Environmental Hexachlorobenzene exposure and human male reproductive function.
Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled...
Published in: | Reproductive Toxicology |
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Format: | Article in Journal/Newspaper |
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2015
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Online Access: | https://lup.lub.lu.se/record/7720745 https://doi.org/10.1016/j.reprotox.2015.07.074 |
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ftulundlup:oai:lup.lub.lu.se:d8281c44-01f2-4bea-94c8-3ea79bd5ecd4 2023-05-15T16:27:26+02:00 Environmental Hexachlorobenzene exposure and human male reproductive function. Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Jönsson, Bo A Robbins, Wendie A 2015 https://lup.lub.lu.se/record/7720745 https://doi.org/10.1016/j.reprotox.2015.07.074 eng eng Elsevier https://lup.lub.lu.se/record/7720745 http://dx.doi.org/10.1016/j.reprotox.2015.07.074 pmid:26210665 wos:000367559600002 scopus:84939213235 Reproductive Toxicology; 58(Jul 22), pp 8-14 (2015) ISSN: 1873-1708 Environmental Health and Occupational Health Obstetrics Gynecology and Reproductive Medicine contributiontojournal/article info:eu-repo/semantics/article text 2015 ftulundlup https://doi.org/10.1016/j.reprotox.2015.07.074 2023-02-01T23:28:52Z Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3 ng/g lipid) and Greenland (79.0 ng/g lipid) compared to Poland (14.2 ng/g lipid). Sex Hormone Binding Globulin (SHBG) and Free Androgen Index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population. Article in Journal/Newspaper Greenland inuit Lund University Publications (LUP) Greenland Reproductive Toxicology 58 8 14 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Obstetrics Gynecology and Reproductive Medicine |
spellingShingle |
Environmental Health and Occupational Health Obstetrics Gynecology and Reproductive Medicine Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Jönsson, Bo A Robbins, Wendie A Environmental Hexachlorobenzene exposure and human male reproductive function. |
topic_facet |
Environmental Health and Occupational Health Obstetrics Gynecology and Reproductive Medicine |
description |
Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3 ng/g lipid) and Greenland (79.0 ng/g lipid) compared to Poland (14.2 ng/g lipid). Sex Hormone Binding Globulin (SHBG) and Free Androgen Index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population. |
format |
Article in Journal/Newspaper |
author |
Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Jönsson, Bo A Robbins, Wendie A |
author_facet |
Specht, Ina Olmer Bonde, Jens Peter Ellekilde Toft, Gunnar Giwercman, Aleksander Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Jönsson, Bo A Robbins, Wendie A |
author_sort |
Specht, Ina Olmer |
title |
Environmental Hexachlorobenzene exposure and human male reproductive function. |
title_short |
Environmental Hexachlorobenzene exposure and human male reproductive function. |
title_full |
Environmental Hexachlorobenzene exposure and human male reproductive function. |
title_fullStr |
Environmental Hexachlorobenzene exposure and human male reproductive function. |
title_full_unstemmed |
Environmental Hexachlorobenzene exposure and human male reproductive function. |
title_sort |
environmental hexachlorobenzene exposure and human male reproductive function. |
publisher |
Elsevier |
publishDate |
2015 |
url |
https://lup.lub.lu.se/record/7720745 https://doi.org/10.1016/j.reprotox.2015.07.074 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Reproductive Toxicology; 58(Jul 22), pp 8-14 (2015) ISSN: 1873-1708 |
op_relation |
https://lup.lub.lu.se/record/7720745 http://dx.doi.org/10.1016/j.reprotox.2015.07.074 pmid:26210665 wos:000367559600002 scopus:84939213235 |
op_doi |
https://doi.org/10.1016/j.reprotox.2015.07.074 |
container_title |
Reproductive Toxicology |
container_volume |
58 |
container_start_page |
8 |
op_container_end_page |
14 |
_version_ |
1766016620574015488 |