Cadmium, copper and zinc in tissues of deceased copper smelter workers
Workers at a copper and lead smelter in northern Sweden have a multifactorial exposure to a number of heavy metals. The concentrations of cadmium, copper and zinc in Liver, Lung, kidney and brain tissues have been deters mined by atomic absorption spectrometry in 32 deceased tong-term exposed male l...
Published in: | Journal of Trace Elements in Medicine and Biology |
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Online Access: | https://lup.lub.lu.se/record/319760 https://doi.org/10.1016/S0946-672X(02)80055-4 |
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ftulundlup:oai:lup.lub.lu.se:d190c9f6-9f03-4d12-9b7a-1ee3b81fbdbc 2023-05-15T17:45:11+02:00 Cadmium, copper and zinc in tissues of deceased copper smelter workers Gerhardsson, Lars Englyst, V Lundstrom, NG Sandberg, S Nordberg, G 2002 https://lup.lub.lu.se/record/319760 https://doi.org/10.1016/S0946-672X(02)80055-4 eng eng Elsevier https://lup.lub.lu.se/record/319760 http://dx.doi.org/10.1016/S0946-672X(02)80055-4 wos:000180299800010 pmid:12530590 scopus:12244267043 Journal of Trace Elements in Medicine and Biology; 16(4), pp 261-266 (2002) ISSN: 1878-3252 Environmental Health and Occupational Health biological monitoring nails hair soft tissues zinc copper smelter workers cadmium contributiontojournal/article info:eu-repo/semantics/article text 2002 ftulundlup https://doi.org/10.1016/S0946-672X(02)80055-4 2023-02-01T23:32:35Z Workers at a copper and lead smelter in northern Sweden have a multifactorial exposure to a number of heavy metals. The concentrations of cadmium, copper and zinc in Liver, Lung, kidney and brain tissues have been deters mined by atomic absorption spectrometry in 32 deceased tong-term exposed male lead smelter workers, and compared with those of 10 male controls. Furthermore, copper and zinc Levels in hair and nails were determined by energy-dispersive X-ray fluorescence. The highest cadmium concentrations among both workers and controls were observed in kidney, followed in order by liver, lung and brain. The levels in kidney, Liver and Lung were all significantly higher in the workers than in the controls (p < 0.03). Among the workers relatively strong positive correlations (p < 0.03) were observed between cadmium concentrations in liver and lung, liver and kidney, liver and brain, and lung and brain. In the exposed workers a positive correlation was observed between cadmium and zinc concentrations in the kidney (r(s) = 0.38; p = 0.034). This is probably mainly due to the protein metallothionein, which is stored in the kidney, binding equimolar amounts of these two metals. The highest concentrations of copper were found in hair and nails among both workers and controls, followed in order by liver, brain, kidney and Lung. The tissue concentrations of copper in brain, Lung and kidney were all significantly higher among the smelter workers than in the controls (p less than or equal to 0.036). Copper Levels in lung and age at time of death were positively correlated among the exposed workers (r(s) = 0.39; p = 0.029). In the same group, positive correlations between copper and zinc concentrations in kidney (r(s) = 0.45; p = 0.009) and nails (r(s) = 0.68; p < 0.001) were also observed, reflecting possible biological interactions between these two metals. Among both workers and controls, the highest zinc concentrations were found in hair, followed in order by nails, liver, kidney, brain and lung. ... Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Journal of Trace Elements in Medicine and Biology 16 4 261 266 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health biological monitoring nails hair soft tissues zinc copper smelter workers cadmium |
spellingShingle |
Environmental Health and Occupational Health biological monitoring nails hair soft tissues zinc copper smelter workers cadmium Gerhardsson, Lars Englyst, V Lundstrom, NG Sandberg, S Nordberg, G Cadmium, copper and zinc in tissues of deceased copper smelter workers |
topic_facet |
Environmental Health and Occupational Health biological monitoring nails hair soft tissues zinc copper smelter workers cadmium |
description |
Workers at a copper and lead smelter in northern Sweden have a multifactorial exposure to a number of heavy metals. The concentrations of cadmium, copper and zinc in Liver, Lung, kidney and brain tissues have been deters mined by atomic absorption spectrometry in 32 deceased tong-term exposed male lead smelter workers, and compared with those of 10 male controls. Furthermore, copper and zinc Levels in hair and nails were determined by energy-dispersive X-ray fluorescence. The highest cadmium concentrations among both workers and controls were observed in kidney, followed in order by liver, lung and brain. The levels in kidney, Liver and Lung were all significantly higher in the workers than in the controls (p < 0.03). Among the workers relatively strong positive correlations (p < 0.03) were observed between cadmium concentrations in liver and lung, liver and kidney, liver and brain, and lung and brain. In the exposed workers a positive correlation was observed between cadmium and zinc concentrations in the kidney (r(s) = 0.38; p = 0.034). This is probably mainly due to the protein metallothionein, which is stored in the kidney, binding equimolar amounts of these two metals. The highest concentrations of copper were found in hair and nails among both workers and controls, followed in order by liver, brain, kidney and Lung. The tissue concentrations of copper in brain, Lung and kidney were all significantly higher among the smelter workers than in the controls (p less than or equal to 0.036). Copper Levels in lung and age at time of death were positively correlated among the exposed workers (r(s) = 0.39; p = 0.029). In the same group, positive correlations between copper and zinc concentrations in kidney (r(s) = 0.45; p = 0.009) and nails (r(s) = 0.68; p < 0.001) were also observed, reflecting possible biological interactions between these two metals. Among both workers and controls, the highest zinc concentrations were found in hair, followed in order by nails, liver, kidney, brain and lung. ... |
format |
Article in Journal/Newspaper |
author |
Gerhardsson, Lars Englyst, V Lundstrom, NG Sandberg, S Nordberg, G |
author_facet |
Gerhardsson, Lars Englyst, V Lundstrom, NG Sandberg, S Nordberg, G |
author_sort |
Gerhardsson, Lars |
title |
Cadmium, copper and zinc in tissues of deceased copper smelter workers |
title_short |
Cadmium, copper and zinc in tissues of deceased copper smelter workers |
title_full |
Cadmium, copper and zinc in tissues of deceased copper smelter workers |
title_fullStr |
Cadmium, copper and zinc in tissues of deceased copper smelter workers |
title_full_unstemmed |
Cadmium, copper and zinc in tissues of deceased copper smelter workers |
title_sort |
cadmium, copper and zinc in tissues of deceased copper smelter workers |
publisher |
Elsevier |
publishDate |
2002 |
url |
https://lup.lub.lu.se/record/319760 https://doi.org/10.1016/S0946-672X(02)80055-4 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Trace Elements in Medicine and Biology; 16(4), pp 261-266 (2002) ISSN: 1878-3252 |
op_relation |
https://lup.lub.lu.se/record/319760 http://dx.doi.org/10.1016/S0946-672X(02)80055-4 wos:000180299800010 pmid:12530590 scopus:12244267043 |
op_doi |
https://doi.org/10.1016/S0946-672X(02)80055-4 |
container_title |
Journal of Trace Elements in Medicine and Biology |
container_volume |
16 |
container_issue |
4 |
container_start_page |
261 |
op_container_end_page |
266 |
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1766147999104237568 |