Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine
Background: Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning...
Published in: | Environmental Health |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BioMed Central (BMC)
2014
|
Subjects: | |
Online Access: | https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3 https://doi.org/10.1186/1476-069X-13-116 |
id |
ftulundlup:oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3 |
---|---|
record_format |
openpolar |
spelling |
ftulundlup:oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3 2024-04-28T08:20:57+00:00 Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine Jørgensen, Kristian T. Specht, Ina O. Lenters, Virissa Bach, Cathrine C. Rylander, Lars Jönsson, Bo A.G. Lindh, Christian H. Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens Peter 2014-12-22 https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3 https://doi.org/10.1186/1476-069X-13-116 eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3 http://dx.doi.org/10.1186/1476-069X-13-116 scopus:84926474797 pmid:25533644 Environmental Health: A Global Access Science Source; 13(1), no 116 (2014) ISSN: 1476-069X Obstetrics Gynecology and Reproductive Medicine Fecundity Infertility Perfluorinated compounds Persistent environmental pollutants contributiontojournal/article info:eu-repo/semantics/article text 2014 ftulundlup https://doi.org/10.1186/1476-069X-13-116 2024-04-03T14:03:10Z Background: Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods: We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results: Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR∈=∈0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR∈=∈0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR∈=∈1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR∈=∈1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions: Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Environmental Health 13 1 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Obstetrics Gynecology and Reproductive Medicine Fecundity Infertility Perfluorinated compounds Persistent environmental pollutants |
spellingShingle |
Obstetrics Gynecology and Reproductive Medicine Fecundity Infertility Perfluorinated compounds Persistent environmental pollutants Jørgensen, Kristian T. Specht, Ina O. Lenters, Virissa Bach, Cathrine C. Rylander, Lars Jönsson, Bo A.G. Lindh, Christian H. Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens Peter Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
topic_facet |
Obstetrics Gynecology and Reproductive Medicine Fecundity Infertility Perfluorinated compounds Persistent environmental pollutants |
description |
Background: Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods: We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results: Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR∈=∈0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR∈=∈0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR∈=∈1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR∈=∈1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions: Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive. |
format |
Article in Journal/Newspaper |
author |
Jørgensen, Kristian T. Specht, Ina O. Lenters, Virissa Bach, Cathrine C. Rylander, Lars Jönsson, Bo A.G. Lindh, Christian H. Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens Peter |
author_facet |
Jørgensen, Kristian T. Specht, Ina O. Lenters, Virissa Bach, Cathrine C. Rylander, Lars Jönsson, Bo A.G. Lindh, Christian H. Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens Peter |
author_sort |
Jørgensen, Kristian T. |
title |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_short |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_full |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_fullStr |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_full_unstemmed |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_sort |
perfluoroalkyl substances and time to pregnancy in couples from greenland, poland and ukraine |
publisher |
BioMed Central (BMC) |
publishDate |
2014 |
url |
https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3 https://doi.org/10.1186/1476-069X-13-116 |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Environmental Health: A Global Access Science Source; 13(1), no 116 (2014) ISSN: 1476-069X |
op_relation |
https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3 http://dx.doi.org/10.1186/1476-069X-13-116 scopus:84926474797 pmid:25533644 |
op_doi |
https://doi.org/10.1186/1476-069X-13-116 |
container_title |
Environmental Health |
container_volume |
13 |
container_issue |
1 |
_version_ |
1797583555929309184 |