No Risk of Maternal EBV Infection for Childhood Leukemia.
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnose...
Published in: | Cancer Epidemiology Biomarkers & Prevention |
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American Association for Cancer Research
2009
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Online Access: | https://lup.lub.lu.se/record/1483454 https://doi.org/10.1158/1055-9965.EPI-09-0751 |
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ftulundlup:oai:lup.lub.lu.se:db15e431-e8c2-4c1a-bcfa-42620a6e4357 2023-05-15T16:50:21+02:00 No Risk of Maternal EBV Infection for Childhood Leukemia. Tedeschi, Rosamaria Luostarinen, Tapio Marus, Alessia Bzhalava, Davit Ogmundsdottir, Helga M Dillner, Joakim De Paoli, Paolo Surcel, Heljä-Marja Pukkala, Eero Lehtinen, Matti Lehtinen, Tuula 2009 https://lup.lub.lu.se/record/1483454 https://doi.org/10.1158/1055-9965.EPI-09-0751 eng eng American Association for Cancer Research https://lup.lub.lu.se/record/1483454 http://dx.doi.org/10.1158/1055-9965.EPI-09-0751 wos:000270702100030 pmid:19755652 scopus:70350103717 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology; 18, pp 2790-2792 (2009) ISSN: 1538-7755 Cancer and Oncology contributiontojournal/article info:eu-repo/semantics/article text 2009 ftulundlup https://doi.org/10.1158/1055-9965.EPI-09-0751 2023-02-01T23:30:10Z We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified through national cancer registries. For each index mother of a leukemia case, three matched control mothers with cancer-free offspring were identified. First trimester sera from 561 ALL and 144 non-ALL index mothers and from 2,105 control mothers were analyzed for antibodies to EBV viral capsid antigen (IgG and IgM), early antigen (IgG) and ZEBRA protein (IgG). Conditional logistic regression-based estimates of odds ratios and 95% confidence intervals adjusted for birth order and sib-ship size were calculated. Overall, there was no evidence of increased risk of ALL associated to EBV viral capsid antigen IgM (odds ratio, 0.9; 95% confidence interval, 0.5-1.8). The early antigen and ZEBRA antibodies (EBV reactivation markers) were also not associated with risk. The data argue against a role of EBV in ALL. (Cancer Epidemiol Biomarkers Prev 2009;18(10):OF1-3). Article in Journal/Newspaper Iceland Lund University Publications (LUP) Cancer Epidemiology Biomarkers & Prevention 18 10 2790 2792 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology |
spellingShingle |
Cancer and Oncology Tedeschi, Rosamaria Luostarinen, Tapio Marus, Alessia Bzhalava, Davit Ogmundsdottir, Helga M Dillner, Joakim De Paoli, Paolo Surcel, Heljä-Marja Pukkala, Eero Lehtinen, Matti Lehtinen, Tuula No Risk of Maternal EBV Infection for Childhood Leukemia. |
topic_facet |
Cancer and Oncology |
description |
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified through national cancer registries. For each index mother of a leukemia case, three matched control mothers with cancer-free offspring were identified. First trimester sera from 561 ALL and 144 non-ALL index mothers and from 2,105 control mothers were analyzed for antibodies to EBV viral capsid antigen (IgG and IgM), early antigen (IgG) and ZEBRA protein (IgG). Conditional logistic regression-based estimates of odds ratios and 95% confidence intervals adjusted for birth order and sib-ship size were calculated. Overall, there was no evidence of increased risk of ALL associated to EBV viral capsid antigen IgM (odds ratio, 0.9; 95% confidence interval, 0.5-1.8). The early antigen and ZEBRA antibodies (EBV reactivation markers) were also not associated with risk. The data argue against a role of EBV in ALL. (Cancer Epidemiol Biomarkers Prev 2009;18(10):OF1-3). |
format |
Article in Journal/Newspaper |
author |
Tedeschi, Rosamaria Luostarinen, Tapio Marus, Alessia Bzhalava, Davit Ogmundsdottir, Helga M Dillner, Joakim De Paoli, Paolo Surcel, Heljä-Marja Pukkala, Eero Lehtinen, Matti Lehtinen, Tuula |
author_facet |
Tedeschi, Rosamaria Luostarinen, Tapio Marus, Alessia Bzhalava, Davit Ogmundsdottir, Helga M Dillner, Joakim De Paoli, Paolo Surcel, Heljä-Marja Pukkala, Eero Lehtinen, Matti Lehtinen, Tuula |
author_sort |
Tedeschi, Rosamaria |
title |
No Risk of Maternal EBV Infection for Childhood Leukemia. |
title_short |
No Risk of Maternal EBV Infection for Childhood Leukemia. |
title_full |
No Risk of Maternal EBV Infection for Childhood Leukemia. |
title_fullStr |
No Risk of Maternal EBV Infection for Childhood Leukemia. |
title_full_unstemmed |
No Risk of Maternal EBV Infection for Childhood Leukemia. |
title_sort |
no risk of maternal ebv infection for childhood leukemia. |
publisher |
American Association for Cancer Research |
publishDate |
2009 |
url |
https://lup.lub.lu.se/record/1483454 https://doi.org/10.1158/1055-9965.EPI-09-0751 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology; 18, pp 2790-2792 (2009) ISSN: 1538-7755 |
op_relation |
https://lup.lub.lu.se/record/1483454 http://dx.doi.org/10.1158/1055-9965.EPI-09-0751 wos:000270702100030 pmid:19755652 scopus:70350103717 |
op_doi |
https://doi.org/10.1158/1055-9965.EPI-09-0751 |
container_title |
Cancer Epidemiology Biomarkers & Prevention |
container_volume |
18 |
container_issue |
10 |
container_start_page |
2790 |
op_container_end_page |
2792 |
_version_ |
1766040515512369152 |