Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations
Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p...
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2010
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ftulundlup:oai:lup.lub.lu.se:be926d03-253c-4c66-a2a6-4b1a3344b96d 2023-05-15T16:28:15+02:00 Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations Toft, Gunnar Thulstrup, Ane M. Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Zvezday, Valentyna Bonde, Jens P. 2010 https://lup.lub.lu.se/record/1632235 https://doi.org/10.1186/1476-069X-9-22 eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/1632235 http://dx.doi.org/10.1186/1476-069X-9-22 wos:000278269300001 scopus:77951957462 pmid:20459724 Environmental Health; 9 (2010) ISSN: 1476-069X Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2010 ftulundlup https://doi.org/10.1186/1476-069X-9-22 2023-02-01T23:32:39Z Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p, p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p, p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Greenland Environmental Health 9 1 |
institution |
Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Toft, Gunnar Thulstrup, Ane M. Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Zvezday, Valentyna Bonde, Jens P. Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations |
topic_facet |
Environmental Health and Occupational Health |
description |
Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p, p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p, p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions. |
format |
Article in Journal/Newspaper |
author |
Toft, Gunnar Thulstrup, Ane M. Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Zvezday, Valentyna Bonde, Jens P. |
author_facet |
Toft, Gunnar Thulstrup, Ane M. Jönsson, Bo A Pedersen, Henning S. Ludwicki, Jan K. Zvezday, Valentyna Bonde, Jens P. |
author_sort |
Toft, Gunnar |
title |
Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations |
title_short |
Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations |
title_full |
Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations |
title_fullStr |
Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations |
title_full_unstemmed |
Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations |
title_sort |
fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (cb-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-dde) exposure: a cohort study in greenland and two european populations |
publisher |
BioMed Central (BMC) |
publishDate |
2010 |
url |
https://lup.lub.lu.se/record/1632235 https://doi.org/10.1186/1476-069X-9-22 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Environmental Health; 9 (2010) ISSN: 1476-069X |
op_relation |
https://lup.lub.lu.se/record/1632235 http://dx.doi.org/10.1186/1476-069X-9-22 wos:000278269300001 scopus:77951957462 pmid:20459724 |
op_doi |
https://doi.org/10.1186/1476-069X-9-22 |
container_title |
Environmental Health |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766017893029380096 |