Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study
Introduction. An increased rate of cardiovascular disease (CVD) has been suggested in patients with systemic lupus erythematosus (SLE). The risk for myocardial infarction (MI), coronary artery disease and stroke has been reported as particularly prevalent in younger females compared with the referen...
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ftulundlup:oai:lup.lub.lu.se:b3c0a670-6f4b-44e8-8176-c95682ce205b 2023-05-15T17:44:35+02:00 Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study Bengtsson, Christine Ohman, M-L Nived, Ola Dahlqvist, S. Rantapaa 2012 https://lup.lub.lu.se/record/2515412 https://doi.org/10.1177/0961203311425524 eng eng SAGE Publications https://lup.lub.lu.se/record/2515412 http://dx.doi.org/10.1177/0961203311425524 wos:000301583400014 pmid:22065097 scopus:84858673576 Lupus; 21(4), pp 452-459 (2012) ISSN: 0961-2033 Rheumatology and Autoimmunity systemic lupus erythematosus predictors outcome research cardiovascular incidence epidemiology atherosclerosis contributiontojournal/article info:eu-repo/semantics/article text 2012 ftulundlup https://doi.org/10.1177/0961203311425524 2023-02-01T23:29:01Z Introduction. An increased rate of cardiovascular disease (CVD) has been suggested in patients with systemic lupus erythematosus (SLE). The risk for myocardial infarction (MI), coronary artery disease and stroke has been reported as particularly prevalent in younger females compared with the reference population. This study was performed to analyse the standard incidence ratio (SIR) of and predictors for cardiovascular events (CVEs) in patients with SLE from northern Sweden, with a fairly homogenous population. Methods. In 2000 all prevalent patients with SLE (>= 4 American College of Rheumatology [ACR] criteria; n=277) from the four northern-most counties of Sweden were assessed with clinical and laboratory analyses. Seven years follow-up data concerning MI and stroke were extracted from the national registers of hospitalization and death in Sweden. The incidence ratio among the patients was compared with that for the general population from the same catchment area using data from the same register and Statistics Sweden. To identify time to event and CVE predictors, two matched controls for each patient were used and disease related variables as CVD predictors. Results. The SIR for a CVE was 1.27 (95% CI 0.82-1.87) and for females separately aged 40-49 years was 8.00 (95% CI 1.65-23.38). The overall SIR for MI was 2.31 (95% CI 1.34-3.7), for females overall was 1.75 (95% CI 0.84-3.22) and for females aged between 40 and 49 years was 8.7 (95% CI 1.1-31.4). The time to an event was significantly shorter among SLE patients (p<0.001) and was predicted by hypertension adjusted for smoking and disease. High SLEDAI and anti-cardiolipin IgG antibodies predicted an event in Cox proportional hazards regression models adjusted for age and previous MI. Diabetes, smoking ever and sex did not affect the prediction models. Conclusion. The risk of a CVE, or MI, was eight-or nine-fold greater among middle-aged female SLE patients. Time to event was significantly shorter and CVE was associated with SLE-related factors ... Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Lupus 21 4 452 459 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Rheumatology and Autoimmunity systemic lupus erythematosus predictors outcome research cardiovascular incidence epidemiology atherosclerosis |
spellingShingle |
Rheumatology and Autoimmunity systemic lupus erythematosus predictors outcome research cardiovascular incidence epidemiology atherosclerosis Bengtsson, Christine Ohman, M-L Nived, Ola Dahlqvist, S. Rantapaa Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study |
topic_facet |
Rheumatology and Autoimmunity systemic lupus erythematosus predictors outcome research cardiovascular incidence epidemiology atherosclerosis |
description |
Introduction. An increased rate of cardiovascular disease (CVD) has been suggested in patients with systemic lupus erythematosus (SLE). The risk for myocardial infarction (MI), coronary artery disease and stroke has been reported as particularly prevalent in younger females compared with the reference population. This study was performed to analyse the standard incidence ratio (SIR) of and predictors for cardiovascular events (CVEs) in patients with SLE from northern Sweden, with a fairly homogenous population. Methods. In 2000 all prevalent patients with SLE (>= 4 American College of Rheumatology [ACR] criteria; n=277) from the four northern-most counties of Sweden were assessed with clinical and laboratory analyses. Seven years follow-up data concerning MI and stroke were extracted from the national registers of hospitalization and death in Sweden. The incidence ratio among the patients was compared with that for the general population from the same catchment area using data from the same register and Statistics Sweden. To identify time to event and CVE predictors, two matched controls for each patient were used and disease related variables as CVD predictors. Results. The SIR for a CVE was 1.27 (95% CI 0.82-1.87) and for females separately aged 40-49 years was 8.00 (95% CI 1.65-23.38). The overall SIR for MI was 2.31 (95% CI 1.34-3.7), for females overall was 1.75 (95% CI 0.84-3.22) and for females aged between 40 and 49 years was 8.7 (95% CI 1.1-31.4). The time to an event was significantly shorter among SLE patients (p<0.001) and was predicted by hypertension adjusted for smoking and disease. High SLEDAI and anti-cardiolipin IgG antibodies predicted an event in Cox proportional hazards regression models adjusted for age and previous MI. Diabetes, smoking ever and sex did not affect the prediction models. Conclusion. The risk of a CVE, or MI, was eight-or nine-fold greater among middle-aged female SLE patients. Time to event was significantly shorter and CVE was associated with SLE-related factors ... |
format |
Article in Journal/Newspaper |
author |
Bengtsson, Christine Ohman, M-L Nived, Ola Dahlqvist, S. Rantapaa |
author_facet |
Bengtsson, Christine Ohman, M-L Nived, Ola Dahlqvist, S. Rantapaa |
author_sort |
Bengtsson, Christine |
title |
Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study |
title_short |
Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study |
title_full |
Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study |
title_fullStr |
Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study |
title_full_unstemmed |
Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study |
title_sort |
cardiovascular event in systemic lupus erythematosus in northern sweden: incidence and predictors in a 7-year follow-up study |
publisher |
SAGE Publications |
publishDate |
2012 |
url |
https://lup.lub.lu.se/record/2515412 https://doi.org/10.1177/0961203311425524 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Lupus; 21(4), pp 452-459 (2012) ISSN: 0961-2033 |
op_relation |
https://lup.lub.lu.se/record/2515412 http://dx.doi.org/10.1177/0961203311425524 wos:000301583400014 pmid:22065097 scopus:84858673576 |
op_doi |
https://doi.org/10.1177/0961203311425524 |
container_title |
Lupus |
container_volume |
21 |
container_issue |
4 |
container_start_page |
452 |
op_container_end_page |
459 |
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1766146828502302720 |