Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study
Background: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative str...
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Language: | English |
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BioMed Central (BMC)
2011
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Online Access: | https://lup.lub.lu.se/record/1985520 https://doi.org/10.1186/1476-069X-10-33 https://portal.research.lu.se/files/3957108/2172494.pdf |
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ftulundlup:oai:lup.lub.lu.se:b2f4b01b-6576-4406-afa9-0659f4c32e6f 2023-05-15T17:45:05+02:00 Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study Engström, Karin Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Goran Jansson, Jan-Hakan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg Palmgren, Karin 2011 application/pdf https://lup.lub.lu.se/record/1985520 https://doi.org/10.1186/1476-069X-10-33 https://portal.research.lu.se/files/3957108/2172494.pdf eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/1985520 http://dx.doi.org/10.1186/1476-069X-10-33 https://portal.research.lu.se/files/3957108/2172494.pdf wos:000291161800001 scopus:79955123363 pmid:21504558 info:eu-repo/semantics/openAccess Environmental Health; 10 (2011) ISSN: 1476-069X Environmental Health and Occupational Health Methylmercury myocardial infarction polymorphisms glutathione n-3 polyunsaturated long chain fatty acids contributiontojournal/article info:eu-repo/semantics/article text 2011 ftulundlup https://doi.org/10.1186/1476-069X-10-33 2023-02-01T23:26:40Z Background: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glutathione is also an antioxidant. Individuals with certain polymorphisms in glutathione-related genes may tolerate higher exposures to methylmercury, due to faster metabolism and elimination and/or better glutathione-associated antioxidative capacity. They would thus benefit more from the protective agents in fish, such as eicosapentaenoic+docosahexaenoic acid and selenium. The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction. Methods: Polymorphisms in glutathione-synthesizing (glutamyl-cysteine ligase catalytic subunit, GCLC and glutamyl-cysteine ligase modifier subunit, GCLM) or glutathione-conjugating (glutathione S-transferase P, GSTP1) genes were genotyped in 1027 individuals from northern Sweden (458 cases of first-ever myocardial infarction and 569 matched controls). The impact of these polymorphisms on the association between erythrocyte-mercury (proxy for methylmercury) and risk of myocardial infarction, as well as between plasma eicosapentaenoic+docosahexaenoic acid and risk of myocardial infarction, was evaluated by conditional logistic regression. The effect of erythrocyte-selenium on risk of myocardial infarction was also taken into consideration. Results: There were no strong genetic modifying effects on the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction risk. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, ... Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Environmental Health 10 1 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Methylmercury myocardial infarction polymorphisms glutathione n-3 polyunsaturated long chain fatty acids |
spellingShingle |
Environmental Health and Occupational Health Methylmercury myocardial infarction polymorphisms glutathione n-3 polyunsaturated long chain fatty acids Engström, Karin Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Goran Jansson, Jan-Hakan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg Palmgren, Karin Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
topic_facet |
Environmental Health and Occupational Health Methylmercury myocardial infarction polymorphisms glutathione n-3 polyunsaturated long chain fatty acids |
description |
Background: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glutathione is also an antioxidant. Individuals with certain polymorphisms in glutathione-related genes may tolerate higher exposures to methylmercury, due to faster metabolism and elimination and/or better glutathione-associated antioxidative capacity. They would thus benefit more from the protective agents in fish, such as eicosapentaenoic+docosahexaenoic acid and selenium. The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction. Methods: Polymorphisms in glutathione-synthesizing (glutamyl-cysteine ligase catalytic subunit, GCLC and glutamyl-cysteine ligase modifier subunit, GCLM) or glutathione-conjugating (glutathione S-transferase P, GSTP1) genes were genotyped in 1027 individuals from northern Sweden (458 cases of first-ever myocardial infarction and 569 matched controls). The impact of these polymorphisms on the association between erythrocyte-mercury (proxy for methylmercury) and risk of myocardial infarction, as well as between plasma eicosapentaenoic+docosahexaenoic acid and risk of myocardial infarction, was evaluated by conditional logistic regression. The effect of erythrocyte-selenium on risk of myocardial infarction was also taken into consideration. Results: There were no strong genetic modifying effects on the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction risk. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, ... |
format |
Article in Journal/Newspaper |
author |
Engström, Karin Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Goran Jansson, Jan-Hakan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg Palmgren, Karin |
author_facet |
Engström, Karin Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Goran Jansson, Jan-Hakan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg Palmgren, Karin |
author_sort |
Engström, Karin |
title |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_short |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_full |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_fullStr |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_full_unstemmed |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
title_sort |
evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study |
publisher |
BioMed Central (BMC) |
publishDate |
2011 |
url |
https://lup.lub.lu.se/record/1985520 https://doi.org/10.1186/1476-069X-10-33 https://portal.research.lu.se/files/3957108/2172494.pdf |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Environmental Health; 10 (2011) ISSN: 1476-069X |
op_relation |
https://lup.lub.lu.se/record/1985520 http://dx.doi.org/10.1186/1476-069X-10-33 https://portal.research.lu.se/files/3957108/2172494.pdf wos:000291161800001 scopus:79955123363 pmid:21504558 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/1476-069X-10-33 |
container_title |
Environmental Health |
container_volume |
10 |
container_issue |
1 |
_version_ |
1766147837344612352 |