Society of Clinical Oncology
2001
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ftulundlup:oai:lup.lub.lu.se:e61db290-81be-4673-acd7-b1239f9343f6 2023-05-15T16:51:42+02:00 Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries Möller, Torgil R. Garwicz, Stanislaw Barlow, Lotti Falck Winther, Jeanette Glattre, Eystein Olafsdottir, Gudridur Olsen, Jörgen H. Perfekt, Roland Ritvanen, Annukka Sankila, Risto Tulinius, Hrafn 2001 https://lup.lub.lu.se/record/1120585 eng eng American Society of Clinical Oncology https://lup.lub.lu.se/record/1120585 pmid:11432883 scopus:0035398565 Journal of Clinical Oncology; 19(13), pp 3173-3181 (2001) ISSN: 1527-7755 Cancer and Oncology contributiontojournal/article info:eu-repo/semantics/article text 2001 ftulundlup 2023-02-01T23:28:28Z PURPOSE: To assess the risk of death in patients who survive more than 5 years after diagnosis of childhood cancer and to evaluate causes of death in fatal cases. PATIENTS AND METHODS: This was a population-based study in the five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) using data of the nationwide cancer registries and the cause-of-death registries. The study cohort included 13,711 patients who were diagnosed with cancer before the age of 20 years between 1960 and 1989 and who survived at least 5 years from diagnosis. By December 31, 1995, 1,422 patients had died, and death certificates were assessed in 1,402. Standardized mortality ratios (SMRs) for validated causes of death were calculated based on 156,046 patient-years at risk. RESULTS: The overall SMR was 10.8 (95% confidence interval [CI], 10.3 to 11.5), mainly due to high excess mortality from the primary cancer. SMR for second cancer was 4.9 (95% CI, 3.9 to 5.9) and was 3.1 (95% CI, 2.8 to 3.5) for noncancer death. The pattern of causes of death varied markedly between different groups of primary cancer diagnoses and was highly dependent on time passed since diagnosis. Overall late mortality was significantly lower in patients treated during the most recent period of time, 1980 to 1989, compared with those treated from 1960 to 1979 (hazard ratio, 0.61; 95% CI, 0.54 to 0.70), and there was no increase in rates of death due to cancer treatment. CONCLUSION: Long-term survivors of childhood cancer had an increased mortality rate, mainly dying from primary cancers. However, modern treatments have reduced late cancer mortality without increasing the rate of therapy-related deaths. Article in Journal/Newspaper Iceland Lund University Publications (LUP) Norway |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology |
spellingShingle |
Cancer and Oncology Möller, Torgil R. Garwicz, Stanislaw Barlow, Lotti Falck Winther, Jeanette Glattre, Eystein Olafsdottir, Gudridur Olsen, Jörgen H. Perfekt, Roland Ritvanen, Annukka Sankila, Risto Tulinius, Hrafn Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries |
topic_facet |
Cancer and Oncology |
description |
PURPOSE: To assess the risk of death in patients who survive more than 5 years after diagnosis of childhood cancer and to evaluate causes of death in fatal cases. PATIENTS AND METHODS: This was a population-based study in the five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) using data of the nationwide cancer registries and the cause-of-death registries. The study cohort included 13,711 patients who were diagnosed with cancer before the age of 20 years between 1960 and 1989 and who survived at least 5 years from diagnosis. By December 31, 1995, 1,422 patients had died, and death certificates were assessed in 1,402. Standardized mortality ratios (SMRs) for validated causes of death were calculated based on 156,046 patient-years at risk. RESULTS: The overall SMR was 10.8 (95% confidence interval [CI], 10.3 to 11.5), mainly due to high excess mortality from the primary cancer. SMR for second cancer was 4.9 (95% CI, 3.9 to 5.9) and was 3.1 (95% CI, 2.8 to 3.5) for noncancer death. The pattern of causes of death varied markedly between different groups of primary cancer diagnoses and was highly dependent on time passed since diagnosis. Overall late mortality was significantly lower in patients treated during the most recent period of time, 1980 to 1989, compared with those treated from 1960 to 1979 (hazard ratio, 0.61; 95% CI, 0.54 to 0.70), and there was no increase in rates of death due to cancer treatment. CONCLUSION: Long-term survivors of childhood cancer had an increased mortality rate, mainly dying from primary cancers. However, modern treatments have reduced late cancer mortality without increasing the rate of therapy-related deaths. |
format |
Article in Journal/Newspaper |
author |
Möller, Torgil R. Garwicz, Stanislaw Barlow, Lotti Falck Winther, Jeanette Glattre, Eystein Olafsdottir, Gudridur Olsen, Jörgen H. Perfekt, Roland Ritvanen, Annukka Sankila, Risto Tulinius, Hrafn |
author_facet |
Möller, Torgil R. Garwicz, Stanislaw Barlow, Lotti Falck Winther, Jeanette Glattre, Eystein Olafsdottir, Gudridur Olsen, Jörgen H. Perfekt, Roland Ritvanen, Annukka Sankila, Risto Tulinius, Hrafn |
author_sort |
Möller, Torgil R. |
title |
Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries |
title_short |
Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries |
title_full |
Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries |
title_fullStr |
Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries |
title_full_unstemmed |
Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries |
title_sort |
decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the nordic countries |
publisher |
American Society of Clinical Oncology |
publishDate |
2001 |
url |
https://lup.lub.lu.se/record/1120585 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Clinical Oncology; 19(13), pp 3173-3181 (2001) ISSN: 1527-7755 |
op_relation |
https://lup.lub.lu.se/record/1120585 pmid:11432883 scopus:0035398565 |
_version_ |
1766041806765555712 |