Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden
Bank voles are known reservoirs for Puumala hantavirus and probably also for Ljungan virus (LV), a suggested candidate parechovirus in type 1 diabetes etiology and pathogenesis. The aim of this study was to determine whether wild bank voles had been exposed to LV and if exposure associated to autoan...
Published in: | Journal of Medical Virology |
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John Wiley & Sons Inc.
2017
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Online Access: | https://lup.lub.lu.se/record/b45ec325-bda4-4b6c-9310-5b8038018561 https://doi.org/10.1002/jmv.24597 |
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ftulundlup:oai:lup.lub.lu.se:b45ec325-bda4-4b6c-9310-5b8038018561 2024-02-11T10:07:11+01:00 Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden Warvsten, Anna Björnfors, Martin Arvidsson, Michael Vaziri-Sani, Fariba Jönsson, Ida Olsson, Gert E Ahlm, Clas Larsson, Helena Elding Lernmark, Åke Nilsson, Anna-Lena 2017-01 https://lup.lub.lu.se/record/b45ec325-bda4-4b6c-9310-5b8038018561 https://doi.org/10.1002/jmv.24597 eng eng John Wiley & Sons Inc. https://lup.lub.lu.se/record/b45ec325-bda4-4b6c-9310-5b8038018561 http://dx.doi.org/10.1002/jmv.24597 pmid:27283793 scopus:84978402688 wos:000387165200005 Journal of Medical Virology; 89(1), pp 24-31 (2017) ISSN: 1096-9071 Endocrinology and Diabetes Journal Article contributiontojournal/article info:eu-repo/semantics/article text 2017 ftulundlup https://doi.org/10.1002/jmv.24597 2024-01-17T23:29:21Z Bank voles are known reservoirs for Puumala hantavirus and probably also for Ljungan virus (LV), a suggested candidate parechovirus in type 1 diabetes etiology and pathogenesis. The aim of this study was to determine whether wild bank voles had been exposed to LV and if exposure associated to autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), or islet autoantigen-2 (IA-2A). Serum samples from bank voles (Myodes glareolus) captured in early summer or early winter of 1997 and 1998, respectively, were analyzed in radio binding assays for antibodies against Ljungan virus (LVA) and Puumala virus (PUUVA) as well as for IAA, GADA, and IA-2A. LVA was found in 25% (189/752), IAA in 2.5% (18/723), GADA in 2.6% (15/615), and IA-2A in 2.5% (11/461) of available bank vole samples. LVA correlated with both IAA (P = 0.007) and GADA (P < 0.001), but not with IA-2A (P = 0.999). There were no correlations with PUUVA, detected in 17% of the bank voles. Compared to LVA negative bank voles, LVA positive animals had higher levels of both IAA (P = 0.002) and GADA (P < 0.001), but not of IA-2A (P = 0.205). Levels of LVA as well as IAA and GADA were higher in samples from bank voles captured in early summer. In conclusion, LVA was detected in bank voles and correlated with both IAA and GADA but not with IA-2A. These observations suggest that exposure to LV may be associated with islet autoimmunity. It remains to be determined if islet autoantibody positive bank voles may develop diabetes in the wild. J. Med. Virol. 89:24-31, 2017. © 2016 Wiley Periodicals, Inc. Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Journal of Medical Virology 89 1 24 31 |
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Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Endocrinology and Diabetes Journal Article |
spellingShingle |
Endocrinology and Diabetes Journal Article Warvsten, Anna Björnfors, Martin Arvidsson, Michael Vaziri-Sani, Fariba Jönsson, Ida Olsson, Gert E Ahlm, Clas Larsson, Helena Elding Lernmark, Åke Nilsson, Anna-Lena Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden |
topic_facet |
Endocrinology and Diabetes Journal Article |
description |
Bank voles are known reservoirs for Puumala hantavirus and probably also for Ljungan virus (LV), a suggested candidate parechovirus in type 1 diabetes etiology and pathogenesis. The aim of this study was to determine whether wild bank voles had been exposed to LV and if exposure associated to autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), or islet autoantigen-2 (IA-2A). Serum samples from bank voles (Myodes glareolus) captured in early summer or early winter of 1997 and 1998, respectively, were analyzed in radio binding assays for antibodies against Ljungan virus (LVA) and Puumala virus (PUUVA) as well as for IAA, GADA, and IA-2A. LVA was found in 25% (189/752), IAA in 2.5% (18/723), GADA in 2.6% (15/615), and IA-2A in 2.5% (11/461) of available bank vole samples. LVA correlated with both IAA (P = 0.007) and GADA (P < 0.001), but not with IA-2A (P = 0.999). There were no correlations with PUUVA, detected in 17% of the bank voles. Compared to LVA negative bank voles, LVA positive animals had higher levels of both IAA (P = 0.002) and GADA (P < 0.001), but not of IA-2A (P = 0.205). Levels of LVA as well as IAA and GADA were higher in samples from bank voles captured in early summer. In conclusion, LVA was detected in bank voles and correlated with both IAA and GADA but not with IA-2A. These observations suggest that exposure to LV may be associated with islet autoimmunity. It remains to be determined if islet autoantibody positive bank voles may develop diabetes in the wild. J. Med. Virol. 89:24-31, 2017. © 2016 Wiley Periodicals, Inc. |
format |
Article in Journal/Newspaper |
author |
Warvsten, Anna Björnfors, Martin Arvidsson, Michael Vaziri-Sani, Fariba Jönsson, Ida Olsson, Gert E Ahlm, Clas Larsson, Helena Elding Lernmark, Åke Nilsson, Anna-Lena |
author_facet |
Warvsten, Anna Björnfors, Martin Arvidsson, Michael Vaziri-Sani, Fariba Jönsson, Ida Olsson, Gert E Ahlm, Clas Larsson, Helena Elding Lernmark, Åke Nilsson, Anna-Lena |
author_sort |
Warvsten, Anna |
title |
Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden |
title_short |
Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden |
title_full |
Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden |
title_fullStr |
Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden |
title_full_unstemmed |
Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden |
title_sort |
islet autoantibodies present in association with ljungan virus infection in bank voles (myodes glareolus) in northern sweden |
publisher |
John Wiley & Sons Inc. |
publishDate |
2017 |
url |
https://lup.lub.lu.se/record/b45ec325-bda4-4b6c-9310-5b8038018561 https://doi.org/10.1002/jmv.24597 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Medical Virology; 89(1), pp 24-31 (2017) ISSN: 1096-9071 |
op_relation |
https://lup.lub.lu.se/record/b45ec325-bda4-4b6c-9310-5b8038018561 http://dx.doi.org/10.1002/jmv.24597 pmid:27283793 scopus:84978402688 wos:000387165200005 |
op_doi |
https://doi.org/10.1002/jmv.24597 |
container_title |
Journal of Medical Virology |
container_volume |
89 |
container_issue |
1 |
container_start_page |
24 |
op_container_end_page |
31 |
_version_ |
1790605345887879168 |