Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to assoc...
Published in: | Nature Genetics |
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Online Access: | https://lup.lub.lu.se/record/1677884 https://doi.org/10.1038/ng.622 |
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ftulundlup:oai:lup.lub.lu.se:d7ad61fd-a9d2-4d5f-91f9-0c0fd8eedd89 2023-05-15T16:49:55+02:00 Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. 2010 https://lup.lub.lu.se/record/1677884 https://doi.org/10.1038/ng.622 eng eng Nature Publishing Group https://lup.lub.lu.se/record/1677884 http://dx.doi.org/10.1038/ng.622 wos:000280524000014 scopus:84947899513 pmid:20622881 Nature Genetics; 42(8), pp 71-692 (2010) ISSN: 1546-1718 Cardiac and Cardiovascular Systems contributiontojournal/article info:eu-repo/semantics/article text 2010 ftulundlup https://doi.org/10.1038/ng.622 2023-02-01T23:32:41Z We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. Article in Journal/Newspaper Iceland Lund University Publications (LUP) Nature Genetics 42 8 692 697 |
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English |
topic |
Cardiac and Cardiovascular Systems |
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Cardiac and Cardiovascular Systems Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
topic_facet |
Cardiac and Cardiovascular Systems |
description |
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. |
format |
Article in Journal/Newspaper |
author |
Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. |
author_facet |
Gretarsdottir, Solveig Baas, Annette F. Thorleifsson, Gudmar Holm, Hilma den Heijer, Martin de Vries, Jean-Paul P. M. Kranendonk, Steef E. Zeebregts, Clark J. A. M. van Sterkenburg, Steven M. Geelkerken, Robert H. van Rij, Andre M. Williams, Michael J. A. Boll, Albert P. M. Kostic, Jelena P. Jonasdottir, Adalbjorg Jonasdottir, Aslaug Walters, G. Bragi Masson, Gisli Sulem, Patrick Saemundsdottir, Jona Mouy, Magali Magnusson, Kristinn P. Tromp, Gerard Elmore, James R. Sakalihasan, Natzi Limet, Raymond Defraigne, Jean-Olivier Ferrell, Robert E. Ronkainen, Antti Ruigrok, Ynte M. Wijmenga, Cisca Grobbee, Diederick E. Shah, Svati H. Granger, Christopher B. Quyyumi, Arshed A. Vaccarino, Viola Patel, Riyaz S. Zafari, A. Maziar Levey, Allan I. Austin, Harland Girelli, Domenico Pignatti, Pier Franco Olivieri, Oliviero Martinelli, Nicola Malerba, Giovanni Trabetti, Elisabetta Becker, Lewis C. Becker, Diane M. Reilly, Muredach P. Rader, Daniel J. |
author_sort |
Gretarsdottir, Solveig |
title |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_short |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_full |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_fullStr |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_full_unstemmed |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
title_sort |
genome-wide association study identifies a sequence variant within the dab2ip gene conferring susceptibility to abdominal aortic aneurysm |
publisher |
Nature Publishing Group |
publishDate |
2010 |
url |
https://lup.lub.lu.se/record/1677884 https://doi.org/10.1038/ng.622 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Nature Genetics; 42(8), pp 71-692 (2010) ISSN: 1546-1718 |
op_relation |
https://lup.lub.lu.se/record/1677884 http://dx.doi.org/10.1038/ng.622 wos:000280524000014 scopus:84947899513 pmid:20622881 |
op_doi |
https://doi.org/10.1038/ng.622 |
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Nature Genetics |
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