Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort
Background: Exposures to per- and polyfluoroalkyl substances (PFASs) may affect metabolic outcomes, including lipid concentrations in the blood. However, few studies have evaluated potential associations between PFASs and lipids longitudinally. Objectives: We estimated associations between PFAS and...
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ftulundlup:oai:lup.lub.lu.se:ae3865b3-771d-4925-96fe-d1b9a2930db3 2024-05-19T07:40:03+00:00 Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort Blomberg, Annelise J. Shih, Yu Hsuan Messerlian, Carmen Jørgensen, Louise Helskov Weihe, Pál Grandjean, Philippe 2021 https://lup.lub.lu.se/record/ae3865b3-771d-4925-96fe-d1b9a2930db3 https://doi.org/10.1016/j.envres.2021.111400 eng eng Elsevier https://lup.lub.lu.se/record/ae3865b3-771d-4925-96fe-d1b9a2930db3 http://dx.doi.org/10.1016/j.envres.2021.111400 scopus:85108183213 pmid:34081971 Environmental Research; 200, no 111400 (2021) ISSN: 0013-9351 Cardiac and Cardiovascular Systems Cardiometabolic Childhood Lipids Per- and polyfluoroalkyl substances PFAS contributiontojournal/article info:eu-repo/semantics/article text 2021 ftulundlup https://doi.org/10.1016/j.envres.2021.111400 2024-04-23T23:51:31Z Background: Exposures to per- and polyfluoroalkyl substances (PFASs) may affect metabolic outcomes, including lipid concentrations in the blood. However, few studies have evaluated potential associations between PFASs and lipids longitudinally. Objectives: We estimated associations between PFAS and lipid concentrations at birth and at several points in childhood. Methods: We measured concentrations of five major PFASs in cord serum and in serum collected at 18 months, five years and nine years in 490 children from a prospective cohort in the Faroe Islands. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations were measured at birth, 18 months and nine years. We estimated associations between PFAS and lipid concentrations and evaluated possible effect modification by sex. We also tested whether PFAS associations with age-nine lipids varied by exposure period. Results: Serum PFAS concentrations at ages five and nine were positively associated with lipid concentrations at age nine. Cross-sectional associations between PFASs and lipids at age nine were the strongest, with increases in serum concentrations of perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA) and perfluorooctanesulfonic acid (PFOS) associated with increases in TC, HDL-C and LDL-C. We found statistically significant differences in estimated PFAS effects by sex, where girls had stronger positive associations between PFASs and TC and LDL-C and boys had stronger positive associations with HDL-C. In repeated measure models, exposure period was a significant modifier of PFAS effects. Conclusions: Our findings suggest that childhood PFAS exposures may be associated with elevated serum lipid concentrations. This is a public health concern, as a detrimental lipid profile in childhood is a risk factor for later development of hyperlipidemia and cardiovascular disease. Article in Journal/Newspaper Faroe Islands Lund University Publications (LUP) Environmental Research 200 111400 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cardiac and Cardiovascular Systems Cardiometabolic Childhood Lipids Per- and polyfluoroalkyl substances PFAS |
spellingShingle |
Cardiac and Cardiovascular Systems Cardiometabolic Childhood Lipids Per- and polyfluoroalkyl substances PFAS Blomberg, Annelise J. Shih, Yu Hsuan Messerlian, Carmen Jørgensen, Louise Helskov Weihe, Pál Grandjean, Philippe Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
topic_facet |
Cardiac and Cardiovascular Systems Cardiometabolic Childhood Lipids Per- and polyfluoroalkyl substances PFAS |
description |
Background: Exposures to per- and polyfluoroalkyl substances (PFASs) may affect metabolic outcomes, including lipid concentrations in the blood. However, few studies have evaluated potential associations between PFASs and lipids longitudinally. Objectives: We estimated associations between PFAS and lipid concentrations at birth and at several points in childhood. Methods: We measured concentrations of five major PFASs in cord serum and in serum collected at 18 months, five years and nine years in 490 children from a prospective cohort in the Faroe Islands. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations were measured at birth, 18 months and nine years. We estimated associations between PFAS and lipid concentrations and evaluated possible effect modification by sex. We also tested whether PFAS associations with age-nine lipids varied by exposure period. Results: Serum PFAS concentrations at ages five and nine were positively associated with lipid concentrations at age nine. Cross-sectional associations between PFASs and lipids at age nine were the strongest, with increases in serum concentrations of perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA) and perfluorooctanesulfonic acid (PFOS) associated with increases in TC, HDL-C and LDL-C. We found statistically significant differences in estimated PFAS effects by sex, where girls had stronger positive associations between PFASs and TC and LDL-C and boys had stronger positive associations with HDL-C. In repeated measure models, exposure period was a significant modifier of PFAS effects. Conclusions: Our findings suggest that childhood PFAS exposures may be associated with elevated serum lipid concentrations. This is a public health concern, as a detrimental lipid profile in childhood is a risk factor for later development of hyperlipidemia and cardiovascular disease. |
format |
Article in Journal/Newspaper |
author |
Blomberg, Annelise J. Shih, Yu Hsuan Messerlian, Carmen Jørgensen, Louise Helskov Weihe, Pál Grandjean, Philippe |
author_facet |
Blomberg, Annelise J. Shih, Yu Hsuan Messerlian, Carmen Jørgensen, Louise Helskov Weihe, Pál Grandjean, Philippe |
author_sort |
Blomberg, Annelise J. |
title |
Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
title_short |
Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
title_full |
Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
title_fullStr |
Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
title_full_unstemmed |
Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
title_sort |
early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://lup.lub.lu.se/record/ae3865b3-771d-4925-96fe-d1b9a2930db3 https://doi.org/10.1016/j.envres.2021.111400 |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Environmental Research; 200, no 111400 (2021) ISSN: 0013-9351 |
op_relation |
https://lup.lub.lu.se/record/ae3865b3-771d-4925-96fe-d1b9a2930db3 http://dx.doi.org/10.1016/j.envres.2021.111400 scopus:85108183213 pmid:34081971 |
op_doi |
https://doi.org/10.1016/j.envres.2021.111400 |
container_title |
Environmental Research |
container_volume |
200 |
container_start_page |
111400 |
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1799479631152152576 |