Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression
Background: Some legacy and emerging environmental contaminants are suspected risk factors for intrauterine growth restriction. However, the evidence is equivocal, in part due to difficulties in disentangling the effects of mixtures. Objectives: We assessed associations between multiple correlated b...
Published in: | Environmental Health Perspectives |
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National Institute of Environmental Health Sciences
2016
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Online Access: | https://lup.lub.lu.se/record/d081002e-5e4d-4b41-8878-479595208e17 https://doi.org/10.1289/ehp.1408933 |
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ftulundlup:oai:lup.lub.lu.se:d081002e-5e4d-4b41-8878-479595208e17 2024-05-19T07:41:25+00:00 Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression Lenters, Virissa Portengen, Lützen Rignell-Hydbom, Anna Jönsson, Bo A G Lindh, Christian H. Piersma, Aldert H. Toft, Gunnar Bonde, Jens Peter Heederik, Dick Rylander, Lars Vermeulen, Roel 2016-03-01 https://lup.lub.lu.se/record/d081002e-5e4d-4b41-8878-479595208e17 https://doi.org/10.1289/ehp.1408933 eng eng National Institute of Environmental Health Sciences https://lup.lub.lu.se/record/d081002e-5e4d-4b41-8878-479595208e17 http://dx.doi.org/10.1289/ehp.1408933 scopus:84959308178 wos:000371442500024 pmid:26115335 Environmental Health Perspectives; 124(3), pp 365-372 (2016) ISSN: 0091-6765 Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2016 ftulundlup https://doi.org/10.1289/ehp.1408933 2024-04-23T23:34:34Z Background: Some legacy and emerging environmental contaminants are suspected risk factors for intrauterine growth restriction. However, the evidence is equivocal, in part due to difficulties in disentangling the effects of mixtures. Objectives: We assessed associations between multiple correlated biomarkers of environmental exposure and birth weight. Methods: We evaluated a cohort of 1,250 term (≥ 37 weeks gestation) singleton infants, born to 513 mothers from Greenland, 180 from Poland, and 557 from Ukraine, who were recruited during antenatal care visits in 2002‒2004. Secondary metabolites of diethylhexyl and diisononyl phthalates (DEHP, DiNP), eight perfluoroalkyl acids, and organochlorines (PCB-153 and p,p´‑DDE) were quantifiable in 72‒100% of maternal serum samples. We assessed associations between exposures and term birth weight, adjusting for co-exposures and covariates, including prepregnancy body mass index. To identify independent associations, we applied the elastic net penalty to linear regression models. Results: Two phthalate metabolites (MEHHP, MOiNP), perfluorooctanoic acid (PFOA), and p,p´-DDE were most consistently predictive of term birth weight based on elastic net penalty regression. In an adjusted, unpenalized regression model of the four exposures, 2-SD increases in natural log–transformed MEHHP, PFOA, and p,p´-DDE were associated with lower birth weight: –87 g (95% CI: –137, –340 per 1.70 ng/mL), –43 g (95% CI: –108, 23 per 1.18 ng/mL), and –135 g (95% CI: –192, –78 per 1.82 ng/g lipid), respectively; and MOiNP was associated with higher birth weight (46 g; 95% CI: –5, 97 per 2.22 ng/mL). Conclusions: This study suggests that several of the environmental contaminants, belonging to three chemical classes, may be independently associated with impaired fetal growth. These results warrant follow-up in other cohorts. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Environmental Health Perspectives 124 3 365 372 |
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Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Lenters, Virissa Portengen, Lützen Rignell-Hydbom, Anna Jönsson, Bo A G Lindh, Christian H. Piersma, Aldert H. Toft, Gunnar Bonde, Jens Peter Heederik, Dick Rylander, Lars Vermeulen, Roel Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression |
topic_facet |
Environmental Health and Occupational Health |
description |
Background: Some legacy and emerging environmental contaminants are suspected risk factors for intrauterine growth restriction. However, the evidence is equivocal, in part due to difficulties in disentangling the effects of mixtures. Objectives: We assessed associations between multiple correlated biomarkers of environmental exposure and birth weight. Methods: We evaluated a cohort of 1,250 term (≥ 37 weeks gestation) singleton infants, born to 513 mothers from Greenland, 180 from Poland, and 557 from Ukraine, who were recruited during antenatal care visits in 2002‒2004. Secondary metabolites of diethylhexyl and diisononyl phthalates (DEHP, DiNP), eight perfluoroalkyl acids, and organochlorines (PCB-153 and p,p´‑DDE) were quantifiable in 72‒100% of maternal serum samples. We assessed associations between exposures and term birth weight, adjusting for co-exposures and covariates, including prepregnancy body mass index. To identify independent associations, we applied the elastic net penalty to linear regression models. Results: Two phthalate metabolites (MEHHP, MOiNP), perfluorooctanoic acid (PFOA), and p,p´-DDE were most consistently predictive of term birth weight based on elastic net penalty regression. In an adjusted, unpenalized regression model of the four exposures, 2-SD increases in natural log–transformed MEHHP, PFOA, and p,p´-DDE were associated with lower birth weight: –87 g (95% CI: –137, –340 per 1.70 ng/mL), –43 g (95% CI: –108, 23 per 1.18 ng/mL), and –135 g (95% CI: –192, –78 per 1.82 ng/g lipid), respectively; and MOiNP was associated with higher birth weight (46 g; 95% CI: –5, 97 per 2.22 ng/mL). Conclusions: This study suggests that several of the environmental contaminants, belonging to three chemical classes, may be independently associated with impaired fetal growth. These results warrant follow-up in other cohorts. |
format |
Article in Journal/Newspaper |
author |
Lenters, Virissa Portengen, Lützen Rignell-Hydbom, Anna Jönsson, Bo A G Lindh, Christian H. Piersma, Aldert H. Toft, Gunnar Bonde, Jens Peter Heederik, Dick Rylander, Lars Vermeulen, Roel |
author_facet |
Lenters, Virissa Portengen, Lützen Rignell-Hydbom, Anna Jönsson, Bo A G Lindh, Christian H. Piersma, Aldert H. Toft, Gunnar Bonde, Jens Peter Heederik, Dick Rylander, Lars Vermeulen, Roel |
author_sort |
Lenters, Virissa |
title |
Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression |
title_short |
Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression |
title_full |
Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression |
title_fullStr |
Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression |
title_full_unstemmed |
Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : Multi-pollutant models based on elastic net regression |
title_sort |
prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts : multi-pollutant models based on elastic net regression |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2016 |
url |
https://lup.lub.lu.se/record/d081002e-5e4d-4b41-8878-479595208e17 https://doi.org/10.1289/ehp.1408933 |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Environmental Health Perspectives; 124(3), pp 365-372 (2016) ISSN: 0091-6765 |
op_relation |
https://lup.lub.lu.se/record/d081002e-5e4d-4b41-8878-479595208e17 http://dx.doi.org/10.1289/ehp.1408933 scopus:84959308178 wos:000371442500024 pmid:26115335 |
op_doi |
https://doi.org/10.1289/ehp.1408933 |
container_title |
Environmental Health Perspectives |
container_volume |
124 |
container_issue |
3 |
container_start_page |
365 |
op_container_end_page |
372 |
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1799481027587997696 |